THE EFFECTS OF PEPSIN AND TRYPSIN ON THE INDUCTIVE ABILITY OF PENTOSE NUCLEOPROTEIN FROM GUINEA PIG LIVER<sup>1)</sup>

Hayashp, Yujiro

doi:10.1111/j.1440-169x.1958.tb00146.x

Cited by 28 publications

(4 citation statements)

References 15 publications

(6 reference statements)

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“…The phenomenon here studied clearly indicates that between induction mechanisms of various regional types a systematic relationship exists, and that the physical entities govering the mechanism can be altered by heat, alcohol, and formalin, and hence might be of proteinic nature. The latter suggestion is in line with data obtained in more direct approach (YAMADA and TAKATA, 1955;TIEDE-M A N N and TIEDEMANN, 1956;HAYASHI, 1958;YAMADA, 1958a, b, c ) .…”

Section: Arch Encephalicsupporting

confidence: 86%

“…The latter suggestion is in line with data obtained in more direct approach (YAMADA and TAKATA, 1955;TIEDE-M A N N and TIEDEMANN, 1956;HAYASHI, 1958;YAMADA, 1958a, b, c ) .…”

Section: Arch Encephalicsupporting

confidence: 77%

“…As this type of experiments is now under way, the discussion of the question should be reserved for a later occasion. Here it will suffice to mention that a few similar experiments done at our laboratory using nucleoprotein samples gave results which support the second possibility raised above: A short heat-treatment of a sample of liver pentose nucleoprotein suppressed the deuterencephalic tendency, and increased at the same time the archencephalic tendency (HAYASHI, 1958) : In a sample of kidney pentose nucleoprotein a short incubation with pepsin evoked a complete suppression of the spino-caudal tendency and appearance of the archencephalic tendency ( HAYASHI, in preparation, cf. YAMADA, 1958a).…”

Section: Arch Encephalicsupporting

confidence: 67%

“…According to the recent progress made in this field, it appears probable that characteristic effects of most of those differentiated tissues are caused by some of their chemical components of macromolecular order ( HAYASHI, 1956( HAYASHI, ,1958TIEDEMANN and TIEDEMANN, 1956;YAMADA and TAKATA, 1936;YAMADA, 1958a, b, c;HAYASHI and TAKATA, 1958). Some samples of proteins or pentose nucleoproteins isolated from those tissues have been shown to induce definite regional structures in the ectoderm of Triturus.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A PROGRESSIVE CHANGE IN REGIONAL INDUCTIVE EFFECTS OF THE BONE‐MARROW CAUSED BY HEAT‐TREATMENT¹⁾

Yamada

1959

Embryologia

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Section: Arch Encephalicsupporting

confidence: 86%

“…The latter suggestion is in line with data obtained in more direct approach (YAMADA and TAKATA, 1955;TIEDE-M A N N and TIEDEMANN, 1956;HAYASHI, 1958;YAMADA, 1958a, b, c ) .…”

Section: Arch Encephalicsupporting

confidence: 77%

Section: Arch Encephalicsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A PROGRESSIVE CHANGE IN REGIONAL INDUCTIVE EFFECTS OF THE BONE‐MARROW CAUSED BY HEAT‐TREATMENT¹⁾

Yamada

1959

Embryologia

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Induction by desoxyribonucleic acids of axial structures in post‐nodal fragments of chick blastoderms

Butros¹

1960

J. Exp. Zool.

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Nerve growth factor induces neural differentiation in undifferentiated cells of early chick embryos

1985

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Nerve growth factor (NGF) induced differentiation in postnodal pieces (PNPs) of stage 4 chick embryos. This induction was highly selective for neural tissue; no other structures developed in the NGF-treated PNPs. Furthermore, the number of PNPs showing neural differentiation was dependent on the concentration of NGF, but there was no correlation between the concentration of NGF (5-100 ng/ml) and extent of neuralization. The neural inducing capacity of NGF could be abolished by anti-NGF antibody. NGF-induced neural differentiation was accompanied by elevated intracellular levels of cyclic AMP. Exogenous cyclic AMP (175 micrograms/ml) was able to stimulate neural differentiation but, unlike NGF, induced other structures (e.g., notochord and pulsatile tissue). Overall results suggest that cells from chick embryos at developmental stages much earlier than previously thought are responsive to NGF and NGF or a a closely related substance may serve as a neural inducer in the chick embryo.

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THE EFFECTS OF PEPSIN AND TRYPSIN ON THE INDUCTIVE ABILITY OF PENTOSE NUCLEOPROTEIN FROM GUINEA PIG LIVER¹⁾

Cited by 28 publications

References 15 publications

A PROGRESSIVE CHANGE IN REGIONAL INDUCTIVE EFFECTS OF THE BONE‐MARROW CAUSED BY HEAT‐TREATMENT¹⁾

A PROGRESSIVE CHANGE IN REGIONAL INDUCTIVE EFFECTS OF THE BONE‐MARROW CAUSED BY HEAT‐TREATMENT¹⁾

Induction by desoxyribonucleic acids of axial structures in post‐nodal fragments of chick blastoderms

Nerve growth factor induces neural differentiation in undifferentiated cells of early chick embryos

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THE EFFECTS OF PEPSIN AND TRYPSIN ON THE INDUCTIVE ABILITY OF PENTOSE NUCLEOPROTEIN FROM GUINEA PIG LIVER1)

Cited by 28 publications

References 15 publications

A PROGRESSIVE CHANGE IN REGIONAL INDUCTIVE EFFECTS OF THE BONE‐MARROW CAUSED BY HEAT‐TREATMENT1)

A PROGRESSIVE CHANGE IN REGIONAL INDUCTIVE EFFECTS OF THE BONE‐MARROW CAUSED BY HEAT‐TREATMENT1)

Induction by desoxyribonucleic acids of axial structures in post‐nodal fragments of chick blastoderms

Nerve growth factor induces neural differentiation in undifferentiated cells of early chick embryos

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Product

Resources

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THE EFFECTS OF PEPSIN AND TRYPSIN ON THE INDUCTIVE ABILITY OF PENTOSE NUCLEOPROTEIN FROM GUINEA PIG LIVER¹⁾

A PROGRESSIVE CHANGE IN REGIONAL INDUCTIVE EFFECTS OF THE BONE‐MARROW CAUSED BY HEAT‐TREATMENT¹⁾

A PROGRESSIVE CHANGE IN REGIONAL INDUCTIVE EFFECTS OF THE BONE‐MARROW CAUSED BY HEAT‐TREATMENT¹⁾