The effects of pumpkin seed oil supplementation on arterial hemodynamics, stiffness and cardiac autonomic function in postmenopausal women

Wong, Alexei; Viola, Danielle; Bergen, Douglas; Caulfield, Eileen; Mehrabani, Javad; Figueroa, Arturo

doi:10.1016/j.ctcp.2019.08.003

Cited by 13 publications

(12 citation statements)

References 29 publications

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“…A placebo‐controlled RCT of parallel design evaluated the use of pumpkin seed oil by 23 postmenopausal women with elevated blood pressure for improving vascular function and reducing heart rate variability as well as blood pressure (Wong et al., 2019). Pumpkin seed oil was consumed in 1 g capsule, three times daily with meals.…”

Section: Health Benefits Of Specialty Seedsmentioning

confidence: 99%

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Alasalvar

Chang

Bolling

et al. 2021

Comp Rev Food Sci Food Safe

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Seeds play important roles in human nutrition and health since ancient time. The term “specialty” has recently been applied to seeds to describe high‐value and/or uncommon food products. Since then, numerous studies have been conducted to identify various classes of bioactive compounds, including polyphenols in specialty seeds. This review discusses nutrients, fat‐soluble bioactives, polyphenols/bioactives, antioxidant activity, bioavailability, health benefits, and safety/toxicology of commonly consumed eight specialty seeds, namely, black cumin, chia, hemp, flax, perilla, pumpkin, quinoa, and sesame. Scientific results from the existing literature published over the last decade have been compiled and discussed. These specialty seeds, having numerous fat‐soluble bioactives and polyphenols, together with their corresponding antioxidant activities, have increasingly been consumed. Hence, these specialty seeds can be considered as a valuable source of dietary supplements and functional foods due to their health‐promoting bioactive components, polyphenols, and corresponding antioxidant activities. The phytochemicals from these specialty seeds demonstrate bioavailability in humans with promising health benefits. Additional long‐term and well‐design human intervention trials are required to ascertain the health‐promoting properties of these specialty seeds.

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Section: Health Benefits Of Specialty Seedsmentioning

confidence: 99%

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Alasalvar

Chang

Bolling

et al. 2021

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

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“…In postmenopausal women, a study showed that supplementation with C. pepo seed oil increased high-density lipoprotein cholesterol concentrations, decreased the diastolic blood pressure, and improved the menopausal symptom scores (Gossell-Williams et al, 2011). A more recent study reported similar findings (Wong et al, 2019); thus, evidence suggests that Cucurbita provides health benefits for postmenopausal women. Likewise, a survey conducted by Vahlensieck et al (2015) found that patients with benign prostate hyperplasia treated with C. pepo seed (1,000 mg daily) exhibited a clinical improvement in their symptoms.…”

Section: Additional Confirmatory Clinical Trials Of the Beneficial Effects Of Cucurbitamentioning

confidence: 89%

Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders

Salehi

Quispe

Sharifi‐Rad

et al. 2021

Phytotherapy Research

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Oxidative stress is the imbalance between reactive oxygen species (ROS) production, and accumulation and the ability of a biological system to clear these reactive products. This imbalance leads to cell and tissue damage causing several disorders in human body, such as neurodegeneration, metabolic problems, cardiovascular diseases, and cancer. Cucurbitaceae family consists of about 100 genera and 1,000 species of plants including mostly tropical, annual or perennial, monoecious, and dioecious herbs. The plants from Cucurbita species are rich sources of phytochemicals and act as a rich source of antioxidants. The most important phytochemicals present in the cucurbits are cucurbitacins, saponins, carotenoids, phytosterols, and

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“…Whereas, an increase in HDL delivers significant CVD prevention (Barter, 2011). PSO has a balancing effect, not only on lipids, blood sugar, liver, prostate and bladder (Montesano et al, 2018;Patel, 2013) but it also augments arterial health and can reduce hypertension in postmenopausal women (Wong et al, 2019). This makes PSO a suitable supportive treatment option and worthy of further exploration.…”

Section: Introductionmentioning

confidence: 99%

Effect of pumpkin seed oil on cholesterol fractions and systolic/diastolic blood pressure

2020

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Pumpkin seed oil (PSO) is high in unsaturated fatty acids and plant sterols, which have numerous cardiovascular benefits. The study explores the hypothesis by investigating effects of consumption of 1000 mg of PSO on total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), systolic (SBP) and diastolic (DBP) blood pressure ((BP). PSO has high oxidative stability and contains favorable essential fatty acids profile along with sterols and tocopherols. One hundred and twenty-seven participants 39 to 63 years old, with varying degree of one or multiple medical conditions including dyslipidemia, hypertension, diabetes and obesity were randomly selected and assigned among case and control groups. Both groups were biochemically, anthropometrically and clinically assessed pre and post intervention. Group 1 (cases) (n=63) was administered 1000 mg of PSO along with recommendations for healthy diet and lifestyle whereas Group 2 (controls) (n=64), was only provided with dietary and lifestyle changes. Analysis of cases baseline and endpoint data revealed advantageous effect of intervention. Cases data showed a significant reduction in endpoint LDL and DBP values along with a likewise significant increase in HDL cholesterol. Experiment results revealed PSO possessed hypolipidemic and anti-hypertensive activity as it lowered DBP and LDL and increased HDL levels.

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The effects of pumpkin seed oil supplementation on arterial hemodynamics, stiffness and cardiac autonomic function in postmenopausal women

Cited by 13 publications

References 29 publications

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders

Effect of pumpkin seed oil on cholesterol fractions and systolic/diastolic blood pressure

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