The Effects of Psychological Stress on Depression

Yang, Longfei; Zhao, Ye; Wang, Yicun; Liu, Lei; Zhang, Xingyi; Li, Bingjin; Cui, Ranji

doi:10.2174/1570159x1304150831150507

Cited by 441 publications

(354 citation statements)

References 113 publications

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“…There were no significant differences in age, sex or percentage of comorbidities between the two groups. More patients in the COVID-19 suspected group received benzodiazepines (12,57.1%) than in the clean group (5,16.7%), and the difference was statistically significant (p=0.003). Compared with patients in the clean group, patients in the COVID-19 suspected group had significantly higher PSS, HAMD, HAMA and PSQI scores.…”

Section: Comparison Between Covid-19 Suspected and Clean Groupsmentioning

confidence: 91%

Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease (COVID-19) in Hubei Province, China

Liu¹,

Lin

Jiang

et al. 2020

Gen Psych

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BackgroundSince the outbreak of COVID-19, no data have been available for hospitalised psychiatric patients who are suspected to have COVID-19. We performed a comprehensive investigation of the clinical features of hospitalised patients with schizophrenia with or without suspected COVID-19 in Hubei Province, China.AimTo explore the clinical characteristics of hospitalised patients with schizophrenia with suspected COVID-19 in Hubei Province, China.Methods21 hospitalised patients with schizophrenia with suspected COVID-19 (COVID-19 suspected group) in the isolation ward of a mental health hospital in Wuhan and 30 hospitalised patients with schizophrenia (clean group) in the general ward of another mental health hospital in Yichang were recruited. We retrospectively reviewed their clinical characteristics, laboratory findings and chest CT results before 21 February 2020. We also compared the emotional and mental symptoms between the two groups.ResultsMedical records revealed that 21 COVID-19 suspected patients were transferred to the isolation ward between 30 January 2020 and 15 February 2020. The mean age (SD) of COVID-19 suspected patients was 43.1 (2.6). 12 (57.1%) patients showed abnormalities on chest CT before onset of respiratory symptoms. 14 (66.7%) patients had psychiatric medications adjustment after detection of abnormal chest CT findings. By 21 February, one patient was confirmed to have COVID-19. Even though the remaining 20 (95.2%) were negative for at least two reverse transcription PCR tests, 11 (52.4%) patients met the diagnostic criteria for clinically confirmed cases. Compared with patients in the clean group, patients in the suspected COVID-19 group showed significantly higher stress, depression and anxiety levels and poorer sleep quality.ConclusionSetting up an independent isolation ward for hospitalised psychiatric patients who are suspected to have symptoms of COVID-19 helped control the spread of the epidemic. Patients with schizophrenia suspected to have COVID-19 showed increased stress and mood and sleep disturbances, which should be appropriately managed.

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Section: Comparison Between Covid-19 Suspected and Clean Groupsmentioning

confidence: 91%

Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease (COVID-19) in Hubei Province, China

Liu¹,

Lin

Jiang

et al. 2020

Gen Psych

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“…Chronic stress is a considerable health concern for society, associated with various disease states including an increased risk of neuropsychiatric disorders like depression (Yang et al . ; Ramirez et al . ) and functional gastrointestinal disorders such as irritable bowel syndrome (Stam et al .…”

Section: Introductionmentioning

confidence: 99%

“…Considering that these behavioural parameters are negatively affected by chronic (psychosocial) stress (Yang et al . ; Ramirez et al . ), we hypothesised that SCFA supplementation could ameliorate these psychosocial stress‐induced behavioural deficits.…”

Section: Introductionmentioning

confidence: 99%

Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations

Wouw

Boehme

Lyte

et al. 2018

The Journal of Physiology

523

309

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There is a growing recognition of the involvement of the gastrointestinal microbiota in the regulation of physiology and behaviour. Microbiota-derived metabolites play a central role in the communication between microbes and their host, with short-chain fatty acids (SCFAs) being perhaps the most studied. SCFAs are primarily derived from fermentation of dietary fibres and play a pivotal role in host gut, metabolic and immune function. All these factors have previously been demonstrated to be adversely affected by stress. Therefore, we sought to assess whether SCFA supplementation could counteract the enduring effects of chronic psychosocial stress. C57BL/6J male mice received oral supplementation of a mixture of the three principle SCFAs (acetate, propionate and butyrate). One week later, mice underwent 3 weeks of repeated psychosocial stress, followed by a comprehensive behavioural analysis. Finally, plasma corticosterone, faecal SCFAs and caecal microbiota composition were assessed. SCFA treatment alleviated psychosocial stress-induced alterations in reward-seeking behaviour, and increased responsiveness to an acute stressor and in vivo intestinal permeability. In addition, SCFAs exhibited behavioural test-specific antidepressant and anxiolytic effects, which were not present when mice had also undergone psychosocial stress. Stress-induced increases in body weight gain, faecal SCFAs and the colonic gene expression of the SCFA receptors free fatty acid receptors 2 and 3 remained unaffected by SCFA supplementation. Moreover, there were no collateral effects on caecal microbiota composition. Taken together, these data show that SCFA supplementation alleviates selective and enduring alterations induced by repeated psychosocial stress and these data may inform future research into microbiota-targeted therapies for stress-related disorders.

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“…The loss of interest and pleasure in daily life and feelings of guilt, uselessness, and self‐punishment, low self‐esteem, loss of confidence, and lack of support may be identified, in addition to suicidal ideas and attempted self‐aggression or suicide. Cognitive changes include lack of concentration and reduced attention, recurrent pessimistic and negative thoughts about the individuals themselves relative to the past and future …”

Section: Introductionmentioning

confidence: 99%

“…Cognitive changes include lack of concentration and reduced attention, recurrent pessimistic and negative thoughts about the individuals themselves relative to the past and future. [1][2][3] It is believed that by 2020, depression will be the second major cause of incapacity. 4 A prevalence of depression of approximately 8% was verified in a population-based study (n = 3,003) conducted in Lethonia.…”

Section: Introductionmentioning

confidence: 99%