The effects of photodynamic therapy on conjunctival in situ squamous cell carcinoma - a review of the histopathology

Sears, Katharine; Rundle, P R; Mudhar, Hardeep Singh; Rennie, I G

doi:10.1136/bjo.2006.112326

Cited by 6 publications

(3 citation statements)

References 4 publications

(5 reference statements)

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“…Following PDT, using verteporfin, a complete clinical CIN regression, supported with angiographic evidence, has been reported at 1 month, without any recurrence for a mean follow-up of 8.6 months (Barbazetto et al, 2004). Likewise, histopathological evidence showing tumor regression following treatment with PDT in a patient with in situ CIN has been reported (Sears et al, 2008).…”

Section: Other Treatment Possibilitiesmentioning

confidence: 84%

Intraepithelial Neoplasia

2009

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She attended medical school in India (Meerut, UP) and graduated in 2001. She then specialized in Pathology at King Georges' Medical University, Lucknow (UP), receiving her postgraduate medical degree (MD) in 2007. As a medical student she received various recognitions in academic circles. For more than three years, she has been actively engaged in research at the National University of Singapore. Her areas of research include identifying biomarkers in patients at high risk of gastric cancer, prognostic biomarkers in hepatocellular carcinoma and cervical carcinoma and identifying the origin of Barrett's Oesophagus. She is also involved in research projects involving confocal laser endomicroscopy of the gastrointestinal tract and Laser Capture Microdissection, and has been an author and co-author in various papers on topics within her research interest. ContentsPreface XIII Part Intraepithelial Neoplasia of Oral Cavity 1

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Section: Other Treatment Possibilitiesmentioning

confidence: 84%

Intraepithelial Neoplasia

2009

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“…29,30 Conjunctival tumours The preliminary results suggest that PDT may be an alternative treatment for ocular surface squamous neoplasia, particularly with diffuse presentation. [31][32][33] Retinal tumours PDT with verteporfin causes fewer side effects as it offers site-specific tumour destruction while sparing surrounding structures. 26 Moreover, red wavelength has deeper penetration into the haemangioma than laser photocoagulation.…”

Section: Indications and Resultsmentioning

confidence: 99%

Ocular phototherapy

Singh

2012

Eye

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Phototherapy can be translated to mean 'light or radiant energy-induced treatment.' Lasers have become the exclusive source of light or radiant energy for all applications of phototherapy. Depending on the wavelength, intensity, and duration of exposure, tissues can either absorb the energy (photocoagulation, thermotherapy, and photodynamic therapy (PDT)) or undergo ionization (photodisruption). For phototherapy to be effective, the energy has to be absorbed by tissues or more specifically by naturally occurring pigment (xanthophyll, haemoglobin, and melanin) within them. In tissues or tumours that lack natural pigment, dyes (verteporphin, Visudyne) with narrow absorption spectrum can be injected intravenously that act as focal absorbent of laser energy after they have preferentially localized within the tumour. Ocular phototherapy has broad applications in treatment of ocular tumours. Laser photocoagulation, thermotherapy, and PDT can be delivered with low rates of complications and with ease in the outpatient setting. Review of the current literature suggests excellent results when these treatments are applied for benign tumours, particularly for vascular tumours such as circumscribed choroidal haemangioma. For primary malignant tumours, such as choroidal melanoma, thermotherapy, and PDT do not offer local tumour control rates that are equivalent or higher than those achieved with plaque or proton radiation therapy. However, for secondary malignant tumours (choroidal metastases), thermotherapy and PDT can be applied as a palliative treatment. Greater experience is necessary to fully comprehend risks, comparative benefits, and complication of ocular phototherapy of ocular tumours.

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“…Likewise, histopathological evidence showing tumor regression following treatment with PDT in a patient with in situ CIN has been reported (Sears et al, 2008). The book "Intraepithelial neoplasia" is till date the most comprehensive book dedicated entirely to preinvasive lesions of the human body.…”

Section: Other Treatment Possibilitiesmentioning

confidence: 99%