The effects of prenatal and postnatal protein malnutrition on physical and motor development of the rat

Sykes, S. E.; Cheyne, Julián Andrés Ramírez

doi:10.1002/dev.420090312

Cited by 17 publications

(4 citation statements)

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“…natal malnutrition affected growth of mice, prenatal malnutri-Psychologists have reported a number of effects of malnutrition experienced by infant laboratory rats and mice on the subsequent reproduction (Sykes and Cheyne 1976;Huck et al 1986), reflexes (Smart and Dobbing 197 I), problem-solving ability (Bush and Leathwood 1975), and social behaviour (Frankovi 1973;Randt et al 1975;Whatson et al 1976) of well-nourished adults. Ecologists, however, have generally not considered the long-term effects of infant malnutrition on populations (but see Andreassen and Ims 1990;and Mech et al 1991).…”

Section: Introductionmentioning

confidence: 99%

“…Low-protein diets administered prenatally (Bush and Leathwood 1975;Schenck et al 1978) and during the suckling period cause severe and permanent impairment of growth in rats and mice (Smart and Dobbing 197 1 ;Letvisky and Barnes 1972;Stewart et al 1975;Sykes and Cheyne 1976;Whatson et al 1976;Whatson and Smart 1978;Martin et al 1987). In white mice, postweaning malnutrition followed by adequate nutrition results in an almost complete catch-up in weight (Bush and Leathwood 1975;McKiggan 1990).…”

Section: Introductionmentioning

confidence: 99%

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Long-term effects of infant malnutrition on the behaviour of adult meadow voles, Microtus pennsylvanicus

Wong¹,

Bondrup‐Nielsen²

1992

Can. J. Zool.

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WONG, K. L., and BONDRUP-NIELSEN, S. 1992. Long-term effects of infant malnutrition on the behaviour of adult meadow voles, Microtus pennsylvanicus. Can. J . Zool. 70: 1304 -1308. Several studies on laboratory mice and rats have shown that malnutrition during infancy has a variety of long-term effects extending into adulthood. These effects are manifested in reproduction, including reduced litter sizes, reduced growth rates of the young, and skewed sex ratios, and in behaviour, including increased nervousness, decreased problem-solving ability, and reduced pup retrieval to the nest by the mother. This study investigated the effects of early malnutrition on behaviour in adult meadow voles, Microtus pennsylvanicus. Experimental animals received a standard diet diluted with pure cornstarch (1 part standard diet to 2 parts pure cornstarch) through their mothers during lactation and directly for 3 weeks postweaning. Control individuals always received the standard diet ad libitum. The cumulative duration of 13 behaviours was measured in 10-min trial periods and compared between experimental and control animals. Experimental females differed from control females in a number'of behaviours, especially those involving high activity levels, whereas experimental and control males showed little difference in the behaviours performed. The behaviour profile of previously malnourished females was similar to those of both control and experimental males. Increased activity, resulting from poor nutrition, may have consequences for dispersal and spacing behaviour . WONG, K. L., et BONDRUP-NIELSEN, S. 1992. Long-term effects of infant malnutrition on the behaviour of adult meadow voles, Microtus pennsylvanicus. Can. J . Zool. 70: 1304 -1308. Plusieurs Ctudes sur les souris et les rats de laboratoire ont dCmontrC que la malnutrition au cours du jeune Age entraine une kyrielle d'effets a long terme a l'ige adulte, notamment sur la reproduction, portCes plus petites, croissance ralentie des petits, rapports miles : femelles dCsCquilibrCs, et sur le comportement, nervositC accrue, capaciti moins grande de faire face a des problkmes, rCduction de la rCcupCration des petits dans le nid. Nous avons CtudiC les effets d'une malnutrition au cours du jeune i g e sur le comportement d'adultes du Campagnol des champs, Microtus pennsylvanicus. Les animaux expkrimentaux ont Ct C soumis a un rCgime standard diluC avec de la fCcule de mays pure (1 partie de regime et 2 parties de fkcule), par le lait de leur mkre au cours de l'allaitement, puis directement durant 3 semaines aprks le sevrage. Les individus tCmoins ont toujours r e p le rCgime standard ad libitum. La durCe cumulative de 13 comportements a CtC mesurCe au cours de pCriodes de 10 minutes et comparke chez les animaux expkrimentaux et les animaux tCmoins. Les femelles experimentales diffkrent des femelles tCmoins dans plusieurs de leurs comportements, particulikrement ceux qui requikrent une grande activitC, alors que les miles des deux groupes ont des comportements semblables. Le comporte...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-term effects of infant malnutrition on the behaviour of adult meadow voles, Microtus pennsylvanicus

Wong¹,

Bondrup‐Nielsen²

1992

Can. J. Zool.

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“…Our study indicated a positive relationship between dietary protein levels and activity. Similarly, protein-restriction reduced activity and exploratory behavior in mice and rat pups (Frankova, 1973;Frankova & Barnes, 1968;Pillay et al, 2016;Sykes & Cheyne, 1976;Watkins et al, 2008). In contrast, rats fed high protein diets for prolonged periods exhibit hyperactivity (Onaivi, Brock, & Prasad, 1992).…”

Section: Discussionmentioning

confidence: 99%

Protein deficiency decreases stereotypic behavior frequency and prevalence and activity in the striped mouse Rhabdomys dilectus chakae

Pillay

Rimbach

2017

Developmental Psychobiology

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Diverse motivational triggers, including diet, elicit stereotypic behavior. We investigated whether diets comprised of different protein levels but similar levels of energy were associated with the occurrence of locomotor stereotypies in the striped mouse Rhabdomys dilectus chakae. In a first experiment, 20 stereotypic and 20 non-stereotypic (10 subjects per sex and per group) juvenile (40 days old) subjects were placed on baseline (BP), high (HP) or low protein (LP) diet treatments (120 subjects in total). All subjects initially identified as stereotypic displayed stereotypic behavior in the BP and HP treatments on Days 60-63 and Days 80-83 compared to 35% and 12.5% of LP subjects, respectively. Moreover, LP subjects displayed lower levels of activity and stereotypic behavior than BP and HP subjects. Those identified as non-stereotypic never displayed stereotypy. In a second experiment, 48 individuals, bred and reared on LP and whose parents were stereotypic, were assigned to either HP (13 males, 12 females) or LP (12 males, 11 females) treatments at 50 days of age for 30 days. Stereotypy was three times less likely to occur in the LP than the HP treatment, and activity was greater in LP-HP individuals than LP-LP individuals. In both experiments, LP individuals had the lowest body mass. Striped mice adjusted their behaviors in response to dietary protein levels. Protein deficiency reduced activity and stereotypic behavior and prevalence, possibly related to an energy or neurological deficit.

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“…Head tremors have been reported in rat pups of food-restricted females (Simonson, Sherwin, Anilane, Yu, & Chow, 1969). Maternal undernutrition has also been shown to affect the development of specific reflexes and locomotor patterns in the young rat (Altman et al, 1970;Smart & Dobbing, 1971;Sykes & Cheyne, 1976) and cat (Simonson, 1979). Thus, impaired locomotor abilities may have been partially responsible for the delay observed in the development of home-orientation behavior in our restricted kittens.…”

Section: Discussionmentioning

confidence: 99%

Development of home orientation in offspring of protein‐restricted cats

Gallo

Werboff

Knox

1984

Developmental Psychobiology

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The development of home orientation was evaluated in 2-14-day-old kittens nursing from mothers fed a protein-restricted or control diet during late gestation and lactation. Although restricted kittens remained in the home when placed in it, their ability to return to the home was delayed when they were removed from it. Restricted kittens also exhibited aberrant locomotor development and an increased frequency of loss of balance (upsets) en route to the home. During postnatal Week 1, vocalization frequency, an index of kitten disturbance when outside the home, was increased in restricted kittens tested in the home, and in adjacent and diagonal corners. Restricted kittens persisted in vocalizing more frequently than controls in home and adjacent corner tests during Week 2. Taken together, these data suggest that maternal protein restriction during late gestation and lactation disrupts the development of home orientation behavior by impairing locomotor function and increasing emotional responsiveness.

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The effects of prenatal and postnatal protein malnutrition on physical and motor development of the rat

Cited by 17 publications

References 18 publications

Long-term effects of infant malnutrition on the behaviour of adult meadow voles, Microtus pennsylvanicus

Long-term effects of infant malnutrition on the behaviour of adult meadow voles, Microtus pennsylvanicus

Protein deficiency decreases stereotypic behavior frequency and prevalence and activity in the striped mouse Rhabdomys dilectus chakae

Development of home orientation in offspring of protein‐restricted cats

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