The Effects of Oscillatory Flow and Bulk Flow Components on Residence Time Distribution in Baffled Tube Reactors

Stonestreet, P.; Veeken, P.M.J. Van Der

doi:10.1205/026387699526809

Cited by 94 publications

(146 citation statements)

References 17 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…The value of the velocity ratio (c) is a measure of the degree of plug flow achieved [30] and can be evaluated using the tanks-in-series (TIS) model for plug flow [31].…”

Section: Continuous Operationmentioning

confidence: 99%

“…Achieving approximations to plug flow is beneficial for processes that require precise residence times or removal of back mixing. [30]. By comparing with theoretical RTD profiles, N t was evaluated and plotted against c. The range of 2 c 4 maximized N t and generated optimal plug flow conditions; however, useable degrees of plug flow can still be achieved using values of c between 2 and 10.…”

Section: Continuous Operationmentioning

confidence: 99%

“…On a rsfs [36]. The OBR offers an alternative process intensification methodology that provides a high degree of plug flow in a reactor with a much reduced length [30].…”

Section: Compact Design For Plug Flowmentioning

confidence: 99%

See 2 more Smart Citations

Biological processing in oscillatory baffled reactors: operation, advantages and potential

Harvey

et al. 2013

Interface Focus.

View full text Add to dashboard Cite

The development of efficient and commercially viable bioprocesses is essential for reducing the need for fossil-derived products. Increasingly, pharmaceuticals, fuel, health products and precursor compounds for plastics are being synthesized using bioprocessing routes as opposed to more traditional chemical technologies. Production vessels or reactors are required for synthesis of crude product before downstream processing for extraction and purification. Reactors are operated either in discrete batches or, preferably, continuously in order to reduce waste, cost and energy. This review describes the oscillatory baffled reactor (OBR), which, generally, has a niche application in performing ‘long’ processes in plug flow conditions, and so should be suitable for various bioprocesses. We report findings to suggest that OBRs could increase reaction rates for specific bioprocesses owing to low shear, good global mixing and enhanced mass transfer compared with conventional reactors. By maintaining geometrical and dynamic conditions, the technology has been proved to be easily scaled up and operated continuously, allowing laboratory-scale results to be easily transferred to industrial-sized processes. This is the first comprehensive review of bioprocessing using OBRs. The barriers facing industrial adoption of the technology are discussed alongside some suggested strategies to overcome these barriers. OBR technology could prove to be a major aid in the development of commercially viable and sustainable bioprocesses, essential for moving towards a greener future.

show abstract

“…The value of the velocity ratio (c) is a measure of the degree of plug flow achieved [30] and can be evaluated using the tanks-in-series (TIS) model for plug flow [31].…”

Section: Continuous Operationmentioning

confidence: 99%

Section: Continuous Operationmentioning

confidence: 99%

See 1 more Smart Citation

Biological processing in oscillatory baffled reactors: operation, advantages and potential

Harvey

et al. 2013

Interface Focus.

View full text Add to dashboard Cite

show abstract

“…The batch configurations have been extensively described in literature [6,[34][35][36][37][38][39][40][41]. Table 2 lists the different parameters affecting droplet size and the correspondent correlations for oscillatory baffled reactor in batch.…”

Section: Introductionmentioning

confidence: 99%

“…-the net flow Reynolds number which is related to the net flow velocity In pulsed flow, an inversion of the flow occurs at every half period because U pm /U 0 is superior to 1 [40]. According to the operating conditions (Table 5), it ranges from 1.7 to 8.3.…”

Section: Introductionmentioning

confidence: 99%

Liquid–liquid dispersion in a continuous oscillatory baffled reactor – Application to suspension polymerization

Lobry

Lasuye²,

Gourdon

et al. 2015

Chemical Engineering Journal

View full text Add to dashboard Cite

OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible.Liquid-liquid dispersion in a continuous oscillatory baffled reactor -Application to suspension polymerization b s t r a c tReducing energy costs, improving safety, minimizing waste are the current aims of chemical engineering. Process intensification in fine chemistry has been extensively studied but less work refers to heterogeneous reactions involving two liquid phases. This paper focuses on batch to continuous suspension polymerization transposition and especially on the liquid-liquid dispersion step. The main features of suspension polymerization reaction are based on (i) the initial liquid-liquid dispersion requiring a controlled size and narrow distribution and (ii) on the control of the final particle size during the agglomeration step by avoiding fouling which is a bottleneck for continuous flow. For the continuous transposition, liquid-liquid dispersion and reaction studies are carried out in continuous oscillatory baffled reactor (COBR) which is a multipurpose reactor. Its suitability to overcome the bottlenecks is demonstrated through the investigation of the oscillating and flow conditions or the dispersed phase holdup. A controlled droplet size distribution can be achieved. Oscillation is the main parameter responsible for droplet breakage. The suitable conditions to obtain stable dispersion are determined. For one of the first times, COBR is used for suspension polymerization.

show abstract

Green Chemistry in Oscillatory Baffled Reactors

Harvey¹

2013

Process Intensification for Green Chemistry

View full text Add to dashboard Cite

The Effects of Oscillatory Flow and Bulk Flow Components on Residence Time Distribution in Baffled Tube Reactors

Cited by 94 publications

References 17 publications

Biological processing in oscillatory baffled reactors: operation, advantages and potential

Biological processing in oscillatory baffled reactors: operation, advantages and potential

Liquid–liquid dispersion in a continuous oscillatory baffled reactor – Application to suspension polymerization

Green Chemistry in Oscillatory Baffled Reactors

Contact Info

Product

Resources

About