The Effects of Polysulfated Glycosaminoglycan (Adeqtiail®) on Activated Partial Thromboplastin Time, Prothrombin Time, Complete Blood Count, Biochemical Profile and Urinalysis in Cats

Abstract

SummaryThe effects of a single intramuscular administration of polysulfated glycosaminoglycan (PSGAG, Adequan®a) on activated partial thromboplastin time (APTT), prothrombin time (PT), complete blood count (CBC), biochemical profile and urinalysis were determined in six adult cats. An injection of 5 mg/kg of PSGAG was given to three of the cats, and an injection of 25 mg/kg was given to the other three cats. Following a seven-day crossover interval, the doses were reversed. Serial blood and urine samples were collected over a 48-hour period after each injection. Administration of PSGAG resulted in a transient, dose-dependent increase of APTT and PT. Prolonged bleeding from the venipuncture sites in the 25 mg/kg group was observed. Some of the CBC, biochemical profile, and urinalysis values changed following treatment, but clinically significant adverse reactions were not noticed.Polysulfated glycosaminoglycan (Adequan®) is a heparin analogue with chondroprotective and anticoagulant properties. A single intramuscular injection of 5 mg/kg and 25 mg/kg of polysulfated glycosaminoglycan in six healthy adult cats resulted in a transient, dose-dependent increase of activated partial thromboplastin time and prothrombin time. Minor changes were seen on complete blood count, biochemical profile and urinalysis.