The Effects of Probiotic Supplements on Blood Markers of Endotoxin and Lipid Peroxidation in Patients Undergoing Gastric Bypass Surgery; a Randomized, Double-Blind, Placebo-Controlled, Clinical Trial with 13 Months Follow-Up

Mokhtari, Zeinab; Karbaschian, Zohreh; Pazouki, Abdolreza; Kabir, Ali; Hedayati, Mehdi; Mirmiran, Parvin; Hekmatdoost, Azita

doi:10.1007/s11695-018-03667-6

Cited by 35 publications

(22 citation statements)

References 46 publications

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“…In contrast, the synbiotic intervention trial in pregnant women using Bifidobacterium animalis lactis HN019 and inulin did not show an improvement in vitamin D status [ 54 ]. The inconsistent results may be due to differences between study populations, and the use of different strains ( L. reuteri [ 14 ], B. animalis [ 54 ], and multi-strain probiotics) [ 30 , 55 ], doses and durations of intervention. Therefore, larger well-designed RCTs are needed to reach a consensus on the effects of probiotic supplementation on vitamin D status.…”

Section: Resultsmentioning

confidence: 99%

“…In the above mentioned pediatric trial [50], an increase in vitamin D status was indicated with the synbiotic treatment; however, the p values were not reported. In concert with the latter study, an increase in vitamin D status as assessed by serum 25-hydroxy vitamin D3 was observed after L. reuteri NCIMB30242 consumption [14] and following multi-strain probiotic consumption in two studies with bariatric surgery patients [30,55]. In contrast, the synbiotic intervention trial in pregnant women using Bifidobacterium animalis lactis HN019 and inulin did not show an improvement in vitamin D status [54].…”

Section: Probiotic Supplementation and Fat-soluble Vitamin And Carotenoid Statusmentioning

confidence: 96%

“…The ability of probiotics to increase micronutrient absorption [ 13 , 24 , 25 ] and status [ 16 , 26 , 27 , 28 , 29 ] has been examined extensively in both animal models and clinical studies. Improvements in nutrient status following administration of certain probiotics have been noted regarding B-group vitamins (folate and B12) [ 30 , 31 , 32 ], and minerals (iron and calcium) [ 29 , 33 , 34 , 35 ]. To date, mixed results of probiotic supplementation have been reported from clinical trials across the different micronutrients.…”

Section: Introductionmentioning

confidence: 99%

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Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials

et al. 2021

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Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of probiotic supplementation to improve micronutrient status in healthy subjects. The authors searched for published English language peer-reviewed journal articles in PubMed, Scopus, Embase, and Google Scholar databases from inception to July 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of eligible studies was assessed using the Revised Cochrane Risk-of-Bias tool (RoB)2 and Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-I tool). Fourteen original studies out of 2790 met the inclusion criteria. The results indicated that, despite varying degrees of efficacy, the intake of certain probiotics in healthy subjects was associated with a positive impact on the status of certain micronutrients (vitamin B12, calcium, folate, iron and zinc). A limitation was that studies were widely heterogeneous in terms of participant age, probiotic strain, species, dosage, intervention duration, and form of administration. Additional clinical trials are warranted to determine the most effective strains of probiotics, doses and durations of interventions.

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Section: Resultsmentioning

confidence: 99%

Section: Probiotic Supplementation and Fat-soluble Vitamin And Carotenoid Statusmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials

et al. 2021

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“…LPS as an endotoxin and in ammation marker with short half-life, is produced and released to blood circulation by gut microbiome and binds to LBP. High levels of LPS and LBP is representative of altered gut microbiome (24,25).…”

Section: Discussionmentioning

confidence: 99%

“…Lipopolysaccharide Binding Protein (LBP) is an acute phase protein produced by the liver which binds to LPS and is a part of LPS-induced in ammation. Serum LBP can be measured to evaluate changes in the gut microbiome (24,25).On the other hand, two previous clinical trials documented that TRF might have a favorable effects on weight loss, reduction of insulin resistance, systolic blood pressure and fasting glucose levels (26). However some previous studies did not show any advantages of using TRF on body weight management (27,28).Therefore, these aforementioned discrepancies may be somehow explainable by ignoring the role of feeding behavior disorders such as food addiction on body weight management.…”

Section: Background and Rationalementioning

confidence: 99%

Effect of Time Restricted Feeding on Anthropometric Measures, Body Composition, Eating Behavior, Stress, Brain Derived Neurotrophic Factor (BDNF) and Lipopolysaccharide Binding Protein (LBP) Levels in Food Addicted Over Weight and Obese Women: A Study Protocol for a RRandomized Clinical Trial

Irani

Khodami

Abiri

et al. 2021

Preprint

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Background: Food addiction, the desire to eat compulsively and excessively palatable foods, is one of the behavioral factors that plays an important role in pathogenesis of obesity. Food addiction, like drug addiction, changes the dopaminergic system in rewards region of brain, but at lower levels. There are evidence suggesting brain-derived neurotrophic factor (BDNF) is synthesized in dopaminergic pathways in the reward regions of the brain and is involved in regulating food intake and body weight. BDNF is also associated with eating disorders in humans and hyperphagia in mice. On the other hand, it has been shown that the intestinal microbiome is effective in eating behavior through the production of neuronal and hormonal mediators, including BDNF. Intestinal microbiome changes greatly under the influence of diet. It has been shown that a time-restricted feeding (TRF) has been able to maintain fluctuations in the intestinal microbiome in response to the body's circadian rhythm. Furthermore, increased pathogens in the gut are associated with increased release of polysaccharides from the bacterial wall, resulting in increased levels of lipopolysaccharide binding protein (LBP). This study will aim to evaluate the effect of TRF on anthropometric measures, body composition, eating behavior, stress level, BDNF and LBP levels in over weight and obese women with food addiction.Methods/design: we will carry on a randomized clinical trial for 8 weeks to evaluate the effect of a TRF on anthropometric measures, body composition, eating behavior, stress level, BDNF and LBP levels in obese and overweight women with food addiction.Discussion: Given the effect of BDNF on regulating eating behavior and body weight and the effect of dietary restrictions on BDNF and the gut microbiome, the TRF diet could possibly be a new way to successfully manage weight through modifying BDNF in people with eating disorders, including food addiction.Trial Registration: Iranian Registry of Clinical Trials. IRCT20131228015968N7. Registered on 2020-10-25.

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Lactobacillus rhamnosus GG Promotes Intestinal Vitamin D Absorption by Upregulating Vitamin D Transporters in Senile Osteoporosis

et al. 2022

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The Effects of Probiotic Supplements on Blood Markers of Endotoxin and Lipid Peroxidation in Patients Undergoing Gastric Bypass Surgery; a Randomized, Double-Blind, Placebo-Controlled, Clinical Trial with 13 Months Follow-Up

Cited by 35 publications

References 46 publications

Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials

Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials

Effect of Time Restricted Feeding on Anthropometric Measures, Body Composition, Eating Behavior, Stress, Brain Derived Neurotrophic Factor (BDNF) and Lipopolysaccharide Binding Protein (LBP) Levels in Food Addicted Over Weight and Obese Women: A Study Protocol for a RRandomized Clinical Trial

Lactobacillus rhamnosus GG Promotes Intestinal Vitamin D Absorption by Upregulating Vitamin D Transporters in Senile Osteoporosis

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