The effects of predicted environmentally relevant concentrations of ZnO nanoparticles on the behavior of Gallus gallus domesticus (Phasianidae) chicks

Mesak, Carlos; Sampaio, Douglas Marcel dos Reis; Ferreira, Raíssa de Oliveira; Mendes, Bruna de Oliveira; Rodrigues, Aline Sueli de Lima; Malafaia, Guilherme

doi:10.1016/j.envpol.2018.08.004

Cited by 19 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown the cytotoxic and genotoxic damages caused by progressive Zn accumulation and distribution in the cytoplasm and nucleus of A. cepa (Kumari et al, 2011;Sun et al, 2019) and Vicia faba cells (Ghosh et al, 2016) after to exposure to high concentrations of ZnO NPs. Based on the present results, we can assume that low increase in accumulated Zn rates after the exposure to very low concentrations of ZnO NPs can have significant biological effect on plants and animals (Mesak et al, 2018;Souza et al, 2018).…”

Section: Bioaccumulation Analysissupporting

confidence: 56%

“…Although the aforementioned studies are relevant for environmental monitoring, they report the toxic effects of ZnO NPs at concentrations far from those found in the field; therefore, these concentrations are much higher than the ones found in the environment (Boxall et al, 2007;Gottschalk et al, 2013;Dumont et al, 2015). The literature still lacks studies focused on evaluating the cytotoxic and genotoxic effects of the exposure to environmentally relevant concentrations of NPs, except for Souza et al, (2018) and Mesak et al, (2018), who showed behavioral changes in mammals and birds due to the exposure to such concentration rates.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Research Article Zinc oxide nanoparticles at environmentally relevant concentrations cause cytotoxic and chromosomal damage to Allium cepa root cells

Sampaio¹,

Bogea²,

Neves³

et al. 2021

Genet. Mol. Res.

View full text Add to dashboard Cite

Although environmental toxicity of high concentrations of nanoparticles (NP) is well reported in the literature, information about their effects on biological systems at environmentally relevant concentrations remains scarce. We investigated whether low ZnO-NP concentrations influence the dynamics of cell division processes, cause nuclear abnormalities and induce changes in the genomic DNA using Allium cepa root cells. Healthy A. cepa bulbs were exposed to environmentally relevant concentrations of ZnO-NP for 48 hours under four different environmental conditions, namely: optimistic, median, pessimistic and known toxic. Mitotic index (MI), chromosomal abnormalities (CAs) and genomic stability based on DNA markers were estimated. ZnO-NPs induced significant changes in MI and CAs, with clear dose-response effects, even at very low concentrations and short exposure times. This outcome is clear evidence of negative effects. In addition, we evidenced instability in the repair mechanism of DNA mutated due to low concentrations of ZnO NPs based on RAPD-PCR ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 20 (1): gmr18690 L.L.G. Sampaio et al. 2results. Therefore, even short-term exposure of eukaryotic cells to low concentrations of ZnO-NP can damage cells and, consequently, negatively affect their biological functioning.

show abstract

Section: Bioaccumulation Analysissupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Research Article Zinc oxide nanoparticles at environmentally relevant concentrations cause cytotoxic and chromosomal damage to Allium cepa root cells

Sampaio¹,

Bogea²,

Neves³

et al. 2021

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…In this process, NPs interact with the organisms and are absorbed and enriched, directly or indirectly threatening the ecosystem and human health [ 13 , 14 ]. Many studies have been reported on the toxicity of NPs to bacteria, algae, plants, invertebrates, vertebrates, mammalian cells and mammals [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ], and these studies also confirm that NPs have potential environmental hazards. Although there are many reports on the effects of nanomaterials on single species of organisms, the research on nano ecotoxicology is still in its infancy [ 29 ].…”

Section: Introductionsupporting

confidence: 52%

The Widespread Use of Nanomaterials: The Effects on the Function and Diversity of Environmental Microbial Communities

Sun

et al. 2022

Microorganisms

View full text Add to dashboard Cite

In recent years, as an emerging material, nanomaterials have rapidly expanded from laboratories to large-scale industrial productions. Along with people’s productive activities, these nanomaterials can enter the natural environment of soil, water and atmosphere through various ways. At present, a large number of reports have proved that nanomaterials have certain toxic effects on bacteria, algae, plants, invertebrates, mammalian cell lines and mammals in these environments, but people still know little about the ecotoxicology of nanomaterials. Most relevant studies focus on the responses of model strains to nanomaterials in pure culture conditions, but these results do not fully represent the response of microbial communities to nanomaterials in natural environments. Over the years, the effect of nanomaterials infiltrated into the natural environment on the microbial communities has become a popular topic in the field of nano-ecological environment research. It was found that under different environmental conditions, nanomaterials have various effects on the microbial communities. The medium; the coexisting pollutants in the environment and the structure, particle size and surface modification of nanomaterials may cause changes in the structure and function of microbial communities. This paper systematically summarizes the impacts of different nanomaterials on microbial communities in various environments, which can provide a reference for us to evaluate the impacts of nanomaterials released into the environment on the microecology and has certain guiding significance for strengthening the emission control of nanomaterials pollutants.

show abstract

“…For instance, Tell et al confirmed that the extent of fluorescent microsphere deposition in primary bronchi, secondary bronchi, and abdominal air sacs increases with exposure time . Inhaled NPs such as ZnO may affect the antipredatory defensive behavior of birds . However, the risk assessment of airborne FPs in birds is challenging because (i) it is unclear whether inhaled NPs cross the air–blood barrier; (ii) the key properties dictating the behaviors of NPs in the lungs are unknown; and (iii) there is a lack of a predictive model to assess the lung penetration of NPs.…”

Section: Introductionmentioning

confidence: 99%

“…30 behavior of birds. 31 However, the risk assessment of airborne FPs in birds is challenging because (i) it is unclear whether inhaled NPs cross the air−blood barrier; (ii) the key properties dictating the behaviors of NPs in the lungs are unknown; and (iii) there is a lack of a predictive model to assess the lung penetration of NPs.…”

Section: ■ Introductionmentioning

confidence: 99%

Using Chicken Embryos to Identify the Key Determinants of Nanoparticles for the Crossing of Air–Blood Barriers

Wang

et al. 2023

Anal. Chem.

View full text Add to dashboard Cite

Fine particulates (FPs) are a major class of airborne pollutants. In mammals, FPs may reach the alveoli through the respiratory system, cross the air−blood barrier, spread into other organs, and induce hazardous effects. Although birds have much higher respiratory risks to FPs than mammals, the biological fate of inhaled FPs in birds has rarely been explored. Herein, we attempted to disclose the key properties that dictate the lung penetration of nanoparticles (NPs) by visualizing a library of 27 fluorescent nanoparticles (FNPs) in chicken embryos. The FNP library was prepared by combinational chemistry to tune their compositions, morphologies, sizes, and surface charges. These NPs were injected into the lungs of chicken embryos for dynamic imaging of their distributions by IVIS Spectrum. FNPs with diameters <16 nm could cross the air−blood barrier in 20 min, spread into the blood, and accumulate in the yolk sac. In contrast, large FNPs (>30 nm) were mainly retained in the lungs and rarely detected in other tissues/organs. In addition to size, surface charge was the secondary determinant for NPs to cross the air−blood barrier. Compared to cationic and anionic particles, neutrally charged FNPs showed the fastest lung penetration. A predictive model was therefore developed to rank the lung penetration capability of FNPs by in silico analysis. The in silico predictions could be well validated in chicks by oropharyngeal exposure to six FNPs. Overall, our study discovered the key properties of NPs that are responsible for their lung penetration and established a predictive model that will greatly facilitate respiratory risk assessments of nanoproducts.

show abstract

The effects of predicted environmentally relevant concentrations of ZnO nanoparticles on the behavior of Gallus gallus domesticus (Phasianidae) chicks

Cited by 19 publications

References 41 publications

Research Article Zinc oxide nanoparticles at environmentally relevant concentrations cause cytotoxic and chromosomal damage to <i>Allium</i> <i>cepa</i> root cells

Research Article Zinc oxide nanoparticles at environmentally relevant concentrations cause cytotoxic and chromosomal damage to <i>Allium</i> <i>cepa</i> root cells

The Widespread Use of Nanomaterials: The Effects on the Function and Diversity of Environmental Microbial Communities

Using Chicken Embryos to Identify the Key Determinants of Nanoparticles for the Crossing of Air–Blood Barriers

Contact Info

Product

Resources

About