The Effects of Other Drugs on the Stimulation of Laryngospasm in the Cat: Atropine; Thiopentone; Suxamethonium; Local Analgesics

Rex, M. A. E.

doi:10.1093/bja/43.2.117

Cited by 10 publications

(8 citation statements)

References 6 publications

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“…). The use of NMBAs to facilitate intubation in cats is not a new concept; succinylcholine was evaluated for this purpose (Rex ) and, more recently, rocuronium was used (Moreno‐Sala et al. ).…”

Section: Introductionmentioning

confidence: 99%

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Prevention of laryngospasm with rocuronium in cats: a dose-finding study

Martin‐Flores

Sakai

Portela

et al. 2016

Veterinary Anaesthesia and Analgesia

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Section: Introductionmentioning

confidence: 99%

“…Traumatic lesions have been attributed to intubation in nonparalyzed cats (Hofmeister et al 2007). The use of NMBAs to facilitate intubation in cats is not a new concept; succinylcholine was evaluated for this purpose (Rex 1971) and, more recently, rocuronium was used (Moreno-Sala et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Prevention of laryngospasm with rocuronium in cats: a dose-finding study

Martin‐Flores

Sakai

Portela

et al. 2016

Veterinary Anaesthesia and Analgesia

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“…Previous research reports that topical lidocaine reduces the laryngeal reflex in response to mechanical stimulation. 2,4,8,9 This study reported increased laryngeal relaxation at 45 s when compared with 5 s after lidocaine application. Mucosal mechanoreceptors are responsible for eliciting the laryngeal adductor response.…”

Section: Discussionmentioning

confidence: 62%

Evaluation of the time to desensitization of the larynx of cats following topical lidocaine application

Jones

Boyer

Chapman

et al. 2020

Journal of Feline Medicine and Surgery

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Objectives The objective of this study was to evaluate the time to decreased reactivity of the arytenoid cartilages in cats after application of topical lidocaine. Methods One hundred and ten mixed-breed cats were randomly assigned to one of five groups based on the time between application of lidocaine and stimulation of the larynx: 5 (T5), 15 (T15), 30 (T30), 45 (T45) or 60 (T60) s. Cats were premedicated with dexmedetomidine, ketamine and buprenorphine. Anesthesia was induced with propofol to effect. Lidocaine 2% (2 mg/kg) was applied topically to the vocal cords using a catheter attached to a syringe under direct laryngoscopy. After lidocaine application, the designated time elapsed and the vocal cords were stimulated with the patient end of an endotracheal tube. Severity of reaction was reported as none, mild, moderate or severe. All cats were intubated after the reactivity score was recorded. Anesthesia was maintained with isoflurane and 100% oxygen while cats were spayed or neutered. Cats were monitored in recovery for signs of respiratory complications and pain. Results There was a significant difference in overall reactivity score between T5 and T45 ( P = 0.0038). Also, there was a significant difference in the number of cats with no reaction compared with cats with any reaction between T5 and T30 ( P = 0.03), as well as between T5 and T45 ( P = 0.0028). No cat had a severe reactivity score at T45 or T60. All cats were successfully intubated. There were no complications during intubation, maintenance of anesthesia or recovery. Conclusions and relevance As the lowest overall reactivity score occurred at T45, it is recommended to wait at least 45 s after application of topical lidocaine before attempting tracheal intubation.

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“…Other authors also stated that at a dose rate of 1.2 mg per anesthetized cat, atropine failed to alter the coughing response (Harrison and Vanik, 1963). Another study used atropine sulphate for cat premedication and stated that atropine did not affect the stimulated formation of laryngospasm using ether (Rex, 1971).…”

Section: Resultsmentioning

confidence: 99%

Effect of Atropine Sulphate on Laryngeal Accessibility and Visibility for Swine Intubation

Zigmantaitė

Jonušaitė

Grigalevičiūtė

et al. 2022

ASD

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Background: Animal intubation is necessary in painful surgery procedures in order to maintain general anaesthesia and analgesia. In swine, orotracheal intubation is difficult or impossible; all possible measures to improve it need to be explored. Methods: Two groups of a total of 20 clinically healthy local mixed breed (Sus scrofa domesticus) premedicated swine underwent intubation. The animals were randomly divided into two groups, one using atropine sulphate (A) and one using saline solution (N), prior to endotracheal intubation. Premedication started with intramuscular injection of xylazine, ketamine and fentanyl. Intubation was performed after induction with thiopental sodium administered intravenously with atropine sulphate or saline solution. Larynxes were photographed and filmed and coded images and videos were sent to investigators for evaluation. Result: In this study, a negative effect of atropine sulphate on the laryngeal visibility, opening and accessibility in local mixed breed anesthetized pigs was identified.

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The Effects of Other Drugs on the Stimulation of Laryngospasm in the Cat: Atropine; Thiopentone; Suxamethonium; Local Analgesics

Cited by 10 publications

References 6 publications

Prevention of laryngospasm with rocuronium in cats: a dose-finding study

Prevention of laryngospasm with rocuronium in cats: a dose-finding study

Evaluation of the time to desensitization of the larynx of cats following topical lidocaine application

Effect of Atropine Sulphate on Laryngeal Accessibility and Visibility for Swine Intubation

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