The Effects of Probiotic Honey Consumption on Metabolic Status in Patients with Diabetic Nephropathy: a Randomized, Double-Blind, Controlled Trial

Abstract

To the best of our knowledge, this study is the first evaluating the effects of probiotic honey intake on glycemic control, lipid profiles, biomarkers of inflammation, and oxidative stress in patients with diabetic nephropathy (DN). This investigation was conducted to evaluate the effects of probiotic honey intake on metabolic status in patients with DN. This randomized, double-blind, controlled clinical trial was performed among 60 patients with DN. Patients were randomly allocated into two groups to receive either 25 g/day probiotic honey containing a viable and heat-resistant probiotic Bacillus coagulans T11 (IBRC-M10791) (10 CFU/g) or 25 g/day control honey (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and 12 weeks after supplementation to quantify glycemic status, lipid concentrations, biomarkers of inflammation, and oxidative stress. After 12 weeks of intervention, patients who received probiotic honey compared with the control honey had significantly decreased serum insulin levels (- 1.2 ± 1.8 vs. - 0.1 ± 1.3 μIU/mL, P = 0.004) and homeostasis model of assessment-estimated insulin resistance (- 0.5 ± 0.6 vs. 0.003 ± 0.4, P = 0.002) and significantly improved quantitative insulin sensitivity check index (+ 0.005 ± 0.009 vs. - 0.0007 ± 0.005, P = 0.004). Additionally, compared with the control honey, probiotic honey intake has resulted in a significant reduction in total-/HDL-cholesterol (- 0.2 ± 0.5 vs. + 0.1 ± 0.1, P = 0.04). Probiotic honey intake significantly reduced serum high-sensitivity C-reactive protein (hs-CRP) (- 1.9 ± 2.4 vs. - 0.2 ± 2.7 mg/L, P = 0.01) and plasma malondialdehyde (MDA) levels (- 0.1 ± 0.6 vs. + 0.6 ± 1.0 μmol/L, P = 0.002) compared with the control honey. Probiotic honey intake had no significant effects on other metabolic profiles compared with the control honey. Overall, findings from the current study demonstrated that probiotic honey consumption for 12 weeks among DN patients had beneficial effects on insulin metabolism, total-/HDL-cholesterol, serum hs-CRP, and plasma MDA levels, but did not affect other metabolic profiles. http://www.irct.ir : IRCT201705035623N115.

Effect of probiotics supplementation on glucose and oxidative stress in type 2 diabetes mellitus: a meta-analysis of randomized trials

“…One hypothesis is that probiotics improve glucose level in diabetic patients via inhibition of oxidative stress [41]. Only some studies attempted to evaluate the oxidative stress biomarkers to investigate its potential association with intestinal microbiota on glycemic control [10,14,22,[27][28][29][30][31][32][33][34][35][36]. The reported antioxidant activity in several previous animal studies was shown in particular strains of lactic acid bacteria such as B. lactis, L. acidophilus, L. plantarum and L. casei [43][44][45].…”

“…Our initial search yielded 435 articles. After screening abstracts and full texts, 13 randomized clinical trials (RCTs) were included which involved 840 subjects with T2DM [10,14,22,[27][28][29][30][31][32][33][34][35][36]. The number of the initial search results and included studies are shown in Fig.…”

Probiotics ameliorates glycemic control of patients with diabetic nephropathy: A randomized clinical study

“…40 In addition, Ejtahed et al 41 It was reported that probiotic honey consumption for 12 weeks among DN patients had beneficial effects on insulin metabolism, total-/HDL-cholesterol, serum hs-CRP, and plasma MDA levels, but did not affect other metabolic profiles. 43 Another study showed that probiotic supplementation had beneficial effects on glycemic control and markers of cardiometabolic risk. 44 A meta-analysis showed that probiotic supplementation decreased serum insulin and insulin resistance, but it had no beneficial effect regarding kidney function, body weight and lipid profiles, with a moderate positive effect regarding some oxidative stress biomarkers.…”

“…It was reported that probiotic honey consumption for 12 weeks among DN patients had beneficial effects on insulin metabolism, total‐/HDL‐cholesterol, serum hs‐CRP, and plasma MDA levels, but did not affect other metabolic profiles 43 . Another study showed that probiotic supplementation had beneficial effects on glycemic control and markers of cardiometabolic risk 44 .…”

The Case for a More Holistic Approach to Dry Eye Disease: Is It Time to Move beyond Antibiotics?

“…Some of the oligosaccharides in honey are prebiotics [163]. Probiotic honey (honey enriched with probiotics) had a beneficial effect on marks of insulin metabolism and markers of inflammation in subjects with diabetic nephropathy [164]. For ocular use, Aristotle wrote of honey being a salve for sore eyes [165] along with ancient honey remedies for eye disease spans Attica, Europe, India, Asia and Africa [166].…”