The Effects of Pulmonary Rehabilitation in the National Emphysema Treatment Trial

Ries, Andrew L.; Make, Barry J.; Lee, Shing M.; Krasna, Mark J.; Bartels, Matthew N.; Crouch, R. H.; Fishman, Alfred P.

doi:10.1378/chest.128.6.3799

Cited by 175 publications

(92 citation statements)

References 16 publications

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“…Data from other centers showed a mean improvement in 6MWD of 70-190 feet [5,14,16,17]. Mean improvement in 6MWD among patients in our study was greater, at 263.8 feet.…”

Section: Discussionsupporting

confidence: 42%

“…The reason for this greater improvement in 6MWD compared to that demonstrated by other studies is not clear. A possible explanation is that our patients had never undergone PR, and we know from the National Emphysema Treatment Trial that benefits of PR are significantly greater in patients without prior rehabilitation experience [17]. Another possible explanation is the open floor plan of our center.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Pulmonary Rehabilitation: A Retrospective Study in Eastern North Carolina

Chalise

Shaheen

Rizwan

et al. 2016

North Carolina Medical Journal

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“…Data from other centers showed a mean improvement in 6MWD of 70-190 feet [5,14,16,17]. Mean improvement in 6MWD among patients in our study was greater, at 263.8 feet.…”

Section: Discussionsupporting

confidence: 42%

Section: Discussionmentioning

confidence: 98%

Pulmonary Rehabilitation: A Retrospective Study in Eastern North Carolina

Chalise

Shaheen

Rizwan

et al. 2016

North Carolina Medical Journal

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“…Maximal exercise capacity was assessed by Wmax and VO 2 peak using an incremental symptom-limited cycle ergometer test and compared with normal values [18]. A change exceeding 10 W was considered as MCID [25]. QF was assessed using an isometric handheld dynamometer (Microfet; Biometrics, Almere, the Netherlands) attached to a knee pendicular bank.…”

Section: Methodsmentioning

confidence: 99%

Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities

et al. 2015

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a b s t r a c tIntroduction: The evidence on the effectiveness of rehabilitation in lung cancer patients is limited. Whole body vibration (WBV) has been proposed as an alternative to conventional resistance training (CRT). Methods: We investigated the effect of radical treatment (RT) and of two rehabilitation programmes in lung cancer patients. The primary endpoint was a change in 6-min walking distance (6MWD) after rehabilitation. Patients were randomised after RT to either CRT, WBVT or standard follow-up (CON). Patients were evaluated before, after RT and after 12 weeks of intervention. Results: Of 121 included patients, 70 were randomised to either CON (24), CRT (24) or WBVT (22). After RT, 6MWD decreased with a mean of 38 m (95% CI 22-54) and increased with a mean of 95 m (95% CI 58-132) in CRT (p < 0.0001), 37 m (95% CI −1-76) in WBVT (p = 0.06) and 1 m (95% CI −34-36) in CON (p = 0.95), respectively. Surgical treatment, magnitude of decrease in 6MWD by RT and allocation to either CRT or WBVT were prognostic for reaching the minimally clinically important difference of 54 m increase in 6MWD after intervention. Conclusions: RT of lung cancer significantly impairs patients' exercise capacity. CRT significantly improves and restores functional exercise capacity, whereas WBVT does not fully substitute for CRT.

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“…The benefits of PR have been extensively reported in patients with chronic obstructive pulmonary disease (COPD), with the assumption that the recommendations are applicable to subjects with other lung diseases [4,5]. Benefits of PR in COPD patients are reported in view of decreased dyspnoea, increased exercise endurance, improved HRQL and reduced healthcare costs [5][6][7][8][9]. However, data supporting PR in patients with ILD are scarce and the effects of PR in patients with ILD are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Effects of inpatient pulmonary rehabilitation in patients with interstitial lung disease

Huppmann

Sczepanski²,

Boensch³

et al. 2012

Eur Respir J

161

110

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Pulmonary rehabilitation is recommended for patients with chronic lung diseases including idiopathic pulmonary fibrosis according to international guidelines. However, data for patients with interstitial lung disease (ILD) are limited. We examined the effect of an inpatient pulmonary rehabilitation on functional status and quality of life in ILD patients.We evaluated 402 consecutive ILD patients who were admitted to a specialised pulmonary rehabilitation centre (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010). All patients performed a standardised pulmonary rehabilitation programme including pulmonary function tests, blood-gas analysis, 6-min walk test (6MWT), dyspnoea rating and health-related quality of life questionnaire (the 36-item short-form health survey; SF-36) on admission and discharge.Mean duration of pulmonary rehabilitation was 30¡1 days. 6MWT distance improved by 46¡3 m (308¡6 m versus 354¡6 m; p,0.001). Dyspnoea rating did not change. Lung function testing showed marginal improvement of vital capacity (+1¡0%; p50.002). The SF-36 questionnaire demonstrated an increase in all eight sub-scores as well as in the physical and mental health summary scores (physical 6¡1 points, p,0.001; mental health 10¡1 points, p,0.001). Moreover, patients with signs of pulmonary hypertension also benefited from pulmonary rehabilitation.In a large cohort of patients with ILD, pulmonary rehabilitation had a positive impact on functional status and quality of life. Considering the limited treatment options in this patient population pulmonary rehabilitation appears to be a valuable adjunct therapy. @ERSpublications Pulmonary rehabilitation improved functional status and QoL in a large cohort of ILD patients and appears to be a valuable adjunct therapy

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The Effects of Pulmonary Rehabilitation in the National Emphysema Treatment Trial

Cited by 175 publications

References 16 publications

Pulmonary Rehabilitation: A Retrospective Study in Eastern North Carolina

Pulmonary Rehabilitation: A Retrospective Study in Eastern North Carolina

Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities

Effects of inpatient pulmonary rehabilitation in patients with interstitial lung disease

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