The effects of psychoactive drugs and neuroleptics on language in normal subjects and schizophrenic patients: a review

Salomé, F.; Boyer, Patrice; Fayol, Michel

doi:10.1016/s0924-9338(00)00520-4

Cited by 21 publications

(6 citation statements)

References 44 publications

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“…Chenery et al (2004) revealed an absence of priming for the RU condition in schizophrenia, despite priming for the UR and RR conditions. Accordingly, this result may be consistent with the alterations to dopaminergic activity reported in this population (see Salome, Boyer, & Fayol, 2000, for a review). Similarly, changes to dopaminergic activity in schizophrenia may also account for findings of an increased spreading of activation during semantic priming tasks (e.g., Moritz et al, 2001; Spitzer, Braun, Maier, Hermle, & Maher, 1993).…”

Section: Discussionsupporting

confidence: 91%

The influence of dopamine on semantic activation in Parkinson's disease: Evidence from a multipriming task.

Angwin¹,

Copland²,

Chenery³

et al. 2006

Neuropsychology

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Research has suggested that semantic processing deficits in Parkinson's disease (PD) are related to striatal dopamine deficiency. As an investigation of the influence of dopamine on semantic activation in PD, 7 participants with PD performed a lexical-decision task when on and off levodopa medication. Seven healthy controls matched to the participants with PD in terms of sex, age, and education also participated in the study. By use of a multipriming paradigm, whereby 2 prime words were presented prior to the target word, semantic priming effects were measured across stimulus onset asynchronies (SOAs) of 250 ms and 1,200 ms. The results revealed a similar pattern of priming across SOAs for the control group and the PD participants on medication. In contrast, within-group comparisons revealed that automatic semantic activation was compromised in PD participants when off medication. The implications of these results for the neuromodulatory influence of dopamine on semantic processing in PD are discussed.

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Section: Discussionsupporting

confidence: 91%

The influence of dopamine on semantic activation in Parkinson's disease: Evidence from a multipriming task.

Angwin¹,

Copland²,

Chenery³

et al. 2006

Neuropsychology

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“…Others have described several of these cognitive and physiological symptoms after ketamine and have speculated about their association with schizophrenia symptoms (Adler et al, 1999;Salomé et al, 2000;Krystal et al, 2003).…”

Section: Biological Theories Of Schizophrenia and Their Relation To Lmentioning

confidence: 99%

Does ketamine mimic aspects of schizophrenic speech?

et al. 2007

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Speech disturbances are well-known symptoms contributing to the diagnosis of schizophrenia. Subanesthetic doses of the N-methyl-D-aspartate (NMDA) antagonist ketamine have been reported to produce positive and negative symptoms and cognitive impairments consistent with those seen in schizophrenia. Insofar as this is true, it constitutes evidence that the NMDA system is involved in schizophrenia. It is therefore of interest to know whether ketamine produces speech disturbances like those of schizophrenia. Quantitative computer-aided analysis of apparently normal speech can detect clinically relevant changes and differences that are not noticeable to the human observer. Accordingly, in this study, speech samples were analysed for repetitiousness, idea density, and verb density using software developed by the authors. The samples came from two experiments, a within-subjects study of healthy volunteers given intravenous ketamine versus placebo, and a between-groups study of patients diagnosed with schizophrenia and comparable healthy controls.Our primary hypothesis was that in both schizophrenia and ketamine, repetitiousness would increase, since perserverative speech is a well-known symptom of schizophrenia. Our secondary hypotheses were that in both schizophrenia and ketamine, idea density and verb density would decrease as indicators of cognitive impairment. The primary hypothesis was confirmed in the schizophrenia experiment (between groups) and the ketamine experiment (within subjects). The secondary hypotheses were disconfirmed except that in the ketamine experiment, verb density was significantly lowered. Reduced use of verbs apparently reflects a cognitive impairment of a different type than repetitiousness, and further investigation is needed to determine whether this impairment occurs in psychosis.

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“…например, Кибрик, Подлесская, 2009). В то же время речь человека может изменяться и в течение небольшого отрезка времени под влиянием эмоций Сидоров, Филатова, 2012), после принятия психоактивных веществ (Salomé et al, 2000;Сухих, 2006), при сильном стрессе или от усталости.…”

Section: Introductionunclassified

Effect of Speaker’s Fatigue on Features of Spoken Discourse

Mariya¹

2020

RJCS

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In clinical linguistics, spoken discourse analysis is a crucial part of diagnostics as well as fundamental research of speech produced by people with various language impairments. The most common features for assessment are speech fluency, speech failures, errors, and syntactic complexity measures. However, several studies have shown that some of these parameters can be affected by fatigue or physical stress. Our study on narrative and procedural spoken discourse by healthy speakers with different levels of fatigue has shown a significant effect of fatigue level on speech tempo, and the elicitation task significantly affected multiple characteristics of spoken discourse

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The effects of psychoactive drugs and neuroleptics on language in normal subjects and schizophrenic patients: a review

Cited by 21 publications

References 44 publications

The influence of dopamine on semantic activation in Parkinson's disease: Evidence from a multipriming task.

The influence of dopamine on semantic activation in Parkinson's disease: Evidence from a multipriming task.

Does ketamine mimic aspects of schizophrenic speech?

Effect of Speaker’s Fatigue on Features of Spoken Discourse

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