The effects of ozone therapy and coenzyme Q10 combination on oxidative stress markers in healthy subjects

İnal, Mine; Dokumacıoğlu, Ali; Özçelik, Eda; Uçar, Ömer

doi:10.1007/s11845-011-0675-7

Cited by 50 publications

(34 citation statements)

References 23 publications

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“…The main benefits of ozone therapy on humans are: the antibiotic effect and static effect on viruses, [1][2][3][4] activation of the mitochondrial antioxidant system, [5][6][7] increased adenosine triphosphate (ATP) production, hemorheological effect with greater activity of the oxygen-carbon dioxide exchange in red blood cells, 8 and anti-inflammatory action. 9 In addition, there is reactivation of the cerebral microcirculation and metabolism, 7 an anti-ischemic protective effect, [10][11][12] antithrombotic effect, 13 and anti-tumor action.…”

Section: Introductionmentioning

confidence: 99%

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

et al. 2017

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Ozone major autohemotherapy (O-MAHT) is a way of ozonetherapy administration consisting of drawing patient's venous blood, mixing with oxygen/ozone, and reinfusing it into the vein. Some ozone therapists reported side effects during the O-MAHT, but the origin has not been described yet. We investigated the effect of blood drawing velocity during O-MAHT to see its effects on the vascular system and symptomatology. We administered O-MAHT to 11 subjects, and we interleaved fast and slow reinfusions. We monitored cerebral macrocirculation with transcranial Doppler (TCD) and tissue microcirculation with near-infrared spectroscopy (NIRS). Annoying symptoms appeared just during the fast reinfusion periods. NIRS and TCD parameters revealed vasoconstriction during fast reinfusion and improved metabolism during slow reinfusion. Overall, our investigation well discriminated fast from slow reinfusion velocity.

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Section: Introductionmentioning

confidence: 99%

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

et al. 2017

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“…antioxidant systems (8,9). Furthermore, it has been reported that ozone oxidative preconditioning (OOP), a type of ozone therapy (10) has a protective effect against IRI in the liver and kidney (11,12).…”

Section: Effect Of Ozone Oxidative Preconditioning On Oxidative Stresmentioning

confidence: 99%

Effect of ozone oxidative preconditioning on oxidative stress injury in a rat model of kidney transplantation

Qiu

Wang

Liu

et al. 2017

Experimental and Therapeutic Medicine

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The aim of the present study was to investigate the protective effect of ozone oxidative preconditioning (OOP) on renal oxidative stress injury in a rat model of kidney transplantation. Thirty-six male Sprague Dawley (SD) rats were randomly divided into three groups: A sham (S) group, a kidney transplantation (KT) group and an OOP and kidney transplantation (OOP+KT) group. In the S group, the rats' abdomens were opened and closed without transplantation. In the KT group, the rats received a left kidney from donor SD rats. In the OOP+KT group, donor SD rats received 15 OOP treatments by transrectal insufflations (1 mg/kg), once a day, at an ozone concentration of 50 µg/ml, before the kidney transplantation. Twenty-four hours after transplantation, the parameters of renal function of the recipients were measured. The morphology and pathological effects of renal allograft were examined using hematoxylin and eosin staining, periodic acid-Schiff staining, a terminal deoxynucleotidyl transferase dUTP nick end labeling assay and immunohistochemistry. Markers of oxidative stress were also detected using the thiobarbituric acid method, and expression levels of Nrf-2 and HO-1 were determined by western blot analysis. Blood urea nitrogen and creatinine levels were significantly decreased in the OOP+KT group compared with the KT group, and the morphology and pathological changes of renal allograft were also less severe. Meanwhile, the renal allograft cell apoptosis index was significantly higher in the KT group compared to the OOP+KT group (P<0.05). Levels of superoxide dismutase, glutathione and catalase in the renal allografts were significantly higher in the OOP+KT group compared to those in the KT group (P<0.05), while malondialdehyde levels were significantly lower in the OOP+KT group compared to those in the KT group (P<0.05). Western blot analysis indicated that the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf-2) and heme oxygenase 1 (HO-1) were significantly higher in the OOP+KT compared to the KT group (P<0.05). In conclusion, the mechanism by which OOP alleviates oxidative stress injury in renal transplantation may be related to the activation of the signaling pathways of Nrf-2/HO-1 and inhibition of renal tubular epithelial cell apoptosis.

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“…Some report has showed that ozone had numerous abilities, ozone therapy could be used to treat infected wound and empyrosis 1 . Furthermore, researches have showed that ozone therapy could enhance the function of anti-oxidative system, which could mitigate the damage coused by oxidative stress 2,3 . However, to our knowledge, the effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in the homologous kidney transplantation has not been studied up till now.…”

Section: ■ Introductionmentioning

confidence: 99%

Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation

et al. 2018

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The effects of ozone therapy and coenzyme Q10 combination on oxidative stress markers in healthy subjects

Abstract: The results of this study reveal the beneficial effects of ozone therapy + coenzyme Q(10) combination in prevention of oxidative damage.

Cited by 50 publications

References 23 publications

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

Effect of ozone oxidative preconditioning on oxidative stress injury in a rat model of kidney transplantation

Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation

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