The effects of pre- and post-exercise consumption of multi-ingredient performance supplements on cardiovascular health and body fat in trained men after six weeks of resistance training: a stratified, randomized, double-blind study

Ormsbee, Michael J.; Thomas, D. David; Mandler, W. Kyle; Ward, Emery; Kinsey, Amber W.; Scheett, Timothy P.; Hooshmand, Shirin; Simonavice, Emily; Kim, Jeong‐Su

doi:10.1186/1743-7075-10-39

Cited by 11 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, when comparing pre−post intervention results for each way of measuring hypertrophy, both groups present significant increases for FFM (untrained: 1. 54 Performing a more detailed analysis of the training status on FFM, we found that the categories sedentary/untrained and physically active but no experience in RT, have higher and more significant values than the moderately trained (RT up to 1 year/intermediate, RT experience up to 2 years /intermediate, and RT experience up to 3 years/intermediate). Additionally, the highest values achieved are those obtained by the more experienced subjects, RT experience of 4 years or more/advanced (see Figure 4).…”

Section: Subgroup Analysismentioning

confidence: 78%

A Systematic Review with Meta-Analysis of the Effect of Resistance Training on Whole-Body Muscle Growth in Healthy Adult Males

Benito

Cupeiro

Ramos-Campo

et al. 2020

IJERPH

View full text Add to dashboard Cite

We performed a systematic review and meta-analysis to study all published clinical trial interventions, determined the magnitude of whole-body hypertrophy in humans (healthy males) and observed the individual responsibility of each variable in muscle growth after resistance training (RT). Searches were conducted in PubMed, Web of Science and the Cochrane Library from database inception until 10 May 2018 for original articles assessing the effects of RT on muscle size after interventions of more than 2 weeks of duration. Specifically, we obtain the variables fat-free mass (FMM), lean muscle mass (LMM) and skeletal muscle mass (SMM). The effects on outcomes were expressed as mean differences (MD) and a random-effects meta-analysis and meta-regressions determined covariates (age, weight, height, durations in weeks…) to explore the moderate effect related to the participants and characteristics of training. One hundred and eleven studies (158 groups, 1927 participants) reported on the effects of RT for muscle mass. RT significantly increased muscle mass (FFM+LMM+SMM; Δ1.53 kg; 95% CI [1.30, 1.76], p < 0.001; I2 = 0%, p = 1.00). Considering the overall effects of the meta-regression, and taking into account the participants’ characteristics, none of the studied covariates explained any effect on changes in muscle mass. Regarding the training characteristics, the only significant variable that explained the variance of the hypertrophy was the sets per workout, showing a significant negative interaction (MD; estimate: 1.85, 95% CI [1.45, 2.25], p < 0.001; moderator: -0.03 95% CI [−0.05, −0.001] p = 0.04). In conclusion, RT has a significant effect on the improvement of hypertrophy (~1.5 kg). The excessive sets per workout affects negatively the muscle mass gain.

show abstract

Section: Subgroup Analysismentioning

confidence: 78%

A Systematic Review with Meta-Analysis of the Effect of Resistance Training on Whole-Body Muscle Growth in Healthy Adult Males

Benito

Cupeiro

Ramos-Campo

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Ad libitum on off days (post). 6 weeks of periodized resistance training (3 sessions/week) DEXA, POMS 3 ↑ FFM ( d = 0.22) ↔ FM ↔ POMS [ 65 ] Kedia et al 2014 43 resistance trained males and females Double-blind resistance training study using comparator control Prop. Blend 1: (4580 mg) Creatine Betaine Citrulline Dendrobium extract Caffeine *Comparator product matched for energy and caffeine content 30 min prior to exercise and with breakfast on off days.…”

Section: Chronic Effects Of Mips On Performancementioning

confidence: 99%

Multi-ingredient pre-workout supplements, safety implications, and performance outcomes: a brief review

Harty

Zabriskie

Erickson

et al. 2018

Journal of the International Society of Sports Nutrition

View full text Add to dashboard Cite

In recent years, a new class of dietary supplements called multi-ingredient pre-workout supplements (MIPS) has increased in popularity. These supplements are intended to be taken prior to exercise and typically contain a blend of ingredients such as caffeine, creatine, beta-alanine, amino acids, and nitric oxide agents, the combination of which may elicit a synergistic effect on acute exercise performance and subsequent training adaptations compared to single ingredients alone. Therefore, the purpose of this article was to review the theoretical rationale and available scientific evidence assessing the potential ergogenic value of acute and chronic ingestion of MIPS, to address potential safety concerns surrounding MIPS supplementation, and to highlight potential areas for future research. Though direct comparisons between formulations of MIPS or between a MIPS and a single ingredient are challenging and often impossible due to the widespread use of “proprietary blends” that do not disclose specific amounts of ingredients in a given formulation, a substantial body of evidence suggests that the acute pre-exercise consumption of MIPS may positively influence muscular endurance and subjective mood, though mixed results have been reported regarding the acute effect of MIPS on force and power production. The chronic consumption of MIPS in conjunction with a periodized resistance training program appears to augment beneficial changes in body composition through increased lean mass accretion. However, the impact of long-term MIPS supplementation on force production, muscular endurance, aerobic performance, and subjective measures is less clear. MIPS ingestion appears to be relatively safe, though most studies that have assessed the safety of MIPS are relatively short (less than eight weeks) and thus more information is needed regarding the safety of long-term supplementation. As with any dietary supplement, the use of MIPS carries implications for the athlete, as many formulations may intentionally contain banned substances as ingredients or unintentionally as contaminants. We suggest that athletes thoroughly investigate the ingredients present in a given MIPS prior to consumption. In conclusion, it appears that multi-ingredient pre-workout supplements have promise as an ergogenic aid for active individuals, though further information is required regarding long-term efficacy and safety in a wider variety of populations.

show abstract

“…Some studies have documented improvements in subjective feelings of energy and focus [ 91 , 92 ], while Gonzalez et al [ 98 ] did not. When taken chronically for a period of 4 to 8 weeks, multi-ingredient pre-workout supplements have been shown to increase measures of strength [ 93 , 94 , 97 ], power output [ 96 ], and lean mass [ 93 – 95 ]. In contrast, Outlaw et al [ 99 ] found no significant benefit for body composition, strength, or power output with ingestion of a multi-ingredient supplement versus placebo.…”

Section: Introductionmentioning

confidence: 99%

International society of sports nutrition position stand: Beta-Alanine

Trexler¹,

Smith‐Ryan²,

Stout

et al. 2015

Journal of the International Society of Sports Nutrition

194

214

View full text Add to dashboard Cite

Position statementThe International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of beta-alanine supplementation. Based on the current available literature, the conclusions of the ISSN are as follows: 1) Four weeks of beta-alanine supplementation (4–6 g daily) significantly augments muscle carnosine concentrations, thereby acting as an intracellular pH buffer; 2) Beta-alanine supplementation currently appears to be safe in healthy populations at recommended doses; 3) The only reported side effect is paraesthesia (tingling), but studies indicate this can be attenuated by using divided lower doses (1.6 g) or using a sustained-release formula; 4) Daily supplementation with 4 to 6 g of beta-alanine for at least 2 to 4 weeks has been shown to improve exercise performance, with more pronounced effects in open end-point tasks/time trials lasting 1 to 4 min in duration; 5) Beta-alanine attenuates neuromuscular fatigue, particularly in older subjects, and preliminary evidence indicates that beta-alanine may improve tactical performance; 6) Combining beta-alanine with other single or multi-ingredient supplements may be advantageous when supplementation of beta-alanine is high enough (4–6 g daily) and long enough (minimum 4 weeks); 7) More research is needed to determine the effects of beta-alanine on strength, endurance performance beyond 25 min in duration, and other health-related benefits associated with carnosine.

show abstract

The effects of pre- and post-exercise consumption of multi-ingredient performance supplements on cardiovascular health and body fat in trained men after six weeks of resistance training: a stratified, randomized, double-blind study

Cited by 11 publications

References 30 publications

A Systematic Review with Meta-Analysis of the Effect of Resistance Training on Whole-Body Muscle Growth in Healthy Adult Males

A Systematic Review with Meta-Analysis of the Effect of Resistance Training on Whole-Body Muscle Growth in Healthy Adult Males

Multi-ingredient pre-workout supplements, safety implications, and performance outcomes: a brief review

International society of sports nutrition position stand: Beta-Alanine

Contact Info

Product

Resources

About