The Effects of Oxidative Stress on the Liver and Ileum in Rats Caused by One-Lung Ventilation

Yuluğ, Esin; Tekinbaş, Celal; Ulusoy, Hülya; Alver, Ahmet; Yenilmez, Engin; Aydin, Sevim; Çekiç, Bahanur; Topbaş, Murat; İmamoğlu, Mustafa; Arvas, Haluk

doi:10.1016/j.jss.2006.08.041

Cited by 22 publications

(18 citation statements)

References 37 publications

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“…Imai et al found that injurious ventilation with high tidal volumes elicited the elevation of AST and LDH and more apoptosis in the kidney and small intestine, but not in the liver [24]. One-lung ventilation caused elevations of serum AST, ALT and liver myeloperoxidase activity, liver cell apoptosis and microscopic signs of hepatic damage [25]. Injurious mechanical ventilation in mice increased the expression of adhesion molecules associated with recruitment of granulocytes into the liver and kidney [26].…”

Section: Discussionmentioning

confidence: 99%

Hepatic effects of lung-protective pressure-controlled ventilation and a combination of high-frequency oscillatory ventilation and extracorporeal lung assist in experimental lung injury

et al. 2011

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SummaryBackgroundVentilation with high positive end-expiratory pressure (PEEP) can lead to hepatic dysfunction. The aim of this study was to investigate the hepatic effects of strategies using high airway pressures either in pressure-controlled ventilation (PCV) or in high-frequency oscillatory ventilation (HFOV) combined with an arteriovenous extracorporeal lung assist (ECLA).Material/MethodsPietrain pigs underwent induction of lung injury by saline lavage. Ventilation was continued for 24 hours either as PCV with tidal volumes of 6 ml/kg and PEEP 3 cmH2O above the lower inflection point of the pressure-volume curve or as HFOV (≥12 Hz) with a mean tracheal airway pressure 3 cmH2O above the lower inflection point combined with arteriovenous ECLA (HFOV+ECLA). Fluids and norepinephrine stabilized the circulation. The indocyanine green plasma disappearance rate, serum bilirubin, aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, glutamate dehydrogenase, lactate dehydrogenase and creatine kinase were determined repeatedly. Finally, liver neutrophils were counted and liver cell apoptosis was assessed by terminal deoxynucleotidyl transferase nick end labeling (TUNEL).ResultsAspartate aminotransferase increased in the PCV group about three-fold and in the HFOV+ECLA group five-fold (p<0.001). Correspondingly, creatine kinase increased about two-fold and four-fold, respectively (p<0.001). Lactate dehydrogenase was increased in the HFOV+ECLA group (p<0.028). The number of neutrophils infiltrating the liver tissue and the apoptotic index were low.ConclusionsHigh airway pressure PCV and HFOV with ECLA in the treatment of lavage-induced lung injury in pigs did not cause liver dysfunction or damage. The detected elevation of enzymes might be of extrahepatic origin.

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Section: Discussionmentioning

confidence: 99%

Hepatic effects of lung-protective pressure-controlled ventilation and a combination of high-frequency oscillatory ventilation and extracorporeal lung assist in experimental lung injury

et al. 2011

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“…Systemic effects of VALI can also be seen, and are likely mediated by spillover of proinflammatory cytokines to the blood circulation [23]. They include liver injury [23], natural-killer cells (NK) impairment [24], and cardiac arrhythmias [25].…”

Section: General Principlesmentioning

confidence: 99%

“…They include liver injury [23], natural-killer cells (NK) impairment [24], and cardiac arrhythmias [25]. Despite these complications are usually self-limiting and well treatable, they can trigger potentially life-threatening deterioration in more fragile patients.…”

Section: General Principlesmentioning

confidence: 99%

Nonintubated Videothoracoscopic Operations in Thoracic Oncology

Mineo¹,

Tacconi²

2014

J de Chirurgie

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“…The left lateral lobe of the liver and the right lung were stained with hematoxylin and eosin (HE) for standard histological examination [18]. A pathologist blinded to the treatment groups subjected the tissues to microscopic examination and graded each slide on a scale of 0 to 3 (0 ¼ normal, 3 ¼ most severe) [19,20].…”

Section: Histologic Changesmentioning

confidence: 99%

“…A pathologist blinded to the treatment groups subjected the tissues to microscopic examination and graded each slide on a scale of 0 to 3 (0 ¼ normal, 3 ¼ most severe) [19,20]. The extent of liver and lung apoptosis were also determined using terminal dUTP nicklabeling (TUNEL), as described previously [18].…”

Section: Histologic Changesmentioning

confidence: 99%

Emulsified Isoflurane Preconditioning Protects Against Liver and Lung Injury in Rat Model of Hemorrhagic Shock

Zhang

Luo

Liu

et al. 2011

Journal of Surgical Research

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The Effects of Oxidative Stress on the Liver and Ileum in Rats Caused by One-Lung Ventilation

Cited by 22 publications

References 37 publications

Hepatic effects of lung-protective pressure-controlled ventilation and a combination of high-frequency oscillatory ventilation and extracorporeal lung assist in experimental lung injury

Hepatic effects of lung-protective pressure-controlled ventilation and a combination of high-frequency oscillatory ventilation and extracorporeal lung assist in experimental lung injury

Nonintubated Videothoracoscopic Operations in Thoracic Oncology

Emulsified Isoflurane Preconditioning Protects Against Liver and Lung Injury in Rat Model of Hemorrhagic Shock

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