The effects of packaging on the stability of a moisture sensitive compound

Allinson, Jennifer G; Dansereau, Richard J.; Sakr, Adel

doi:10.1016/s0378-5173(01)00670-6

Cited by 52 publications

(32 citation statements)

References 2 publications

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“…The form of Eq (1) indicates that chemical instability for API degradation in solid dosage forms increases exponentially with an increase in RH. In absolute terms, this dependence will vary with the B-term.…”

Section: Chemical Stabilitymentioning

confidence: 99%

“…This review aims to lay out a rational process for package selection based on predicting drug product shelf-life in different packaging configurations. While many aspects of packaging selection have been developed and published previously, [1][2][3][4] this review attempts to provide a focus on moisture sensitivity and how packaging can be chosen to provide adequate product shelf-life while balancing cost and marketing needs.…”

Section: Introductionmentioning

confidence: 99%

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Package Selection for Moisture Protection for Solid, Oral Drug Products

Waterman

MacDonald

2010

Journal of Pharmaceutical Sciences

101

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Section: Chemical Stabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Package Selection for Moisture Protection for Solid, Oral Drug Products

Waterman

MacDonald

2010

Journal of Pharmaceutical Sciences

101

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“…Co., China). Its average particle size was 4.5 m, density 1.66 g/cm 3 and specific surface area 533 g/m 2 as determined by nitrogen adsorption (BET). The theoretical pore diameter of this zeolite is 4.3 Å.…”

Section: Methodsmentioning

confidence: 99%

“…A wide range of functions can be introduced into these materials like electrical and thermal properties, piezoelectric response, desiccant characteristics, antiseptic properties, etc. Desiccant characteristic are used mainly in the packaging industry, the most frequently in electronics [2] and pharma [3][4][5]; they can be achieved by combining polymers with fillers which adsorb or absorb water. The simplest and industrially most viable solution is the use of a desiccant filler, usually a silica gel [6] or zeolite [7].…”

Section: Introductionmentioning

confidence: 99%

Interfacial interactions and reinforcement in thermoplastics/zeolite composites

Kajtár

Kenyó

Renner

et al. 2017

Composites Part B: Engineering

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“…The main functions targeted for various products are small oxygen permeability or oxygen scavenging [5][6][7], humidity control [8][9][10][11][12], regulated ethylene content [13], antimicrobial effect [14][15][16][17], adsorption of odorous materials, or the opposite, the release of desirable aromas [18,19]. Intensive research and development work is carried out on these materials all over the world, but mostly in industry.…”

mentioning

confidence: 99%

Decreased oxygen permeability of EVOH through molecular interactions

Péter¹,

Kenyó²,

Renner³

et al. 2014

Express Polym. Lett.

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The number of functional and smart packaging materials increases continuously and they are used already in everyday practice in increasing quantities [1][2][3][4]. The main functions targeted for various products are small oxygen permeability or oxygen scavenging [5][6][7], humidity control [8][9][10][11][12], regulated ethylene content [13], antimicrobial effect [14][15][16][17], adsorption of odorous materials, or the opposite, the release of desirable aromas [18,19]. Intensive research and development work is carried out on these materials all over the world, but mostly in industry.Controlling oxygen permeability is especially important in the pharmaceutical industry and in food packaging. The oxygen permeability of polymers varies in a wide range covering several orders of magnitudes from a few hundred to a few hundredths or even thousands of cm 3· mm/m 2 /24 h/bar [20]. Ethylene-vinyl alcohol copolymers (EVOH) offer extremely good protection against oxygen [20][21][22][23][24][25]. The barrier properties of these materials depend on ethylene content [23,26,27], crystallinity, temperature [22,28] and humidity [24,[26][27][28][29][30][31][32][33][34]. The last factor represents also the major drawback of EVOH, since permeability may increase by orders of magnitudes with increasing water content [28] Abstract. Poly(ethylene-co-vinyl alcohol) of 48 mol% ethylene content was modified with N,N!-bis(2,2,6,6-tetramethyl-4-piperidyl)-isophthalamide (Nylostab SEED) to decrease the oxygen permeability of the polymer. The additive was added in a wide concentration range from 0 to 10 wt%. The structure and properties of the polymer were characterized with various methods including differential scanning calorimetry, X-ray diffraction, mechanical testing, optical measurements and oxygen permeation. Interactions were estimated by molecular modeling and infrared spectroscopy. The results showed that oxygen permeation decreased considerably when the additive was added at less than 2.0 wt% concentration. The decrease resulted from the interaction of the hydroxyl groups of the polymer and the amide groups of the additive. The dissolution of the additive in the polymer led to decreased crystallinity, but also to decreased mobility of amorphous molecules. Stiffness and strength, but also deformability increased as a result. Above 2 wt% the additive forms a separate phase leading to the deterioration of properties. The success of the approach represents a novel way to control oxygen permeation in EVOH and in other polymers with similar functional groups capable of strong interactions.

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The effects of packaging on the stability of a moisture sensitive compound

Cited by 52 publications

References 2 publications

Package Selection for Moisture Protection for Solid, Oral Drug Products

Package Selection for Moisture Protection for Solid, Oral Drug Products

Interfacial interactions and reinforcement in thermoplastics/zeolite composites

Decreased oxygen permeability of EVOH through molecular interactions

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