The effects of phthalate exposure on metabolic parameters in polycystic ovary syndrome

Milankov, Andrijana; Milanović, Maja; Milošević, Nataša; Sudji, Jan; Pejaković, Slađana; Milić, Nataša; Bjelica, Artur; Stojanoska, Milica Medić

doi:10.1016/j.cca.2023.117225

Cited by 10 publications

(6 citation statements)

References 44 publications

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“…Thirdly, to investigate if these triazoles or metabolites concentrations interferes with obesity and PCOS, it will be important to determine if it exists an association between FF triazole concentration and plasma glucose and lipid. Indeed, it has been recently shown that total phthalate metabolites urine concentrations were positively associated with BMI, lipid accumulation product and significantly linked with fasting plasma glucose [41] . In a case-control study, Zhan et al showed that environmental exposure to bisphenol analogs was associated with increased odds of PCOS and this association was stronger among obese and overweight women [72] .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, obesity influences androgen levels [21] , [54] , [76] . Pollutants such as phthalates have been already shown to be positively correlated with BMI, leptin concentration in blood, lipids concentration and visceral adipose index in women [41] Our hypothesis is that ovarian cells from PCOS women with or without obesity could be more sensitive to Epox and Tb than those from normal-weight women and could contribute to explain some ovarian disorders.…”

Section: Introductionmentioning

confidence: 91%

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The epoxiconazole and tebuconazole fungicides impair granulosa cells functions partly through the aryl hydrocarbon receptor (AHR) signalling with contrasted effects in obese, normo-weight and polycystic ovarian syndrome (PCOS) patients

Serra,

Estienne,

Bongrani

et al. 2024

Toxicology Reports

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

The epoxiconazole and tebuconazole fungicides impair granulosa cells functions partly through the aryl hydrocarbon receptor (AHR) signalling with contrasted effects in obese, normo-weight and polycystic ovarian syndrome (PCOS) patients

Serra,

Estienne,

Bongrani

et al. 2024

Toxicology Reports

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“…Most available cross-sectional studies have demonstrated a direct association between one or more of the numerous measured phthalate metabolites and measures of adiposity [ 78 , 203 , 204 , 208 , 212 , 214 ]. Supportive evidence has also been provided by prospective observational studies, which have generally demonstrated associations between phthalate urine [ 192 , 202 , 205 , 209 ] or serum [ 213 ] concentrations and prospective weight or fat mass over follow-up durations as prolonged as approximately 10 years.…”

Section: Evidence From Human Studies Linking Bpa and Phthalates To Ob...mentioning

confidence: 99%

The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies

Dalamaga,

Kounatidis,

Tsilingiris

et al. 2024

IJMS

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Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of physical exercise, recent data have highlighted a possible association between endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates and their analogs, and obesity. EDCs represent a heterogeneous group of chemicals that may influence the hormonal regulation of body mass and adipose tissue morphology. Based on the available data from mechanistic, animal and epidemiological studies including meta-analyses, the weight of evidence points towards the contribution of EDCs to the development of obesity, associated disorders and obesity-related adipose tissue dysfunction by (1) impacting adipogenesis; (2) modulating epigenetic pathways during development, enhancing susceptibility to obesity; (3) influencing neuroendocrine signals responsible for appetite and satiety; (4) promoting a proinflammatory milieu in adipose tissue and inducing a state of chronic subclinical inflammation; (5) dysregulating gut microbiome and immune homeostasis; and (6) inducing dysfunction in thermogenic adipose tissue. Critical periods of exposure to obesogenic EDCs are the prenatal, neonatal, pubertal and reproductive periods. Interestingly, EDCs even at low doses may promote epigenetic transgenerational inheritance of adult obesity in subsequent generations. The aim of this review is to summarize the available evidence on the role of obesogenic EDCs, specifically BPA and phthalate plasticizers, in the development of obesity, taking into account in vitro, animal and epidemiologic studies; discuss mechanisms linking EDCs to obesity; analyze the effects of EDCs on obesity in critical chronic periods of exposure; and present interesting perspectives, challenges and preventive measures in this research area.

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“…They also have an impact on serum lipoprotein levels in women with PCOS. The sum of phthalates in the urine correlates with LDL-C, TG, and TC to HDL-C ratio, while Mono-methyl-phthalate urine levels are associated with TC, LDL-C, TG, and TC to HDL-C ratio ( 39 ). Thus, exposure to phthalates should be avoided to minimize the degree of dyslipidemia in PCOS patients.…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field

Olejarz,

Szczepanek-Parulska,

Ruchala

2024

Front. Endocrinol.

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Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude of complications. Thus proper diagnostics, which includes identifying of secondary causes of dyslipidemia is crucial. Endocrine disorders are an important cause of secondary dyslipidemia. This paper aims to review the publications on lipoprotein alterations in endocrine disorders from the past two years and provide an overview of the recent discoveries in this dynamically developing and large field. Significant changes in lipoprotein serum concentrations are present in most endocrinological diseases and can be modified with proper treatment. Some lipoproteins have also been proposed as markers in some endocrine diseases, e.g., thyroid carcinoma. From the scope of endocrine disorders, the largest number of studies explored the lipoprotein changes in polycystic ovary syndrome and in women during the menopausal and peri-menopausal period. Even though the association of thyroid disorders with dyslipidemia is already well studied, new research has delivered some exciting findings about lipoprotein alterations in euthyroid patients with either positive antithyroid peroxidase antibodies or reduced sensitivity to thyroid hormones. The problem of the adverse metabolic profile, including dyslipidemia in hypoprolactinemia has been recognized. Moreover, this review describes other significant discoveries encompassing lipoprotein alterations in disorders of the adrenals, thyroid, parathyroid glands, pituitary, and gonads. The up-to-date knowledge of the influence of endocrine disorders and hormonal changes on serum lipoproteins is prudent as it can significantly impact therapeutic decisions.

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The effects of phthalate exposure on metabolic parameters in polycystic ovary syndrome

Cited by 10 publications

References 44 publications

The epoxiconazole and tebuconazole fungicides impair granulosa cells functions partly through the aryl hydrocarbon receptor (AHR) signalling with contrasted effects in obese, normo-weight and polycystic ovarian syndrome (PCOS) patients

The epoxiconazole and tebuconazole fungicides impair granulosa cells functions partly through the aryl hydrocarbon receptor (AHR) signalling with contrasted effects in obese, normo-weight and polycystic ovarian syndrome (PCOS) patients

The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies

Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field

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