The Effects of Photobiomodulation on Bone Defect Repairing in a Diabetic Rat Model

Lee, Ji-Hua; Kong, Su-Chii; Chen, Chia-Hsin; Lin, Ying‐Chun; Lee, Kun-Tsung; Wang, Yan‐Hsiung

doi:10.3390/ijms222011026

Cited by 6 publications

(6 citation statements)

References 53 publications

(54 reference statements)

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“…During wound treatment, filling a deep wound with gauze and then covering with dressing is a common clinical treatment [35]. The purpose is to overcome the limitation of the dressing that cannot touch the depth of the wounds so that the exudate can be better absorbed.…”

Section: Discussionmentioning

confidence: 99%

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A Multifunctional Polyethylene Glycol/Triethoxysilane-Modified Polyurethane Foam Dressing with High Absorbency and Antiadhesion Properties Promotes Diabetic Wound Healing

Chen,

Chen

et al. 2023

IJMS

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The delayed healing of chronic wounds, such as diabetic foot ulcers (DFUs), is a clinical problem. Few dressings can promote wound healing by satisfying the demands of chronic wound exudate management and tissue granulation. Therefore, the aim of this study was to prepare a high-absorption polyurethane (PU) foam dressing modified by polyethylene glycol (PEG) and triethoxysilane (APTES) to promote wound healing. PEG-modified (PUE) and PEG/APTES-modified (PUESi) dressings were prepared by self-foaming reactions. Gauze and PolyMem were used as controls. Next, Fourier transform-infrared spectroscopy, thermomechanical analyses, scanning electron microscopy and tensile strength, water absorption, anti-protein absorption, surface dryness and biocompatibility tests were performed for in vitro characterization. Wound healing effects were further investigated in nondiabetic (non-DM) and diabetes mellitus (DM) rat models. The PUE and PUESi groups exhibited better physicochemical properties than the gauze and PolyMem groups. Moreover, PUESi dressing showed better anti-adhesion properties and absorption capacity with deformation. Furthermore, the PUESi dressing shortened the inflammatory phase and enhanced collagen deposition in both the non-DM and DM animal models. To conclude, the PUESi dressing not only was fabricated with a simple and effective strategy but also enhanced wound healing via micronegative-pressure generation by its high absorption compacity with deformation.

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Section: Discussionmentioning

confidence: 99%

“…The water uptake of the PU foams was determined by soaking them in phosphatebuffered saline (PBS, pH 7.4) at 37 • C. The weight of the specimens was measured after 2, 4, 6, 8 and 10 min. Water uptake was defined as the ratio of the increase in weight compared to the initial weight [35].…”

Section: Water Absorptionmentioning

confidence: 99%

A Multifunctional Polyethylene Glycol/Triethoxysilane-Modified Polyurethane Foam Dressing with High Absorbency and Antiadhesion Properties Promotes Diabetic Wound Healing

Chen,

Chen

et al. 2023

IJMS

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“…A total of 16 studies were conducted to evaluate impact of PBM on healing of bone defect, with 15 studies conducted on preclinical models (125)(126)(127)(128)(129)(130)(131)(132)(133)(134)(135)(136)(137)(138)(139) and one study in humans (140) (Table 7). Among these studies, only one preclinical study did not report a positive impact of PBM on bone repair.…”

Section: Healing Of Bone Defectmentioning

confidence: 99%

Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization

Perrier,

Moro,

Lablanche

2024

Front. Endocrinol.

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IntroductionDiabetes is a global health concern characterized by chronic hyperglycemia resulting from insulinopenia and/or insulin resistance. The rising prevalence of diabetes and its associated complications (ulcers, periodontitis, healing of bone defect, neuropathy, retinopathy, cardiopathy and nephropathy) necessitate innovative therapeutic approaches. Photobiomodulation (PBM), involves exposing tissues and cells to low-energy light radiation, leading to biological effects, largely via mitochondrial activation.MethodsThis review evaluates preclinical and clinical studies exploring the potential of PBM in diabetes and its complications, as well all clinical trials, both planned and completed, available on ClinicalTrials database.ResultsThis review highlights the variability in PBM parameters across studies, hindering consensus on optimal protocols. Standardization of treatment parameters and rigorous clinical trials are needed to unlock PBM’s full therapeutic potential. 87 clinical trials were identified that investigated PBM in diabetes mellitus (with 5,837 patients planned to be treated with PBM). Clinical trials assessing PBM effects on diabetic neuropathy revealed pain reduction and potential quality of life improvement. Studies focusing on wound healing indicated encouraging results, with PBM enhancing angiogenesis, fibroblast proliferation, and collagen density. PBM’s impact on diabetic retinopathy remains inconclusive however, requiring further investigation. In glycemic control, PBM exhibits positive effects on metabolic parameters, including glucose tolerance and insulin resistance.ConclusionClinical studies have reported PBM-induced reductions in fasting and postprandial glycemia without an increased hypoglycemic risk. This impact of PBM may be related to its effects on the beta cells and islets in the pancreas. Notwithstanding challenges, PBM emerges as a promising adjunctive therapy for managing diabetic neuropathy, wound healing, and glycemic control. Further investigation into its impact on diabetic retinopathy and muscle recovery is warranted.

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“…PBM in diabetic models: studies in diabetic animal models with PBM therapy are relevant as diabetes is recognized risk factor for MRONJ [51]. Hyperglycemic animals had significantly less bone regeneration than controls, but with PBM, bone regeneration increased comparable to that in non-diabetic control animals [52]. Significant effects upon healing of skin wounds in diabetic rats were seen with PBM [53].…”

Section: Topical or Systemic Agents For Mronj Managementmentioning

confidence: 99%

Medication-Related Osteonecrosis of the Jaw: Successful Medical Management of Complex Maxillary Alveolus with Sinus Involvement

Epstein¹,

Arany²,

Yost³

et al. 2023

Case Rep Oncol

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Medication-related osteonecrosis of the jaw (MRONJ) in cancer patients presents a considerable challenge in management. Current management is primarily based on interventions in a limited number of cases assessing a single approach. Medical management typically is reported to include antimicrobial therapy with or without surgery. Advances in the understanding of pathogenesis have led to the investigation of additional medical interventions for early-stage necrosis. We present 3 patients with advanced-stage MRONJ of the maxilla using combined medical modalities including antimicrobial therapy, photobiomodulation therapy, pentoxifylline, vitamin E, and synthetic parathyroid hormone. All patients had a good outcome and avoided surgical intervention. We also report biological and functional imaging that may assist in more effective diagnosis and management of MRONJ. The 3 patients reported suggest that combined medical management should be considered in all cases of MRONJ (including stage III) prior to determining if surgical intervention is required. Functional imaging with a technetium bone scan or positron emission tomography scan correlated with diagnosis and confirmed resolution in patients. We present 3 challenging MRONJ patients that were effectively managed with a combined medical and nonsurgical therapy that demonstrated good clinical outcomes avoiding surgical interventions.

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The Effects of Photobiomodulation on Bone Defect Repairing in a Diabetic Rat Model

Cited by 6 publications

References 53 publications

A Multifunctional Polyethylene Glycol/Triethoxysilane-Modified Polyurethane Foam Dressing with High Absorbency and Antiadhesion Properties Promotes Diabetic Wound Healing

A Multifunctional Polyethylene Glycol/Triethoxysilane-Modified Polyurethane Foam Dressing with High Absorbency and Antiadhesion Properties Promotes Diabetic Wound Healing

Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization

Medication-Related Osteonecrosis of the Jaw: Successful Medical Management of Complex Maxillary Alveolus with Sinus Involvement

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