The effects of plasma chromium on lipid profile, glucose metabolism and cardiovascular risk in type 2 diabetes mellitus. A case - control study

Abstract

BackgroundThe study was aimed at determining the effect of plasma chromium concentration on the metabolism of glucose, and lipids and their subsequent cardiovascular risk in patients with type 2 diabetes in the Bolgatanga district of Ghana.Material and methodsFasting blood glucose and lipids profile were determined by enzymatic assay using the BT 5000® Random Access Chemistry Analyzer. Fasting serum insulin and High sensitive C-reactive protein were determined by ELISA, a solid phase direct sandwich immunoassay method. HOMA-IR, which is based on fasting blood sample for insulin and glucose concentrations measured in a single blood sample, was used to calculate insulin resistance. Plasma chromium was measured using an atomic Absorption Spectrometer.ResultsPatientswith diabeteshad significantly (p<0.0001) increased LDL, TC, TG, VLDL, insulin, CRP and HOMAIR and a significantly reduced plasma chromium (p<0.0001) (0.53± 0.02μg/l and 0.11±0.01μg/l control and case respectively). Low Cr (p ≤0.001) was associated with high blood pressure, obesity and lipid dysregulation. Plasma Cr significantly correlated negatively with blood pressure and LDL.ConclusionLower plasma Cr level was associated with hyperglycaemia, hyperinsulinemia, hypertension, insulin resistance and high inflammation marker HsCRP.

THE EFFECTS OF CHROMIUM MICROADDITIVE IN DIFFERENT DIETS FOR LAYING HENS (Gallus gallus L.) ON THE INTESTINAL DIGESTION AND CERTAIN BIOCHEMICAL BLOOD PARAMETERS

“…Наши экспериментальные данные также согласуются с результатами исследований (1, 2), в которых показано, что хром регулирует гомеостаз глюкозы в крови, активируя рецепторы инсулина и тем самым, как уже отмечалось, модулирует сигнальную трансдукцию и повышает чувствительность к инсулину (29,30). Что касается липидного обмена, то мы, в отличие от А.А.…”

Dietary Patterns and Health Outcomes among African American Maintenance Hemodialysis Patients

“…Low Zn status has been associated with lipid peroxidation and inflammation in those with CKD [42]. Lower Cr levels have been associated with malnutrition in HD patients [43], and with inflammation, increased cardiovascular risk, and lower levels of HDL in non-CKD populations [44,45]. Lower concentrations of Se have been associated with higher rates of hospitalization and death among HD patients [46].…”

КИШЕЧНОЕ ПИЩЕВАРЕНИЕ И БИОХИМИЯ КРОВИ У КУР-НЕСУШЕК (Gallus gallus L.) ПРИ ВВЕДЕНИИ В РАЦИОНЫ МИКРОДОБАВКИ ХРОМА

“…Наши экспериментальные данные также согласуются с результатами исследований (1,2), в которых показано, что хром регулирует гомеостаз глюкозы в крови, активируя рецепторы инсулина и тем самым, как уже отмечалось, модулирует сигнальную трансдукцию и повышает чувствительность к инсулину (29,30). Что касается липидного обмена, то мы, в отличие от А.А.…”