The Effects of Raw Material, Irradiation Dose, and Irradiation Source on Crosslinking of UHMWPE

Greer, KW; King, RS; Chan, FW

doi:10.1520/jai11217

Cited by 12 publications

(12 citation statements)

References 5 publications

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“…This study also confirmed previous studies [24,38,39] that showed that mechanical properties are affected by radiation crosslinking, particularly ultimate tensile strength (UTS), elongation at break, and impact strength. It stands to reason that the mechanically strongest material would be the ideal choice for use in orthopaedic implants.…”

Section: Discussionsupporting

confidence: 91%

“…The differences in these metrics between the 7.5-XLPE and 10-XLPE materials was not significant at the levels evaluated in this study. Within the dose range examined, these values were similar to those reported by Greer and co-authors [24] as demonstrated in Figures 2 and 3. [24] are also plotted for comparison.…”

Section: Molecular Network Parameterssupporting

confidence: 89%

“…Within the dose range examined, these values were similar to those reported by Greer and co-authors [24] as demonstrated in Figures 2 and 3. [24] are also plotted for comparison. The error bars represent the standard deviations.…”

Section: Molecular Network Parameterssupporting

confidence: 89%

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Design of an Advanced Bearing System for Total Knee Arthroplasty

2015

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Abstract:The objective of this study was to develop an advanced-bearing couple for TKA that optimizes the balance between wear resistance and mechanical properties. The mechanical and structural properties of virgin and highly crosslinked, re-melted UHMWPE were evaluated, and tibial inserts manufactured from these UHMWPE materials were tested against either oxidized zirconium (OxZr) or CoCr femoral components on a knee simulator. This study confirmed that the wear resistance of crosslinked UHMWPE improves with increasing radiation dose but is accompanied by a concomitant reduction in mechanical properties. Compared to CoCr, the ceramic surface of OxZr allows the use of a lower irradiation dose to achieve equivalent reductions in wear rates. As a result, a given wear rate can be achieved without sacrificing the mechanical properties to the same extent that is necessary with a CoCr femoral component. The advantage of ceramic counter bearing surfaces extends to both pristine and microabrasive conditions.

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Section: Discussionsupporting

confidence: 91%

Section: Molecular Network Parameterssupporting

confidence: 89%

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Design of an Advanced Bearing System for Total Knee Arthroplasty

2015

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“…We therefore deemed that the substrate was CLPE, although it was shielded by the MPC layer. In a previous study using gamma irradiation, 28 the lower-molecular-weight cross-linked GUR1020 materials had higher mechanical properties (tensile and impact properties) for all doses compared to the higher-molecular-weight cross-linked GUR1050 materials. Nevertheless, the cross-linked GUR1020 materials exhibited the same wear rate as the cross-linked GUR1050 materials.…”

Section: Discussionmentioning

confidence: 70%

Enhanced wear resistance of modified cross‐linked polyethylene by grafting with poly(2‐methacryloyloxyethyl phosphorylcholine)

Kyomoto¹,

Moro

Konno

et al. 2007

J Biomedical Materials Res

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We developed a cross-linked polyethylene (CLPE) modified with a phospholipid polymer in order to address the serious problem of osteolysis caused by wear particles derived from the polyethylene components of artificial hip joints. Our goal of preventing aseptic loosening could be achieved by avoiding any formation of CLPE wear particles or suppressing the activation of cell systems by the wear particles. We investigated the surface and wear resistance properties of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer grafted onto the surface of CLPE (CLPE-g-MPC). The relative density of MPC polymer chains was determined by the P-O group index. Generally, polymerization times correspond to the number of polymer chains in radical polymerization. After 3.0 x 10(6) cycles in a hip joint simulator test, the steady wear rates of the untreated CLPE and CLPE-g-MPC cups with a low P-O group index were as high as 4 mg/10(6) cycles; those of the CLPE-g-MPC cups with high P-O group indexes, that is, 0.46 and 0.48, markedly decreased to -1.12 and 0.16 mg/10(6) cycles, respectively. Therefore, the grafting of an MPC polymer with high density would be essential in order to maintain the long-term wear resistance of CLPE-g-MPC as an orthopedic bearing material.

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“…Starting in the late 1990s, the polyethylene research community turned its full attention to understanding and standardizing radiation crosslinking, whether by gamma radiation or electron beam irradiation, when combined with annealing and remelting thermal treatments [12,53,54,68,81,84,95,97,103,134,146]. In parallel with the expansion of scientific inquiry, the scope and number of international standards related to medical-grade UHMWPE increased.…”

Section: History and Development Of Hxlpementioning

confidence: 99%

History and Systematic Review of Wear and Osteolysis Outcomes for First-generation Highly Crosslinked Polyethylene

Kurtz

Gawel

Patel

2011

Clinical Orthopaedics &Amp; Related Research

403

282

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Background Highly crosslinked polyethylene (HXLPE) was introduced to reduce wear and osteolysis in total joint arthroplasty. While many studies report wear and osteolysis associated with HXLPE, analytical techniques, clinical study design and followup, HXLPE formulation and implant design characteristics, and patient populations differ substantially among investigations, complicating a unified perspective. Questions/purposes Literature on first-generation HXLPE was summarized. We systematically reviewed the radiographic wear data and incidence of osteolysis for HXLPE in hip and knee arthroplasty. Methods PubMed identified 391 studies; 28 met inclusion criteria for a weighted-averages analysis of two-dimensional femoral head penetration rates. To determine the incidence of osteolysis, we estimated a pooled odds ratio using a random-effects model.Results Weighted-averages analyses of femoral head penetration rates in HXLPE liners and conventional UHMWPE liners resulted, respectively, in a mean twodimensional linear penetration rate of 0.042 mm/year based on 28 studies (n = 1503 hips) and 0.137 mm/year based on 18 studies (n = 695 hips). The pooled odds ratio for the risk of osteolysis in HXLPE versus conventional liners was 0.13 (95% confidence interval, 0.06-0.27) among studies with minimum 5-year followup. We identified two clinical studies of HXLPE in TKA, preventing systematic analysis of outcomes. Conclusions HXLPE liner studies consistently report lower femoral head penetration and an 87% lower risk of osteolysis. Reduction in femoral head penetration or osteolysis risk is not established for large-diameter ([ 32 mm) metallic femoral heads or ceramic femoral heads of any size. Few studies document the clinical performance of HXLPE in knees.

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The Effects of Raw Material, Irradiation Dose, and Irradiation Source on Crosslinking of UHMWPE

Cited by 12 publications

References 5 publications

Design of an Advanced Bearing System for Total Knee Arthroplasty

Design of an Advanced Bearing System for Total Knee Arthroplasty

Enhanced wear resistance of modified cross‐linked polyethylene by grafting with poly(2‐methacryloyloxyethyl phosphorylcholine)

History and Systematic Review of Wear and Osteolysis Outcomes for First-generation Highly Crosslinked Polyethylene

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