The effects of rearing condition on methamphetamine self-administration and cue-induced drug seeking

Lü, Xiuyi; Zhao, Chun; Zhang, Li; Ma, Baomiao; Lou, Zhongze; Sun, Yan; Chen, Junfeng; Wu, Wei; Beveridge, Thomas J.R.; Zhou, Wenhua; Liu, Yu

doi:10.1016/j.drugalcdep.2012.01.022

Cited by 17 publications

(13 citation statements)

References 42 publications

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“…These findings contrast with previous work showing reduced self-administration of methylphenidate [6], cocaine [4], and amphetamine [7] in EC rats compared to IC rats, especially at low unit doses. The current results also contrast with findings from a previous report by Lü et al [12] showing that, following termination of the differential housing conditions, EC rats self-administer less METH than IC rats during acquisition. However, in addition to the difference in housing conditions maintained during testing, Lü et al [12] used a training dose of 0.03 mg/kg/infusion, whereas the current experiment used a training dose of 0.1 mg/kg/infusion.…”

Section: Discussioncontrasting

confidence: 99%

“…The current results also contrast with findings from a previous report by Lü et al [12] showing that, following termination of the differential housing conditions, EC rats self-administer less METH than IC rats during acquisition. However, in addition to the difference in housing conditions maintained during testing, Lü et al [12] used a training dose of 0.03 mg/kg/infusion, whereas the current experiment used a training dose of 0.1 mg/kg/infusion. The higher training dose used here was selected specifically to minimize the potential for differential rates of acquisition prior to dose response determination.…”

Section: Discussioncontrasting

confidence: 99%

“…The purpose of the current study was to extend the results provided by Lü et al [12], except rats were tested during the period of differential rearing, rather than after differential rearing was terminated. METH CPP was evaluated in EC and IC rats using doses shown previously to be rewarding in our laboratory [10, 22, 23].…”

Section: Introductionmentioning

confidence: 92%

“…Using CPP, an effect of enrichment on METH reward has not been observed in either mice or rats [10, 11]. However, a recent study by Lü et al [12] demonstrated differential sensitivity to METH in a nose-poke self-administration paradigm, with EC rats self-administering less METH at a unit dose of 0.03 mg/kg compared to IC rats; no differences were evident at higher unit doses. Cue-elicited reinstatement of METH seeking also was decreased in EC rats following a period of response extinction.…”

Section: Introductionmentioning

confidence: 99%

“…METH CPP was evaluated in EC and IC rats using doses shown previously to be rewarding in our laboratory [10, 22, 23]. Additionally, METH self-administration was evaluated across various unit doses of METH (0.001–0.5 mg/kg/infusion) after first establishing reliable acquisition in both EC and IC rats using a high training dose of METH (0.1 mg/kg/infusion), which contrasts with the low dose used during acquisition training by Lü et al [12]. Following a period of extinction, EC and IC rats were subsequently evaluated for cue-induced reinstatement of METH seeking.…”

Section: Introductionmentioning

confidence: 99%

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Environmental enrichment reduces methamphetamine cue-induced reinstatement but does not alter methamphetamine reward or VMAT2 function

Hofford

Darna

Wilmouth

et al. 2014

Behavioural Brain Research

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Environmental factors influence a variety of health-related outcomes. In general, being raised in an environment possessing social, sensory, and motor enrichment reduces the rewarding effects of various drugs, thus protecting against abuse vulnerability. However, in the case of methamphetamine (METH), which acts at the vesicular monoamine transporter 2 (VMAT2) to enhance dopamine release from the cytosol, previous evidence suggests that METH reward may not be altered by environmental enrichment. This study examined the influence of an enriched environment on measures of METH reward, METH seeking, and VMAT2 function. Rats were raised from weaning to adulthood in either an enriched environment (presence of social cohorts and novel objects) or an isolated environment (no cohorts or novel objects). Rats in these two conditions were subsequently tested for their acquisition of conditioned place preference (CPP), METH self-administration, maintenance of self-administration at various unit doses of METH (0.001–0.5 mg/kg/infusion), and cue-induced reinstatement. VMAT2 function in striatum from these two groups also was assessed. No significant environment effects were found in CPP or METH self-administration, which paralleled a lack of effect in VMAT2 function between groups. However, cue-induced reinstatement was reduced by environmental enrichment. Together, these results suggest that environmental enrichment does not alter VMAT2 function involved in METH reward. However, the enrichment-induced decrease in cue-induced reinstatement indicates that enrichment may have a beneficial effect against relapse following a period of extinction via a neural mechanism other than striatal VMAT2 function.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Environmental enrichment reduces methamphetamine cue-induced reinstatement but does not alter methamphetamine reward or VMAT2 function

Hofford

Darna

Wilmouth

et al. 2014

Behavioural Brain Research

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The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Baker

Magnuson

Dahly

et al. 2018

Developmental Psychobiology

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Methamphetamine alters behavior and the stress response system. Relatively little research has examined the effects of methamphetamine in adolescents and compared these effects to those in adults. Housing in enriched environments has been explored as one way to protect against the effects of methamphetamine, but the findings are conflicting and no study has examined how enriched environment may alter the behavioral and corticosterone responses to methamphetamine in adolescent and adult rodents. We examined the long-term effects of methamphetamine exposure on anxiety, social behavior, behavioral despair, and corticosterone levels in adolescent and adult mice housed in enriched or isolated environments. Enriched environment did not alter the behavioral or corticosterone response to methamphetamine. Methamphetamine exposure decreased anxiety and increased behavioral despair in adult mice, but methamphetamine did not alter behavior in adolescent mice. There was no effect of methamphetamine on social behavior or corticosterone levels. Our findings demonstrate that the specific environmental enrichment paradigm used in this study was not sufficient to mitigate the behavioral effects of methamphetamine and that adolescent mice are relatively resistant to the effects of methamphetamine compared to adult mice.

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Environmental Enrichment and the Effects on Drug Abuse Vulnerability: The Last Ten Years

Stairs

Hanson

Kellerman

2021

Methods for Preclinical Research in Addiction

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The effects of rearing condition on methamphetamine self-administration and cue-induced drug seeking

Cited by 17 publications

References 42 publications

Environmental enrichment reduces methamphetamine cue-induced reinstatement but does not alter methamphetamine reward or VMAT2 function

Environmental enrichment reduces methamphetamine cue-induced reinstatement but does not alter methamphetamine reward or VMAT2 function

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Environmental Enrichment and the Effects on Drug Abuse Vulnerability: The Last Ten Years

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