The effects of orally administered Ag, TiO 2 and SiO 2 nanoparticles on gut microbiota composition and colitis induction in mice

Chen, Hanqing; Zhao, Ruifang; Wang, Bing; Cai, Chengxu; Zheng, Lingna; Wang, Hailong; Wang, Meng; Ouyang, Hong; Zhou, Xiaoyan; Chai, Zhifang; Zhao, Yuliang; Feng, Weiyue

doi:10.1016/j.impact.2017.07.005

Cited by 144 publications

(144 citation statements)

References 46 publications

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“…Authors agree that nanosilver can be absorbed from the gastrointestinal tract into the bloodstream and induce organ toxicity and inflammatory reactions despite the absence of evident pathomorphological abnormalities. An increase in the activity of anti-inflammatory cytokinins in animal defence response to silver nanoparticles has been reported by Chen et al (2017) and Pineda et al(2012) (Table 2). In turn, Williams et al (2015) have demonstrated reduced expression of important immunomodulatory genes, including MUC3, TLR2, TLR4, GPR43, and FOXP3, especially at rat exposure to smaller sizes (10 and 75 nm) and lower doses of silver nanoparticles (9 and 18 mg/kg).…”

Section: Toxicity Of Nanoparticlessupporting

confidence: 58%

Silver and zinc nanoparticles in animal nutrition – a review

Bąkowski

Kiczorowska

Samolińska

et al. 2018

Annals of Animal Science

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The use of metal nanoparticles as supplements of animal diets does not always bring unambiguous results. There are many reports in the literature about the multifaceted effects of this type of supplementation on the animal organism. Therefore, the aim of the paper is to present the current knowledge of the possible application of nanometal forms in animal nutrition and its potential benefits and threats. The positive effect of nanoparticles used as feed additives has most frequently been reflected in an increase in body weight, higher average daily gain, or improvement of the FCR value. In some cases, however, the effect of nanoparticle addition to diets was indiscernible. The potent antibacterial activity of nanoparticles, especially against Gram-negative bacteria and Gram-positive bacteria, is regarded as a positive effect. In turn, the probability of their toxicity is a potential risk in application thereof. Supplementation of diets with nanometals has been accompanied by pathological changes in animal tissues, primarily in the pancreas, kidney, liver, rumen, abomasum, small intestine, adrenal glands, and brain. Additionally, at the the cellular level, nanoparticles were found to induce toxicity, inflammatory excitation, and cell death. Oral administration of nanoparticles induced a risk of malfunction of the nervous system and even impairment of cognitive processes in animals. The increasing knowledge of the possible toxic effects of nanoparticles on the animal organism suggests caution in their use in animal production and necessitates further precise investigations in this area.

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Section: Toxicity Of Nanoparticlessupporting

confidence: 58%

Silver and zinc nanoparticles in animal nutrition – a review

Bąkowski

Kiczorowska

Samolińska

et al. 2018

Annals of Animal Science

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“…Alterations in healthy microbial structure, a condition termed dysbiosis, may increase the propensity for a number of pathological conditions, such as IBD, obesity, metabolic syndrome, etc . It was reported that the contact with extrinsic factors, such as antibiotics, heavy metals, particulate matters (PMs), and estrogenic compounds, could initiate the pathological process . Dietary silver nanoparticles at human relevant doses for 28 d were observed to disturb the gut microbiota in mice similar to those reported in metabolic and inflammatory diseases, such as obesity .…”

Section: Introductionmentioning

confidence: 64%

“…Recently, many studies have revealed a new insight into the estimation of risk of particle exposure, suggesting the link between gut dysbiosis and the intestinal toxicity . We wonder whether the acute oral administration of SWCNTs would induce alterations in gut microbiota and be associated with its impact on intestinal tract; moreover, the changes of gut bacteria could help to provide potential avenues for the prediction of the safety applications of SWCNTs.…”

Section: Discussionmentioning

confidence: 99%

Acute Oral Administration of Single‐Walled Carbon Nanotubes Increases Intestinal Permeability and Inflammatory Responses: Association with the Changes in Gut Microbiota in Mice

Chen

Zhao

Wang

et al. 2018

Adv Healthcare Materials

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With the increasing production and widespread potential applications of single-walled carbon nanotubes (SWCNTs), the possible impacts of oral administration of SWCNTs on gastrointestinal tract at currently occupational exposure limits and potential biomedical applications should be concerned. To address the concerns, mice are orally administrated of SWCNTs at doses of 0.05, 0.5, and 2.5 mg kg body weight per day for 7 d. The investigation shows that SWCNT treatment had promoted intestinal injuries at the acute dose of 2.5 mg kg per day, including increase of histological lesion scores, intestinal permeability, and proinflammatory cytokine (IL-1β, IL-6, and TNF-α) secretion. Analysis of gut microbiota composition using 16S rRNA gene sequencing approach reveals that acute oral administration of SWCNTs induces significant shifts of the predominant microbe phyla from Firmicutes to Bacteroidetes and increases abundance of proinflammatory bacteria Alitipes_uncultured_bacterium and Lachnospiraceae bacterium A4. These notable findings suggest that SWCNT-induced intestinal injury is linked to SWCNT interaction with intestinal tract and gut bacteria and the consequent triggering of "metabolic inflammation" responses. Furthermore, the study has shown that oral administration of carbon nanomaterials, including SWCNTs, multiwalled CNTs, and graphene oxide, can lead to different inflammatory responses and specific alteration in gut microbiota in mice.

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“…Some studies reported that TiO 2 NPs altered the compositions of gut microbiota and the bacterial metabolites; however, other studies reported no obvious disturbance of gut microbiota by TiO 2 NPs. [22][23][24][25] This discrepancy may be due to multiple factors such as the difference in characteristics of TiO 2 particles, oral doses, exposure time, exposure route, and animal models. It is notable that in most of these studies, TiO 2 was administered to rodents by oral gavage, a technique that has been shown to cause stress responses that may introduce a potential confounder in gut microbiome.…”

Section: Introductionmentioning

confidence: 99%

Foodborne Titanium Dioxide Nanoparticles Induce Stronger Adverse Effects in Obese Mice than Non‐Obese Mice: Gut Microbiota Dysbiosis, Colonic Inflammation, and Proteome Alterations

Cao

Han

et al. 2020

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The recent ban of titanium dioxide (TiO2) as a food additive (E171) in France intensified the controversy on safety of foodborne‐TiO2 nanoparticles (NPs). This study determines the biological effects of TiO2 NPs and TiO2 (E171) in obese and non‐obese mice. Oral consumption (0.1 wt% in diet for 8 weeks) of TiO2 (E171, 112 nm) and TiO2 NPs (33 nm) does not cause severe toxicity in mice, but significantly alters composition of gut microbiota, for example, increased abundance of Firmicutes phylum and decreased abundance of Bacteroidetes phylum and Bifidobacterium and Lactobacillus genera, which are accompanied by decreased cecal levels of short‐chain fatty acids. Both TiO2 (E171) and TiO2 NPs increase abundance of pro‐inflammatory immune cells and cytokines in the colonic mucosa, indicating an inflammatory state. Importantly, TiO2 NPs cause stronger colonic inflammation than TiO2 (E171), and obese mice are more susceptible to the effects. A microbiota transplant study demonstrates that altered fecal microbiota by TiO2 NPs directly mediate inflammatory responses in the mouse colon. Furthermore, proteomic analysis shows that TiO2 NPs cause more alterations in multiple pathways in the liver and colon of obese mice than non‐obese mice. This study provides important information on the health effects of foodborne inorganic nanoparticles.

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The effects of orally administered Ag, TiO 2 and SiO 2 nanoparticles on gut microbiota composition and colitis induction in mice

Cited by 144 publications

References 46 publications

Silver and zinc nanoparticles in animal nutrition – a review

Silver and zinc nanoparticles in animal nutrition – a review

Acute Oral Administration of Single‐Walled Carbon Nanotubes Increases Intestinal Permeability and Inflammatory Responses: Association with the Changes in Gut Microbiota in Mice

Foodborne Titanium Dioxide Nanoparticles Induce Stronger Adverse Effects in Obese Mice than Non‐Obese Mice: Gut Microbiota Dysbiosis, Colonic Inflammation, and Proteome Alterations

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