The effects of quercetin supplementation on cognitive functioning in a community sample: a randomized, placebo-controlled trial

Broman-Fulks, Joshua J.; Canu, Will H.; Trout, Krystal L.; Nieman, David C.

doi:10.1177/2045125312445894

Cited by 35 publications

(22 citation statements)

References 20 publications

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“…On the other hand, a contradictory study in a large community sample, with a 12-week supplementation of quercetin, provided evidence that quercetin may not have an ergogenic effect on neurocognitive functioning [ 250 ], consistent with a growing body of literature raising concerns about the generalization of findings from in vitro and animal quercetin research to human populations.…”

Section: Neuroprotective Potential Of Polyphenolsmentioning

confidence: 84%

Polyphenols Beyond Barriers: A Glimpse into the Brain

Figueira

Menezes

Macedo

et al. 2017

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BackgroundAgeing can be simply defined as the process of becoming older, which is genetically determined but also environmentally modulated. With the continuous increase of life expectancy, quality of life during ageing has become one of the biggest challenges of developed countries. The quest for a healthy ageing has led to the extensive study of plant polyphenols with the aim to prevent age-associated deterioration and diseases, including neurodegenerative diseases. The world of polyphenols has fascinated researchers over the past decades, and in vitro, cell-based, animal and human studies have attempted to unravel the mechanisms behind dietary polyphenols neuroprotection.MethodsIn this review, we compiled some of the extensive and ever-growing research in the field, highlighting some of the most recent trends in the area.ResultsThe main findings regarding polypolyphenols neuroprotective potential performed using in vitro, cellular and animal studies, as well as human trials are covered in this review. Concepts like bioavailability, polyphenols biotransformation, transport of dietary polyphenols across barriers, including the blood-brain barrier, are here explored.ConclusionThe diversity and holistic properties of polypolyphenol present them as an attractive alternative for the treatment of multifactorial diseases, where a multitude of cellular pathways are disrupted. The underlying mechanisms of polypolyphenols for nutrition or therapeutic applications must be further consolidated, however there is strong evidence of their beneficial impact on brain function during ageing. Nevertheless, only the tip of the iceberg of nutritional and pharmacological potential of dietary polyphenols is hitherto understood and further research needs to be done to fill the gaps in pursuing a healthy ageing.

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Section: Neuroprotective Potential Of Polyphenolsmentioning

confidence: 84%

Polyphenols Beyond Barriers: A Glimpse into the Brain

Figueira

Menezes

Macedo

et al. 2017

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show abstract

“…Moreover, mice administered with quercetin supplements showed increased learning and memory function in healthy mice when compared to untreated mice [62]. However, quercetin (500 mg/day) administration for 12 weeks failed to exhibit a significant effect on neurocognitive functioning in humans, raising concern the clinical translation of results from in vitro and in vivo animal studies [63]. Quercetin enhanced the spatial memory in aged and ethanol intoxicated mice through it antioxidant and scavenging properties [64].…”

Section: Discussionmentioning

confidence: 99%

Nootropic and Anti-Stress Effects of Allium Cepa Bulb and Quercetin in Male Mice

2019

ABBSR

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Allium cepa L (A.cepa; onion) is a traditional nutraceutical and medicinal plant that contains phenolics and flavonoids that have potential anti-inflammatory, anti-cholesterol, anticancer, and antioxidant properties. Quercetin is a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also has antioxidant, anti-inflammatory and antidepressant effects. The present study is aimed to investigate the anti-stress and nootropic effects of A.cepa bulb and quercetin in mice. Animals were divided into control and 2 test groups. Control mice were received drinking water while test groups were treated with suspension of grinded onion bulb in water (200 mg/kg; test group 1) and intraperitoneal injection of quercetin dissolved in ethanol (20mg/kg/ ml; test group 2) daily for 14 days. Behavioral activities of animals were monitored 14 days post administration of A.cepa and quercetin. Antidepressant effects were measured by forced swimming test (FST). Anxiolytic effects were monitored by using light dark activity (LDA) test and elevated plus maze (EPM) test and memory functions were assessed by morris water maze (MWM) test. Results showed that both A.cepa bulb and quercetin increased time spent in light box and open arm of LDA and EPM, exhibited anxiolytic effect than control group. A significant increase in immobility time was observed in FST in test groups than control suggesting antidepressant like effects. Moreover, nootropic effect were assessed by MWM showed significant increased in latency escape while observing short and long term memory for both test groups than control. It is suggested that both A.cepa and quercetin have anti-stress and nootropic effects.

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“…However, other clinical trials failed to report beneficial effects of quercetin on cognitive function (233). This discrepancy might be explained by block the IRE1α-XBP1 pathway (205,206) because of its implication in several cancer pathologies, including breast (62) and pancreatic (207) cancers.…”

Section: Potential Mediators Of Xbp1 Signaling In Neuronsmentioning

confidence: 90%

The Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s Disease

Cissé

Duplan

Checler

2016

Mol Med

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X-box binding protein 1 (XBP1) is a unique basic region leucine zipper transcription factor that was isolated two decades ago in a search for regulators of major histocompatibility complex class II gene expression. XBP1 is a very complex protein that regulates many physiological functions, including the immune system, inflammatory responses and lipid metabolism. Evidence over the past few years suggests that XBP1 also plays an important role in pathological settings, since its activity as a transcription factor has profound effects on the prognosis and progression of diseases such as cancer, neurodegeneration and diabetes. Here we provide an overview of recent advances in our understanding of this multifaceted molecule, particularly in regulating synaptic plasticity and memory function, and the implications in neurodegenerative diseases, with an emphasis on Alzheimer's disease.

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The effects of quercetin supplementation on cognitive functioning in a community sample: a randomized, placebo-controlled trial

Cited by 35 publications

References 20 publications

Polyphenols Beyond Barriers: A Glimpse into the Brain

Polyphenols Beyond Barriers: A Glimpse into the Brain

Nootropic and Anti-Stress Effects of Allium Cepa Bulb and Quercetin in Male Mice

The Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s Disease

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