The effects of pregnancy on nasal physiology

Demir, Uygar; Demir, Bilge Çetinkaya; Oztosun, Ege; Uyanıklar, Özlem; Ocakoğlu, Gökhan

doi:10.1002/alr.21438

Cited by 20 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Frühere Arbeiten lehnten zunächst das Vorliegen eines eigenständigen Krankheitsbildes ab und sahen einen Zusammenhang zwischen subjektiv empfundenem emotionalen Stress und dem Auftreten einer SSR [14], [15]. Inzwischen ist allerdings der Einfluss der Schwangerschaft auf die Nasenatmung rhinologisch messbar, auch wenn sich nicht immer zeitgleich eine entsprechende SSR Symptomatik ausbildet [16], [17]. Verschiedene Studien versuchten eine Verbindung zwischen der hormonellen Umstellung des Körpers im Rahmen der Schwangerschaft und dem Auftreten einer SSR herzustellen [18]- [22].…”

Section: äTiologie and Pathophysiologieunclassified

Update Schwangerschaftsrhinitis

Friebe-Hoffmann

Lindemann

2018

Laryngo-Rhino-Otol

View full text Add to dashboard Cite

Pregnancy rhinitis (PR), a common condition in pregnant women, is defined as long-lasting nasal congestion due to mucosal swelling and increased secretion without any signs of infection, allergy or tumor, starting at any time during pregnancy and disappearing within 2 weeks of delivery. Smoking and a sensitization to house dust mites are known risk factors. While a definitive pathophysiological concept for PR does not exist, hormonal influences are discussed. We present a stepwise therapeutic strategy for PR and an overview to the latest literature.

show abstract

Section: äTiologie and Pathophysiologieunclassified

Update Schwangerschaftsrhinitis

Friebe-Hoffmann

Lindemann

2018

Laryngo-Rhino-Otol

View full text Add to dashboard Cite

show abstract

“…Frühere Arbeiten lehnten zunächst das Vorliegen eines eigenständigen Krankheitsbildes ab und sahen einen Zusammenhang zwischen subjektiv empfundenen emotionalem Stress und dem Auftreten einer SSR [14,15]. Inzwischen ist allerdings der Einfluss der Schwangerschaft auf die Nasenatmung rhinologisch messbar, auch wenn sich nicht immer zeitgleich eine entsprechende SSR Symptomatik ausbildet [16,17]. Verschiedene Studien versuchten eine Verbindung zwischen der hormonellen Umstellung des Körpers im Rahmen der Schwangerschaft und dem Auftreten einer SSR herzustellen [18][19][20][21][22].…”

Section: äTiologie and Pathophysiologieunclassified

Update Schwangerschaftsrhinitis

Friebe-Hoffmann

Lindemann

2016

Z Geburtshilfe Neonatol

View full text Add to dashboard Cite

show abstract

“…PR is a quite common gonadocorticoid related rhinological disorder 9-11 which may indirectly lead predisposition to comorbidities like maternal hypertension, preeclampsia, low APGAR score and fetal growth retardation 2,[6][7][8] . Although some epidemiological and physiological studies have been done on PR 3,42 , histopathological and biomolecular background has not been studied thoroughly. In addition, there are very few studies concerning the treatment of PR 43,44 .…”

Section: Discussionmentioning

confidence: 99%

Role of Nasal AQP5 And TREK1 Expression in Biomolecular Background of Pregnancy Rhinitis

Ülkümen¹

2020

jamp

View full text Add to dashboard Cite

Pregnancy rhinitis may lead predisposition to Obstructive Sleep Apnea Syndrome which is associated with critical comorbidities effecting both mother (preeclampsia, hypertension) and newborn (intrauterine growth retardation, low apgar score). We aim to unveil if nasal TREK-1 and AQP5 expression changes during pregnancy. We proposed that these two proteins may take part in the biomolecular background of Pregnancy Rhinitis. Twenty adult Wister albino female rats were enrolled into the study. Two groups constituted as 10 control (group A) and 10 pregnant (group B) rats. We sacrificed the rats at 21th day of gestation by intraperitoneal injection of 400mg/kg Na-pentobarbitone. Intracardiac blood sample was taken before the pulse died out. Serum estradiol (E2) and progesterone (PG) levels were determined by ELISA. Nasal septum with its mucoperichondrium was resected and sent for real time polymerase chain reaction testing. Relative TREK-1 (p=0.001) expression of group B was found to be significantly higher than group A. Relative AQP5 (p=0.003) expression was also found to be significantly higher in group B than group A. E2 was found to upregulate AQP5 expression (p=0.032) while downregulate TREK1 expression (p=-0.011). On the other hand, PG was also found to upregulate nasal AQP5 expression (p=0.024) but not TREK1 expression (p=-0.071). TREK1 and AQP5 take part in pregnancy related biomolecular changes of nasal mucosa. Namely, expression of TREK1 decreases while expression of AQP5 increases during pregnancy. These findings support the researchers asserting triggered allergy as the etiology of PR.

show abstract

The effects of pregnancy on nasal physiology

Cited by 20 publications

References 35 publications

Update Schwangerschaftsrhinitis

Update Schwangerschaftsrhinitis

Update Schwangerschaftsrhinitis

Role of Nasal AQP5 And TREK1 Expression in Biomolecular Background of Pregnancy Rhinitis

Contact Info

Product

Resources

About