The Effects of Physical Exercise on Saliva Composition: A Comprehensive Review

Ntovas, Panagiotis; Loumprinis, Nikolaos; Maniatakos, Panagiotis; Margaritidi, Loukia; Rahiotis, Christos

doi:10.3390/dj10010007

Cited by 18 publications

(12 citation statements)

References 130 publications

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“…[16–17], metabolomic markers [18] and so on. However, as a complex biofluid, saliva contains a large number of electrolytes, high‐abundant proteins, enzymes, lipids, and other molecules which present a significant obstacle to salivary biopsy [19]. To overcome the challenges of liquid biopsy using clinical body fluids as the source, a new strategy has emerged based on the profiling of extracellular vesicles (EVs) isolated from body fluids such as saliva, urine, tears, and plasma [20–22].…”

Section: Introductionmentioning

confidence: 99%

Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes

et al. 2023

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Circulating extracellular vesicles (EVs) have emerged as an appealing source for surrogates to evaluate the disease status. Herein, we present a novel proteomic strategy to identify proteins and phosphoproteins from salivary EVs to distinguish oral squamous cell carcinoma (OSCC) patients from healthy individuals and explore the feasibility to evaluate therapeutical outcomes. Bi‐functionalized magnetic beads (BiMBs) with Ti (IV) ions and a lipid analog, 1,2‐Distearoyl‐3‐sn‐glycerophosphoethanolamine (DSPE) are developed to efficiently isolate EVs from small volume of saliva. In the discovery stage, label‐free proteomics and phosphoproteomics quantification showed 315 upregulated proteins and 132 upregulated phosphoproteins in OSCC patients among more than 2500 EV proteins and 1000 EV phosphoproteins, respectively. We further applied targeted proteomics by coupling parallel reaction monitoring with parallel accumulation‐serial fragmentation (prm‐PASEF) to measure panels of proteins and phosphoproteins from salivary EVs collected before and after surgical resection. A panel of three total proteins and three phosphoproteins, most of which have previously been associated with OSCC and other cancer types, show sensitive response to the therapy in individual patients. Our study presents a novel strategy to the discovery of effective biomarkers for non‐invasive assessment of OSCC surgical outcomes with small amount of saliva.

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Section: Introductionmentioning

confidence: 99%

Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes

et al. 2023

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“…Athletes regularly use sports, energy drinks, and carbohydrate‐rich nutrients in drinks or gels during training and competition. At the same time, dehydration and stress caused during sports activity aggravate the effect of carbohydrates and acidic components on the dental hard tissues, reducing the protective effect of saliva 7 …”

Section: Introductionmentioning

confidence: 99%

“…dehydration and stress caused during sports activity aggravate the effect of carbohydrates and acidic components on the dental hard tissues, reducing the protective effect of saliva. 7 Moreover, during their activity, athletes have an increased risk of injuries to the head and mouth, especially in contact sports and martial arts. 8 Therefore, a key component in preventing these conditions is identifying individual risk factors, pertinent information, and guidance of athletes by the dentist.…”

mentioning

confidence: 99%

A suggested universal protocol for dental examination in sports

Stamos,

Engels‐Deutsch,

Cantamessa

et al. 2023

Dental Traumatology

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The athletes of any sport and level submit their bodies to constant exercise. Any given pathology can increase the risk of injury, illness, or even reduced performance. The medical examination is valuable in diagnosing existing health problems and preventing medical issues that might compromise the athlete's overall health when exercising. The stomatognathic system is not an exemption, as oral pathologies, including dental caries and periodontal diseases, are found in high incidence in sports. The need for accurate and detailed dental examination in sports leaded dentists from the European Association for Sports Dentistry and the Academy for Sports Dentistry to elaborate a universal dental examination in sports protocol that can record the overall oral health of the athlete, including the teeth, periodontium, and musculoskeletal screening, for all athletes. The outcome of this stomatognathic examination allows sports physicians and professionals other than dentists to have a complete image of the individual oral health condition of any given athlete, and it allows the dentists to efficiently screen and prevent pathologies, as well as to advise on the eligibility to practice sports from the oral health perspective.

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“…About 93% of major salivary glands have a large role in salivary secretion compared to minor salivary glands. When saliva comes into direct contact with the oral cavity, it will mix with cervical gingival fluid, mucus from the pharynx and nasal cavity, and food debris which is referred to as whole saliva [4]. pH (Potential of Hydrogen) is a unit used to measure the degree of acidity in the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

Effect of consuming original yogurt on changes in saliva pH in the oral cavity

Kristanto¹,

Putri²,

Sumaryono³

et al. 2023

World J. Adv. Res. Rev.

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Background: Dental caries occur due to a dynamic demineralization process that happens when calcium and phosphate ions are dissolved and carbohydrates are fermented by microorganisms in the mouth, leading to a decrease in saliva pH. Saliva production occurs as a response to stimuli such as tasting and chewing food. Saliva contains oral cavity bacteria, cervical gingival fluid, and leftover food, known as whole saliva. Normally, saliva pH ranges from 6.8-7.2 and can decrease if someone consumes foods and drinks containing sucrose. One way to reduce the risk of dental caries is by consuming original yogurt. Yogurt contains probiotic bacteria, namely Lactobacillus bulgaricus and Streptococcus thermophilus, which act as inhibitors of cariogenic bacteria growth. The calcium content in yogurt helps in the tooth remineralization process. Purpose: This study aims to determine the effect of consuming original yogurt on changes in saliva pH in the oral cavity. Methods: This research is pre-experimental with pretest and posttest design. The research sample consisted of 30 dental students from the Faculty of Dentistry, Institute of Health Sciences Bhakti Wiyata Kediri in 2019, 2020, 2021 and 2022, who met the sample criteria. Results: Data were analyzed using the parametric Paired T-Test hypothesis test, with a significance value of 0.000. Conclusion: Original yogurt consumption has an impact on changes on salivary pH in the oral cavity.

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The Effects of Physical Exercise on Saliva Composition: A Comprehensive Review

Cited by 18 publications

References 130 publications

Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes

Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes

A suggested universal protocol for dental examination in sports

Effect of consuming original yogurt on changes in saliva pH in the oral cavity

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