The Effects of Osteoporotic and Non-osteoporotic Medications on Fracture Risk and Bone Mineral Density

Burgh, Anna C van der; Keyser, Catherine E. de; Zillikens, M. Carola; Stricker, Bruno H. Ch.

doi:10.1007/s40265-021-01625-8

Cited by 28 publications

(14 citation statements)

References 418 publications

(557 reference statements)

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“…In addition, the BMD at distal forearm decreased when the duration of menopause increased (Pearson's r = -0.455) as indicated in Fig. (6).…”

Section: Resultsmentioning

confidence: 81%

“…It is possible that race or ethnicity contributes to BMD [8 -16]. In addition, other risk factors also contribute to the prevalence of osteoporosis including physical body, behaviors and nutritional status [6,17]. Hence, the populations in each of these countries, or different areas of the same country have dissimilar incidents of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

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Bone Mineral Density at Distal Forearm in Women in Mae Chaem District, Chiang Mai Province, Thailand: A Cross-Sectional Study

Thumvijit¹,

Sriburee²,

Padngam³

et al. 2022

TOPHJ

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Background: Osteoporosis is a common health problem worldwide and has a high impact on quality of life and economic losses. However, having an early risk assessment can resolve the problem. Objective: To investigate the prevalence of bone mineral density (BMD) and osteoporosis in the distal forearm among Thai women in Mae Chaem District, Chiang Mai Province, Thailand. Methods: The subjects were 456 women, aged between 24-88 years who inhabit Mae Chaem District, Chiang Mai Province, Thailand. The demographic characteristics data was obtained by using self-administered questionnaires that determine common risk factors for osteoporosis. The BMD of the non-dominant distal forearm of all subjects was determined according to standard protocol by use of peripheral dual energy X-ray absorptiometry (pDEXA) scanning. Results: The BMD decreased as a function of age (Pearson's r = -0.645) while the BMD increased as a function of weight (Pearson's r = 0.389), and height (Pearson's r = 0.267). The percentage of prevalence is increased as a function of age-group in osteoporosis group, while it is decreased in that of normal bone density. In addition, the BMD at distal forearm decreased when the duration of menopause increased (Pearson's r = -0.455) Conclusion: The prevalence of osteoporosis was found in the women who reside in Mae Chaem District, Chiang Mai Province, Thailand. The current study will provide the information to guide the strategies for preventing osteoporosis in the population.

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“…In addition, the BMD at distal forearm decreased when the duration of menopause increased (Pearson's r = -0.455) as indicated in Fig. (6).…”

Section: Resultsmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density at Distal Forearm in Women in Mae Chaem District, Chiang Mai Province, Thailand: A Cross-Sectional Study

Thumvijit¹,

Sriburee²,

Padngam³

et al. 2022

TOPHJ

View full text Add to dashboard Cite

show abstract

“…Although bisphosphonates have satisfactory therapeutic effects, they also have some side effects. Therefore, new prevention and treatment methods for osteoporosis are critical [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review

et al. 2022

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As an insidious metabolic bone disease, osteoporosis plagues the world, with high incidence rates. Patients with osteoporosis are prone to falls and becoming disabled, and their cone fractures and hip fractures are very serious, so the diagnosis and treatment of osteoporosis is very urgent. Extracellular vesicles (EVs) are particles secreted from cells to the outside of the cell and they are wrapped in a bilayer of phospholipids. According to the size of the particles, they can be divided into three categories, namely exosomes, microvesicles, and apoptotic bodies. The diameter of exosomes is 30–150 nm, the diameter of microvesicles is 100–1000 nm, and the diameter of apoptotic bodies is about 50–5000 nm. EVs play an important role in various biological process and diseases including osteoporosis. In this review, the role of EVs in osteoporosis is systematically reviewed and some insights for the prevention and treatment of osteoporosis are provided.

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“…Disruption of this balance will lead to skeletal disorders, the most representative of which is osteoporosis [ 1 , 2 ]. Osteoporosis is characterized by low bone mass and deterioration of bone microarchitecture, resulting in increased susceptibility to fractures [ 3 ]. Therefore, developing effective drugs to prevent and treat osteoporosis is vital.…”

Section: Introductionmentioning

confidence: 99%

Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway

Zhu

et al. 2022

J Orthop Surg Res

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Background Osteoporosis is a very common skeletal disorder that increases the risk of fractures. However, the treatment of osteoporosis is challenging. Hypoxia-inducible factor-1α (HIF-1α) plays an important role in bone metabolism. Roxadustat is a novel HIF stabilizer, and its effects on bone metabolism remain unknown. This study aimed to investigate the effects of roxadustat on osteoblast differentiation and bone remodeling in an ovariectomized (OVX) rat model. Methods In vitro, primary mouse calvarial osteoblasts were treated with roxadustat. Alkaline phosphatase (ALP) activity and extracellular matrix mineralization were assessed. The mRNA and protein expression levels of osteogenic markers were detected. The effects of roxadustat on the HIF-1α and Wnt/β-catenin pathways were evaluated. Furthermore, osteoblast differentiation was assessed again after HIF-1α expression knockdown or inhibition of the Wnt/β-catenin pathway. In vivo, roxadustat was administered orally to OVX rats for 12 weeks. Then, bone histomorphometric analysis was performed. The protein expression levels of the osteogenic markers HIF-1α and β-catenin in bone tissue were detected. Results In vitro, roxadustat significantly increased ALP staining intensity, enhanced matrix mineralization and upregulated the expression of osteogenic markers at the mRNA and protein levels in osteoblasts compared with the control group. Roxadustat activated the HIF-1α and Wnt/β-catenin pathways. HIF-1α knockdown or Wnt/β-catenin pathway inhibition significantly attenuated roxadustat-promoted osteoblast differentiation. In vivo, roxadustat administration improved bone microarchitecture deterioration and alleviated bone loss in OVX rats by promoting bone formation and inhibiting bone resorption. Roxadustat upregulated the protein expression levels of the osteogenic markers, HIF-1α and β-catenin in the bone tissue of OVX rats. Conclusion Roxadustat promoted osteoblast differentiation and prevented bone loss in OVX rats. The use of roxadustat may be a new promising strategy to treat osteoporosis.

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The Effects of Osteoporotic and Non-osteoporotic Medications on Fracture Risk and Bone Mineral Density

Cited by 28 publications

References 418 publications

Bone Mineral Density at Distal Forearm in Women in Mae Chaem District, Chiang Mai Province, Thailand: A Cross-Sectional Study

Bone Mineral Density at Distal Forearm in Women in Mae Chaem District, Chiang Mai Province, Thailand: A Cross-Sectional Study

The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review

Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway

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