The effects of progesterone therapy in pregnancy: vaginal and intramuscular administration

Hantoushzadeh, Sedigheh; Sheikh, Mahdi; Shariat, Mamak; Mansouri, Roodabeh; Ghamari, Azin; Golshahi, Fatemeh

doi:10.1080/14767058.2019.1656190

Cited by 5 publications

(6 citation statements)

References 41 publications

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“…The dramatic decrease in progesterone from the third trimester to postpartum was unrelated to changes in REM sleep parameters [ 62 ]. In a randomized clinical trial, pregnant women with previous preterm birth received either vaginal or intramuscular progesterone, but neither vaginal nor intramuscular progesterone improved sleep disturbances [ 86 ].…”

Section: Resultsmentioning

confidence: 99%

Sleep Disturbances Across a Woman's Lifespan: What Is the Role of Reproductive Hormones?

Haufe

Leeners

2023

Journal of the Endocrine Society

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Fluctuations of reproductive hormones are associated with various forms of sleep disturbances and specific sleep disorders, e.g. insomnia or sleep-disordered breathing, across different stages of reproductive ageing. During the menstrual cycle, sleep is particularly disrupted during the late luteal phase as demonstrated by both objective and subjective measurements of sleep. Progesterone and its metabolites generally have sleep promoting effects. A steep decline in progesterone, e.g. during the late luteal phase, is associated with sleep disruption. Endogenous estrogen shows no clear correlation with sleep alterations in relation to the menstrual cycle. During pregnancy, sleep disruption is not associated with changes in estrogen or progesterone but rather with changing physiological factors, e.g. nocturnal micturition, gastroesophageal reflux or musculoskeletal discomfort, all substantial factors that most likely mask any effect of hormones. Both endogenous and exogenous estrogen, as well as progesterone, are positively associated with sleep during the menopausal transition. A marked improvement of sleep disturbances is observed with perimenopausal hormone therapy. As this effect is not seen in younger women receiving contraceptive therapy, other causes of sleep disturbances, e.g. ageing and related changes in metabolism of stress hormones, secondary effects of vasomotor symptoms or depression, must be considered. Gonadotropins are less associated with sleep disturbances than ovarian hormones, except for during the menopausal transition where follicle-stimulating hormone (FSH) is related to sleep disruption. Further, hyperandrogenism, as seen in women with polycystic ovary syndrome (PCOS), is associated with sleep disturbances and specific sleep disorders, e.g. obstructive sleep apnea (OSA).

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Section: Resultsmentioning

confidence: 99%

Sleep Disturbances Across a Woman's Lifespan: What Is the Role of Reproductive Hormones?

Haufe

Leeners

2023

Journal of the Endocrine Society

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“…Previous randomized clinical trials also reported significantly increased psychosocial disorders at 24 weeks' gestation after periods of either vaginal or intramuscular progesterone use in pregnant women. 9 Thus, more important factors to consider in the real-life situation may include further need assessment from women on their perception and satisfaction with its use.…”

Section: Barriers To Adherence To Vaginal Progesterone Treatmentmentioning

confidence: 99%

“…Other factors that could lead to noncompliance may include the physical impact of the medication like irritation or discomfort on the pelvis from frequent administration, the risk of pelvic trauma during repeated insertion, the timing of administration, conflict with intercourse, and so on. Previous randomized clinical trials also reported significantly increased psychosocial disorders at 24 weeks’ gestation after periods of either vaginal or intramuscular progesterone use in pregnant women . Thus, more important factors to consider in the real-life situation may include further need assessment from women on their perception and satisfaction with its use.…”

Section: Barriers To Adherence To Vaginal Progesterone Treatmentmentioning

confidence: 99%

Evaluating Vaginal Progesterone in Preventing Recurrent Preterm Birth: A Call to Action

Akinwunmi

Ming

2022

JAMA Netw Open

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“…There was an increase in emotional distress scores at 8 weeks post intervention compared with baseline in both groups. However, the groups were not compared with one another in terms of this outcome, nor were there any placebo groups [129].…”

Section: Mood Effects Of Progesterone and Progestins On Psychiatric Symptoms Across The Reproductive Lifespanmentioning

confidence: 99%

Progesterone, reproduction, and psychiatric illness

Standeven

McEvoy

Osborne

2020

Best Practice & Research Clinical Obstetrics & Gynaecol

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The effects of progesterone therapy in pregnancy: vaginal and intramuscular administration

Cited by 5 publications

References 41 publications

Sleep Disturbances Across a Woman's Lifespan: What Is the Role of Reproductive Hormones?

Sleep Disturbances Across a Woman's Lifespan: What Is the Role of Reproductive Hormones?

Evaluating Vaginal Progesterone in Preventing Recurrent Preterm Birth: A Call to Action

Progesterone, reproduction, and psychiatric illness

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