The effects of progesterone and ovariectomy on mammary tumours induced by 7,12-Dimethylbenz(A) anthracene in Sprague-Dawley rats

Jabara, Anne G.; Harcourt, Alison G.

doi:10.3109/00313027009077333

Cited by 17 publications

(7 citation statements)

References 25 publications

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“…Progesterone, one of the main hormones produced by the corpus luteum (200), when implanted in female rats increases the frequency of both MCA-and DMBA-induced mammary tumors in either intact or ovariectomized rats but does not do so in ovariectomized-adrenalectomized rats (25,27,64,65,(201)(202)(203)(204)(205). Chronic administration of progesterone to neonatally androgenized rats at varying times after DMBA treatment causes a marked increase in development and growth of mammary carcinomas (101); however, moderate to high doses of this hormone, in combination with high doses of estrogen, inhibit the growth of DMBAinduced rat carcinoma (28).…”

Section: Ovarian Steroid Hormones and Growth Factorsmentioning

confidence: 99%

Mammary Gland Neoplasia in Long-Term Rodent Studies

Russo¹,

Russo²

1996

Environmental Health Perspectives

121

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Section: Ovarian Steroid Hormones and Growth Factorsmentioning

confidence: 99%

Mammary Gland Neoplasia in Long-Term Rodent Studies

Russo¹,

Russo²

1996

Environmental Health Perspectives

121

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“…The steroid hormone has been implicated in both the genesis and the extinction of experimentally induced mammary tumors (2)(3)(4)(5). In women, progesterone is often considered to have a protective effect against cancer development (6) and the presence of progesterone receptors (PR) in human breast cancer is associated with hormone dependence and prolonged survival (7,8).…”

mentioning

confidence: 99%

The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2.

Law¹,

Kao²,

Wei³

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

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Progesterone is involved in the development and progression of breast cancers, and progesterone receptors (PR) are important markers of hormone dependence and disease prognosis. We have used a human PR cDNA probe, genomic DNA blotting of a series of Chinese hamster-human cell hybrids, and in situ hybridization to map the human PR gene to chromosome 11, band q13. This band also contains the human homolog of the mouse mammary tumor virus integration site, int-2, which surrounds a protooncogene thought to be involved in the development of murine mammary cancers. That these two genes share the same chromosomal location raises important questions about their possible linkage and about the relationship between the mammary-specific oncogene and the steroid hormone in the development, growth, and hormone dependence of human breast cancers.

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“…In contrast, when daily progesterone injections were begun either 2 days before or 2 days after feeding DMBA and were continued until the end of the experiment (135 or 195 days), a significant enhancement in mammary carcinogenesis was obtained (Jabara & Harcourt, 1970;Jabara et al, 1973).…”

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Effects of progesterone on mammary carcinogenesis by DMBA applied directly to rat mammae

Jabara¹,

Marks²,

Summers³

et al. 1979

Br J Cancer

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Summary.-The effects and site(s) of action of progesterone on DMBA mammary carcinogenesis in the rat, when a small dose of the carcinogen was applied directly to the inguinal mammary gland, were investigated.No reduction in tumour yield was apparent when progesterone was administered s.c. for 18 days before dusting DMBA. This finding contrasts with a previously reported inhibitory effect on carcinogenesis when hormone treatment was followed by intragastric administration of DMBA.When progesterone injections were begun either 2 days before or 2 days after direct application of DMBA, and were continued until the end of the experiment (135 or 195 days) an enhancement in carcinogenesis was observed similar to that previously demonstrated after gastric intubation of DMBA.These findings, together with previously reported observations, suggest that progesterone may exert its inhibitory effect on carcinogenesis by acting at a site outside the breast, perhaps on the liver. However, it is likely that the hormone acts directly on the mammary tissue to exert its enhancing effect on tumorigenesis.

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The effects of progesterone and ovariectomy on mammary tumours induced by 7,12-Dimethylbenz(A) anthracene in Sprague-Dawley rats

Cited by 17 publications

References 25 publications

Mammary Gland Neoplasia in Long-Term Rodent Studies

Mammary Gland Neoplasia in Long-Term Rodent Studies

The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2.

Effects of progesterone on mammary carcinogenesis by DMBA applied directly to rat mammae

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