The effects of oral administration of (—)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold

Eccles, Ronald; Jawad, M. S. M.; Morris, S.

doi:10.1111/j.2042-7158.1990.tb06625.x

Cited by 87 publications

(52 citation statements)

References 10 publications

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“…In contrast, aromatic vapours (e.g. menthol) produce symptomatic relief of congestion without accompanying change in rhinomanometry measures (Eccles 1990).…”

Section: Discussionmentioning

confidence: 99%

Nasal decongestants for the common cold

Taverner¹,

Bickford²,

Draper³

1999

Cochrane Database of Systematic Reviews

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“…In contrast, aromatic vapours (e.g. menthol) produce symptomatic relief of congestion without accompanying change in rhinomanometry measures (Eccles 1990).…”

Section: Discussionmentioning

confidence: 99%

Nasal decongestants for the common cold

Taverner¹,

Bickford²,

Draper³

1999

Cochrane Database of Systematic Reviews

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“…Inhalation of menthol vapour on sucking a menthol lozenge causes a sensation of improved airflow due to a cool sensation in the nose, without any objective change in nasal airway resistance as illustrated in Figure 5 [78]. Menthol vapour can relieve symptoms of nasal congestion but is not a nasal decongestant.…”

Section: Efficacymentioning

confidence: 95%

“…Menthol is used in vaporubs, lozenges, and nasal sprays to relieve the sensation of nasal stuffiness associated with colds, and this effect is brought about by stimulation of cold receptors in the nose [77,78]. Menthol lozenges are monographed by the FDA as effective cough drops and menthol may influence cough by acting on airway sensory nerves or smooth muscle [79].…”

Section: Pharmacologymentioning

confidence: 99%

Over the counter medicines for colds

Eccles

2009

Commond Cold

Self Cite

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Over the counter (OTC) medicines may be defined as medicines that are freely available to the public without a prescription from a doctor. Self-medication for common cold is now encouraged by most government health authorities in order not to overload health resources in winter. This chapter examines the efficacy of the different groups of medicines for the relief of common cold symptoms (analgesics, decongestants, antihistamines, antitussives, menthol, expectorants and mucolytics, throat lozenges and sprays, multisymptom products, and hot drinks). Safety is the most important factor in any common cold medicine because of the widespread use of the medicines. Because of limitations in dose due to safety concerns many OTC medicines are used at the limits of efficacy and there is often little clinical data to support efficacy, and safety is often supported from a long history of safe use. Aspirin, paracetamol and ibuprofen are the most widely used analgesic treatments to alleviate pain and fever both as monotherapies and in combination with other cold medicines and their efficacy and safety is supported by data from trials on other pain models. The efficacy of nasal decongestants can be supported by clinical trials, and similarly the symptom relief provided by menthol for nasal congestion. The efficacy data for antihistamines, and antitussives is limited and controversial, and there is no real clinical support for the efficacy of expectorants and mucolytics. There is no doubt that all of the OTC common cold medicines are popular with consumers and that they do provide relief from symptoms that in some cases may be more due to a placebo effect than a pharmacological effect of an active ingredient. Multi-symptom medicines provide a safe and convenient way of treating the common cold syndrome of multiple symptoms but their use is sometimes criticised when not all symptoms need to be treated. Hot drinks can provide immediate and sustained relief from symptoms, especially cough and sore throat.

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“…These factors include the thermal receptors in the vestibule and mucosa, and the mucocilliary function. Eccles et al 30 found that the nasal feeling of airflow, but not the resistance, is affected by inhaling menthol. Jones et al 31 reported a slightly increased nasal resistance, not accompanied by a corresponding feeling of obstruction, following aspirin use.…”

Section: Discussionmentioning

confidence: 99%

“…It is worth noting that, although the VAS has been widely used in rhinological research, [20][21][22][23][24][25][26][29][30]33 there are no studies validating this tool for assessing the subjective perception of nasal patency. Sipilä,22 in dividing the scale into quartiles, and Jose and Ell, 34 in using categorical scales, found a good correlation between rhinometric measurements and subjective data.…”

Section: Discussionmentioning

confidence: 99%

A reprodutibilidade do espelho de Glatzel modificado na aferição da permeabilidade nasal

Brescovici

Roithmann

2008

Rev. Bras. Otorrinolaringol.

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The Glatzel Mirror (GM) is used to evaluate nasal patency.Validation studies are not available in the literature. This paper aims to verify the GM test reproducibility and the correlation between the intra-subject condensation area and nasal patency subjective perception. Methods: This is a prospective study. 25 subjects were evaluated with the GM for five consecutive minutes, every half an hour for 4 hours; every day, beginning in the early afternoon, every Thursday for five consecutive weeks. A visual analogue scale was used to evaluate nasal patency perception in all periods. Results: The total correlation coefficient (right + left areas) found between the condensation area and the subjective perception was r = 0.04 (p = 0.37). On the left side it was r = 0.08 (p = 0.09) and on the right side r = 0.05 (p = 0.28). The mean unilateral variation coefficient was less than 15% and the total was less than 12%, regardless of the time period interval between test and re-test. Conclusion: We did not observe any significant correlation between the subjective perception of breathing and the condensation area. Unilateral variability was higher than the total (right + left area) and the test variability was the same between the different time periods of measurements.

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The effects of oral administration of (—)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold

Cited by 87 publications

References 10 publications

Nasal decongestants for the common cold

Nasal decongestants for the common cold

Over the counter medicines for colds

A reprodutibilidade do espelho de Glatzel modificado na aferição da permeabilidade nasal

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