The effects of raloxifene hydrochloride on ocular hemodynamics and visual function

Siesky, Brent; Harris, Alon; Kheradiya, Nisha; Ehrlich, Rita; Klaas, C.; Kaplan, Boaris; Catoira, Yara; McCranor, L.; Rospigliosi, Carlos; Harris, Mira

doi:10.1007/s10792-008-9224-4

Cited by 5 publications

(2 citation statements)

References 26 publications

(49 reference statements)

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“… 172 Three months treatment with the selective estrogen-receptor modulator raloxifene had no effects on ocular blood flow in postmenopausal women. 173 It is, however, possible that raloxifene has an effect on ocular blood flow regulation in response to changes in OPP. Raloxifene lowers vascular tone via upregulation of the production of nitric oxide (NO) as well as through inhibition of L-type calcium channels in vascular smooth muscle cells.…”

Section: The Influence Of Sex Hormones On Ocular Blood Flowmentioning

confidence: 99%

Gender Differences in Ocular Blood Flow

Schmidl

Schmetterer

Garhöfer

et al. 2014

Current Eye Research

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Gender medicine has been a major focus of research in recent years. The present review focuses on gender differences in the epidemiology of the most frequent ocular diseases that have been found to be associated with impaired ocular blood flow, such as age-related macular degeneration, glaucoma and diabetic retinopathy. Data have accumulated indicating that hormones have an important role in these diseases, since there are major differences in the prevalence and incidence between men and pre- and post-menopausal women. Whether this is related to vascular factors is, however, not entirely clear. Interestingly, the current knowledge about differences in ocular vascular parameters between men and women is sparse. Although little data is available, estrogen, progesterone and testosterone are most likely important regulators of blood flow in the retina and choroid, because they are key regulators of vascular tone in other organs. Estrogen seems to play a protective role since it decreases vascular resistance in large ocular vessels. Some studies indicate that hormone therapy is beneficial for ocular vascular disease in post-menopausal women. This evidence is, however, not sufficient to give any recommendation. Generally, remarkably few data are available on the role of sex hormones on ocular blood flow regulation, a topic that requires more attention in the future.

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Section: The Influence Of Sex Hormones On Ocular Blood Flowmentioning

confidence: 99%

Gender Differences in Ocular Blood Flow

Schmidl

Schmetterer

Garhöfer

et al. 2014

Current Eye Research

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show abstract

“…Conversely, another study found no difference in retinal or retrobulbar blow flow measurements in comparing the effects of Raloxifene on postmenopausal women. 54 Retrobulbar blood vessel caliber analysis in several large studies failed to reveal any differences between males and females. [55][56] These findings suggest the importance of sex hormones as viable candidates to explain retrobulbar blood flow differences among men and women.…”

Section: Gendermentioning

confidence: 99%

Mathematical modeling and glaucoma: the need for an individualized approach to risk assessment

Vercellin

Harris

Cordell³

et al. 2016

MAIO

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Primary open-angle glaucoma is a chronic optic neuropathy characterized by retinal ganglion cell loss and subsequent visual field impairment. Elevated intraocular pressure remains the only treatable and modifiable risk factor and vascular impairment has been demonstrated in glaucomatous patients. New research has uncovered varying and often contradictory data suggesting more than just a casual correlation with ethnicity, diabetes, gender, obesity and age. Little is known about each variables’ contribution to the etiology of glaucoma and how their presence or absence with other risk factors potentiate or reduce an individual’s overall risk. The realization that glaucoma is more than a simple, binary disease necessitates a next-generation mathematical model with the capability to integrate individual patient characteristics and clinical risk factors to predict its formation and progression.

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Drug-induced ocular side effects

2015

Drug-Induced Ocular Side Effects

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The effects of raloxifene hydrochloride on ocular hemodynamics and visual function

Abstract: Raloxifene therapy at 60 mg/day had no clinically significant impact on BP, IOP or OBF in post-menopausal women.

Cited by 5 publications

References 26 publications

Gender Differences in Ocular Blood Flow

Gender Differences in Ocular Blood Flow

Mathematical modeling and glaucoma: the need for an individualized approach to risk assessment

Drug-induced ocular side effects

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