1992
DOI: 10.1002/j.1552-4604.1992.tb03844.x
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The Effects of Pentoxifylline on the Plasma Membrane Ca2+ ATPase in Age‐Separated Rat and Human Erythrocytes

Abstract: Pentoxifylline, a dimethyl xanthine derivative given to patients with peripheral vascular disorders, increases erythrocyte deformability, diminishes Ca2+ entry, inhibits Ca(2+)-dependent transglutaminase activity and elevates ATP levels. The present study examined the effects of pentoxifylline on the Ca2+ pump ATPase, an enzyme which regulates intracellular Ca2+ levels. Studies were carried out with inside-out vesicles (IOVs) prepared from young (Ey) and old (Eo) human and rat erythrocytes. The pumping of Ca2+… Show more

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Cited by 8 publications
(3 citation statements)
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“…Pentoxyphilline also affected Ca 2+ uptake activity. The early burst of Ca 2+ uptake decreased in the vesicles from young but not from older erythrocytes (165).…”
Section: Abnormalities In Erythrocyte Camentioning
confidence: 79%
“…Pentoxyphilline also affected Ca 2+ uptake activity. The early burst of Ca 2+ uptake decreased in the vesicles from young but not from older erythrocytes (165).…”
Section: Abnormalities In Erythrocyte Camentioning
confidence: 79%
“…The nucleotide boosts the cellular glycolysis with rising endogenous ATP production. Nevertheless, other known effects cannot be discarded: e.g., modification of calcium transport [26], antagonism to endogenous adenosine actions [11], or inhibition of generation of reactive oxygen species [13,23,34] whose deleterious effects upon sperm functional activity have been previously reported [1].…”
Section: Discussionmentioning
confidence: 99%
“…That is to say, the response of animals to PTX treatment was more significant when they were older ( Kaapa et al, 1991 ; Raj et al, 1992 ). Erythrocytes isolated from young and aged rats were also different in their sensitivity to PTX treatment ( Seidler and Swislocki, 1992 ). More specifically, PTX improved natural aging rats’ learning and memory ability and significantly reversed the rats’ age-dependent spatial memory defect ( de Toledo-Morrell et al, 1984 ; Hu et al, 2007 ).…”
Section: Introductionmentioning
confidence: 99%