The effects of ovariectomy on the mechanical properties of skin in rats

Özyazgan, İrfan; Lïman, Narin; Dursun, Nurcan; Güneş, İbrahim

doi:10.1016/s0378-5122(02)00181-0

Cited by 38 publications

(27 citation statements)

References 27 publications

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“…Most naturally derived biomaterials have a viscoelastic property and show a wide range of strength values, such as collagen fibers of cartilage (1-7 MPa), collagen gels of calf skin (0.001-0.009 MPa), heart muscles of rats/humans (0.003-0.07 MPa), and skin of rat (6.58-9.52 MPa). 18,19 The results observed in the mechanical testing suggest that the decellularized placenta-derived ECM sheet has appropriate mechanical characteristics for use as a skin substitute.…”

Section: Physicomechanical Properties Of Decellularized Ecm Sheetsmentioning

confidence: 99%

“…In fact, the strength of the ECM sheet was significantly lower compared with rat normal skin. 19 However, the higher turnover rate of collagen in an ECM sheet may promote more rapid infiltration of host cells to the wound and more prompt wound stabilization. 41 In addition, bFGF is known to reduce wound contraction by inhibiting the phenotypic change of fibroblasts to myofibroblasts, which is likely to be involved in contraction.…”

Section: Full-thickness Wound Healing Using Human Placenta Ecmmentioning

confidence: 99%

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Full-Thickness Skin Wound Healing Using Human Placenta-Derived Extracellular Matrix Containing Bioactive Molecules

Choi

Kim

Yoon

et al. 2013

Tissue Engineering Part A

124

122

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The human placenta, a complex organ, which facilitates exchange between the fetus and the mother, contains abundant extracellular matrix (ECM) components and well-preserved endogenous growth factors. In this study, we designed a new dermal substitute from human placentas for full-thickness wound healing. Highly porous, decellularized ECM sheets were fabricated from human placentas via homogenization, centrifugation, chemical and enzymatic treatments, molding, and freeze-drying. The physical structure and biological composition of human placenta-derived ECM sheets dramatically supported the regeneration of full-thickness wound in vivo. At the early stage, the ECM sheet efficiently absorbed wound exudates and tightly attached to the wound surface. Four weeks after implantation, the wound was completely closed, epidermic cells were well arranged and the bilayer structure of the epidermis and dermis was restored. Moreover, hair follicles and microvessels were newly formed in the ECM sheet-implanted wounds. Overall, the ECM sheet produced a dermal substitute with similar cellular organization to that of normal skin. These results suggest that human placenta-derived ECM sheets provide a microenvironment favorable to the growth and differentiation of cells, and positive modulate the healing of full-thickness wounds.

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Section: Physicomechanical Properties Of Decellularized Ecm Sheetsmentioning

confidence: 99%

Section: Full-thickness Wound Healing Using Human Placenta Ecmmentioning

confidence: 99%

Full-Thickness Skin Wound Healing Using Human Placenta-Derived Extracellular Matrix Containing Bioactive Molecules

Choi

Kim

Yoon

et al. 2013

Tissue Engineering Part A

124

122

View full text Add to dashboard Cite

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“…The most common failure tests of skin are tensile tests [25,[29][30][31][32][33][34][35][36][37][38][39][40][41], piercing tests [25,[42][43][44][45][46][47][48][49][50][51][52][53] and tearing tests [54][55][56]. In spite of these studies, the failure characteristics of skin are still not clearly established yet.…”

Section: Skin Failurementioning

confidence: 99%

Biothermomechanical behavior of skin tissue

Seffen

2008

Acta Mech. Sin.

127

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Advances in laser, microwave and similar technologies have led to recent developments of thermal treatments involving skin tissue. The effectiveness of these treatments is governed by the coupled thermal, mechanical, biological and neural responses of the affected tissue: a favorable interaction results in a procedure with relatively little pain and no lasting side effects. Currently, even though each behavioral facet is to a certain extent established and understood, none exists to date in the interdisciplinary area. A highly interdisciplinary approach is required for studying the biothermomechanical behavior of skin, involving bioheat transfer, biomechanics and physiology. A comprehensive literature review pertinent to the subject is presented in this paper, covering four subject areas: (a) skin structure, (b) skin bioheat transfer and thermal damage, (c) skin biomechanics, and (d) skin biothermomechanics. The major problems, issues, and topics for further studies are also outlined. This review finds that significant advances in each of these aspects have been achieved in recent years. Although focus is placed upon the biothermomechanical behavior of skin tissue, the fundamental concepts and methodologies reviewed in this paper may also be applicable for studying other soft tissues.

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“…Oestrogenic and androgenic receptors are present in the cells of the epidermis, hair follicles, and their associated pilosebaceous structures, and in the apocrine sweat glands. There is evidence that the hypooestrogenic stage of the organism causes significant changes in the physical characteristics of the skin and decreases its biomechanical quality (3,11,19,20).…”

Section: Discussionmentioning

confidence: 99%

“…Microscopic images of the skin in such cases usually show reduction or enlargement of the thickness of certain layers of the skin, changes in the structure of collagen fibrils, elastosis, wrinkles, hyperpigmentation, hair thinning, reduction in size and number of sebaceous glands, and storage of atypical lipids and cholesterol droplets in the hypodermis (3,4,11,20). It is known that thymus hormones have an effect on skin-associated lymphoid tissue (SALT) (18).…”

Section: Introductionmentioning

confidence: 99%

Curative effect of TFX-Jelfa supplementation on the skin of ovariectomised rats – morphological study

Karpińska

Szpringer

Lutnicki

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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The aim of this study was to assess the effect of thymus factor X (TFX-Jelfa) treatment in hypoestrogenic female rats for the purpose of decreasing skin impairments. Ovariectomised rats were used as a model. The histopathological analysis of the skin after TFX-Jelfa treatment demonstrated that the epidermis was thicker and more desquamated, without deep wrinkles or hypersecretion in comparison to the skin of animals only castrated and not treated with TFX-Jelfa. Collagen and elastic fibres were arranged more uniformly in the dermis and there were numerous fibroblasts, hair follicles, and small vessels. Ultrastructural analysis showed keratinocytes without degenerative changes and the proliferation of lymphatic and dendritic cells in the skin. The results indicate that thymus extracts can have beneficial effects on skin aging, which is often accompanied by hormonal perturbances.

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The effects of ovariectomy on the mechanical properties of skin in rats

Cited by 38 publications

References 27 publications

Full-Thickness Skin Wound Healing Using Human Placenta-Derived Extracellular Matrix Containing Bioactive Molecules

Full-Thickness Skin Wound Healing Using Human Placenta-Derived Extracellular Matrix Containing Bioactive Molecules

Biothermomechanical behavior of skin tissue

Curative effect of TFX-Jelfa supplementation on the skin of ovariectomised rats – morphological study

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