The effects of photobiomodulation therapy on Staphylococcus aureus infected surgical wounds in diabetic rats. A microbiological, histopathological, and biomechanical study

Ranjbar, Reza; Takhtfooladi, Mohammad Ashrafzadeh

doi:10.1590/s0102-865020160080000001

Cited by 13 publications

(10 citation statements)

References 39 publications

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“…PBM also resulted in significantly shorter wound length (on days 14 and 21), and a significant increase in the number of macrophages, new blood vessels, fibroblasts, and collagen deposition. The breaking strength of the scars was also significantly increased in PBM treated rats [67]. This study has shown the potential of utilizing PBM in the treatment of infected diabetic wounds.…”

Section: Photobiomodulation For Diabetic Wound Healingsupporting

confidence: 52%

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Healing Effects of Photobiomodulation on Diabetic Wounds

Houreld

2019

Applied Sciences

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Diabetic patients frequently develop chronic ulcers of the lower extremities, which are a frequent cause for hospitalization and amputation, placing strain on patients, their families, and healthcare systems. Present therapies remain a challenge, with high recurrence rates. Photobiomodulation (PBM), which is the non-invasive application of light at specific wavelengths, has been shown to speed up healing of chronic wounds, including diabetic foot ulcers (DFUs). PBM produces photophysical and photochemical changes within cells without eliciting thermal damage. It has been shown to promote tissue regeneration and speed up wound repair by reducing inflammation and oxidative stress, accelerating cell migration and proliferation, and promoting extracellular matrix production and release of essential growth factors. The shortage of rigorous, well-designed clinical trials makes it challenging to assess the scientific impact of PBM on DFUs, and lack of understanding of the underlying mechanisms also hinders the conventional use of this therapy. This review gives a glimpse into diabetic wound healing and PBM, and the effects of PBM on diabetic wound healing.

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Section: Photobiomodulation For Diabetic Wound Healingsupporting

confidence: 52%

“…A study on the effect of PBM on S. aureus infected wounds in diabetic rats was conducted by Ranjbar and colleagues [67]. Streptozotocin-induced male Wistar rats received 4 cm full-thickness linear incisions on the dorsal midline which were contaminated with 5 × 10 7 CFU/mL of S. aureus.…”

Section: Photobiomodulation For Diabetic Wound Healingmentioning

confidence: 99%

Healing Effects of Photobiomodulation on Diabetic Wounds

Houreld

2019

Applied Sciences

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“…E. coli ( 35 - 38 ), K. pneumonia ( 39 - 41 ), P. aeruginosa ( 42 - 43 ), Staphylococcus spp . ( 44 - 45 ), Serratia spp. ( 46 ) , and Shigella spp.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory activities of platelet-rich and platelet-poor plasma on the growth- of pathogenic bacteria

Maghsoudi¹,

Ranjbar²,

Mirjalili³

et al. 2017

Iran J Pathol

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Background: The utility and efficacy of novel materials in tissue regeneration and antimicrobial therapy are contingent upon the employment of either blood derivatives rich in platelets or platelet-poor-plasma (PPP). This effect is largely mediated by the increased or decreased concentration of platelets in the plasma. The current study aimed to analyze and evaluate the impact of platelet-rich (PRP) or PPP on inhibiting the growth of human pathogenic bacteria and compare their effects with those of chloramphenicol and penicillin. Methods: In the current comparative study, PRP–1 was generated using 1-step blood centrifugation method; whereas, for PRP–2 and PPP the 2-step centrifugation protocol was used. The antimicrobial activity of PRP–1, 2, and PPP were tested on Staphylococcus aureus , Escherichia coli , Klebsiella pneumonia , Pseudomonas aeruginosa , Streptococcus agalactiae , Staphylococcus epidermidis , Shigella sp. and Serratia sp. Well diffusion and serial micro-dilution methods were used for this purpose. Chloramphenicol and penicillin susceptibility were tested using the disk diffusion method. Results: While whole blood (WB) and PPP had no discernible impact on the growth parameters of any of the bacteria tested in the current study, PRP-1 reduced the growth rate of a few selected strains. In addition, while PRP-2 clearly inhibited the growth of Shigella sp. , E. coli, S. aureus , S. agalactiae, and S. epidermidis , it had no impact on the growth of K. pneumoniae , P. aeruginosa, and Serratia sp Conclusion: It can be claimed that there is a strong correlation between the concentration of platelets and the antibacterial activity of PRP.

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“…The LumiHeal Protocol has been applied over the last 3 months in 8 patients with complicated treatment-resistant infected wounds. The improvement in the wounds is documented by photographic evidence [15][16][17][18][19][20].…”

Section: Lumihealmentioning

confidence: 99%

From Tissue Repair to Tissue Regeneration

Emanuele¹,

Giada²,

Alessio³

et al. 2019

Wound Healing - Current Perspectives

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In Regeneration 3.0, the priority is to combine the anti-inflammatory activity of the nine proteins acting as growth factors in the bovine colostrum, the homeostatic, angiogenic and reorganizational activities of the matrix, the modulation of collagen synthesis and the remodeling of the epithelium. The choice of bovine colostrum and its associated properties was the basis for the design of devices that could also offer those properties: barrier action, anti-inflammatory action and pain reduction, reduction and absorption of exudates, combating of bacterial and fungal proliferation, antioxidant action and hydration and protection against skin diseases and dermatosis. We now know the key players in the wound healing process and we have new molecules available to act on them, but the future must necessarily lie in the transfer of molecules and information between the endothelium, ECM and cell membrane, which can be directed toward tissue regeneration if the resident stem cells have the chance of communicating and interacting with new therapeutic models, all this without forgetting that the human being is at the center of research and scientific evolution.

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The effects of photobiomodulation therapy on Staphylococcus aureus infected surgical wounds in diabetic rats. A microbiological, histopathological, and biomechanical study

Cited by 13 publications

References 39 publications

Healing Effects of Photobiomodulation on Diabetic Wounds

Healing Effects of Photobiomodulation on Diabetic Wounds

Inhibitory activities of platelet-rich and platelet-poor plasma on the growth- of pathogenic bacteria

From Tissue Repair to Tissue Regeneration

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