The effects of oral treatment with transfluthrin on the urothelium of rats and its metabolite, tetrafluorobenzoic acid on urothelial cells in vitro

Yokohira, Masanao; Arnold, Lora L.; Lautraite, S.; Sheets, Larry P.; Wason, Sheila; Stahl, Bernhard; Eigenberg, D A; Pennington, Karen L.; Kakiuchi-Kiyota, Satoko; Cohen, Samuel M.

doi:10.1016/j.fct.2011.02.022

Cited by 15 publications

(8 citation statements)

References 27 publications

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“…Analysis of our limited number of plasma and brain samples at a single time‐point provides limited information about the deposition of transfluthrin in the brain, its target organ, or about the rate and extent of its metabolite detoxification and elimination. There have been a few published studies of the metabolism and excretion of transfluthrin . These have involved measurement of urinary metabolites and have provided little information about the systemic absorption, distribution, or elimination of the chemical.…”

Section: Resultsmentioning

confidence: 99%

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Gas chromatography/negative chemical ionization mass spectrometry of transfluthrin in rat plasma and brain

Hooshfar

Mortuza

Rogers

et al. 2017

Rapid Comm Mass Spectrometry

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Section: Resultsmentioning

confidence: 99%

“…Transfluthrin has relatively low acute toxicity in mammals and is selectively toxic to insects . Nevertheless, it is highly toxic to fish and aquatic organisms and can induce urinary bladder tumors and hepatic adenomas in rats and female mice at high chronic doses . Like other pyrethroids it has potential neurotoxic effects .…”

Section: Introductionmentioning

confidence: 99%

Gas chromatography/negative chemical ionization mass spectrometry of transfluthrin in rat plasma and brain

Hooshfar

Mortuza

Rogers

et al. 2017

Rapid Comm Mass Spectrometry

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“…In order to do this, the major metabolites of the target compound must be identified and then substances that can serve as indexes of the absorption amounts of the parent compound must be selected from the metabolites. However, there have hardly been any reports on human metabolism of these pyrethroids, and knowledge about their urinary metabolites in animals also limited (Kaneko 2010;Matsuo et al 2005;Ujihara et al 2010;Yokohira et al 2011). The absorption, disposition, metabolic reactions, and disappearance of metofluthrin (Matsuo et al 2005) and profluthrin (Ujihara et al 2010) …”

Section: Please Scroll Down For Articlementioning

confidence: 96%

“…Exposed rats had tremors, clonic convulsions, increased liver weight and hepatocellular hypertrophy. Metofluthrin produced hepatocellular tumors in rats (Deguchi et al 2009) while transfluthrin induced urinary bladder tumors and necrosis of the urothelial superficial layer in rats given dosed diet for a long term (Yokohira et al 2011). Transfluthrin was even suggested to have a genotoxic effect on the epithelial cells of human nasal mucosa (Tisch, Faulde, and Maier 2005).…”

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confidence: 97%

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Identification of urinary metabolites in rats administered the fluorine-containing pyrethroids metofluthrin, profluthrin, and transfluthrin

Yoshida

2012

Toxicological & Environmental Chemistry

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The major metabolites in urine of rats administered the fluorine-containing pyrethroids transfluthrin, profluthrin, and metofluthrin, which are used widely recently as mosquito repellents or mothproof repellents, were identified to establish biological indexes for evaluating the absorption amounts of these pyrethroids in the general population. A single dose of 300 mg kg À1 body weight of each pyrethroid was separately administered intraperitoneally to male Sprague-Dawley rats and urine samples were collected until 24 hours after the administration. The metabolites identified by gas chromatography-mass spectrometry were as follows: 2,3,5,6-tetrafluorobenzyl alcohol, 2,3,5,6-tetrafluorobenzoic acid, and 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid (DCCA) for transfluthrin; 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol, 4-methyl-2,3,5,6-tetrafluorobenzoic acid, 4-hydroxymethyl-2,3,5,6-tetrafluorobenzyl alcohol (HOCH 2 -FB-Al), and 2,2-dimethyl-3-(1-propenyl)-cyclopropanecarboxylic acid (MCA) for profluthrin; 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol, HOCH 2 -FB-Al and MCA for metofluthrin. In addition, several compounds estimated to be metabolites were detected as follows: hydroxylated DCCA and its lactone for transfluthrin; 4-hydroxymethyl-2,3,5,6-tetrafluorobenzoic acid (HOCH 2 -FB-Ac), hydroxylated MCA and its lactone for profluthrin; 4-methoxymethyl-2,3,5,6-tetrafluorobenzoic acid, HOCH 2 -FB-Ac, hydroxylated MCA, and its lactone for metofluthrin. The pyrethroids administered underwent metabolic reactions such as ester hydrolysis and oxidation, and most of the metabolites were excreted as their conjugates into urine. These findings should be useful as basic data for evaluating the health effects of exposure to pyrethroids for the general population.

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Allethrin induced toxicity in the male reproductive tract of rats contributes to disruption in the transcription of genes involved in germ cell production

Madhubabu

Yenugu

2013

Environ. Toxicol.

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Pyrethroids are known to be neurotoxic. However, their toxic effects including that of allethrin on the male reproductive tract are not elucidated. Adult male rats were treated orally with 25, 50, 100, and 150 mg/kg body weight allethrin every day for 60 days. Lipid peroxidation was increased (p < 0.001) in the caput, cauda, and testes. Nitric oxide production was increased (p < 0.001) in the caput, but unaltered in the cauda and testes. The activities of catalase, glutathione peroxidase, glutathione-S-transferase, and superoxide dismutase were decreased in the caput and cauda where as a decrease was observed in the testis obtained from allethrin treated rats. In the epididymides and testes, damage to tubular architecture, congestion, degeneration of epithelial cell lining, intestinal edema, and presence of dead or degenerating spermatids were observed in a dose dependent manner. The expression profile of genes involved in spermatogenesis (Tgf-beta1), sperm maturation (Spag11e), and sperm function (Defb22) were reduced (p < 0.001) in allethrin rats. The expression of p53 gene was decreased and increased phosphorylation of MAPK (p42/p44) expression was observed the male reproductive tract tissues of allethrin treated rats. Although earlier studies have reported the effects of allethrin inhalation because of the use of mosquito coils and vaporizers, our results for the first time prove that oral exposure to allethrin could affect fertility and may contribute to deregulation of cell cycle in the male reproductive tract.

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The effects of oral treatment with transfluthrin on the urothelium of rats and its metabolite, tetrafluorobenzoic acid on urothelial cells in vitro

Cited by 15 publications

References 27 publications

Gas chromatography/negative chemical ionization mass spectrometry of transfluthrin in rat plasma and brain

Gas chromatography/negative chemical ionization mass spectrometry of transfluthrin in rat plasma and brain

Identification of urinary metabolites in rats administered the fluorine-containing pyrethroids metofluthrin, profluthrin, and transfluthrin

Allethrin induced toxicity in the male reproductive tract of rats contributes to disruption in the transcription of genes involved in germ cell production

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