The effects of Opium Addiction on Thyroid and Sex Hormones in Diabetic and Non-Diabetic Male and Female Rats

Asadikaram, Gholamreza; Vakili, Sina; Asiabanha, Majid; Shahrokhi, Nader; Savardashtaki, Amir

doi:10.4183/aeb.2018.466

Cited by 6 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drug-induced hypersecretion caused by dopamine receptor blocking agents, dopamine depleting agents, histamine receptor antagonist, estrogens, anti-androgens, serotonin reuptake inhibitors, and calcium channel blockers 79 83…”

Section: Causes Of Hyperprolactinemiamentioning

confidence: 99%

Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Ghoreshi

Akbari

Sharif-zak

et al. 2022

Journal of Investigative Medicine

View full text Add to dashboard Cite

The prolactin hormone (PRL) is often secreted by lactotrophic cells of the anterior pituitary and has been shown to play a role in various biological processes, including breast feeding and reproduction. The predominant form of this hormone is the 23 kDa form and acts through its receptor (PRLR) on the cell membrane. This receptor is a member of the superfamily of hematopoietic/cytokine receptors. PRL also has a 16 kDa subunit with anti-angiogenic, proapoptotic, and anti-inflammatory effects which is produced by the proteolytic breakdown of this hormone under oxidative stress. Although the common side effects of hyperprolactinemia are exerted on the reproductive system, new studies have shown that hyperprolactinemia has a wide variety of effects, including playing a role in the development of autoimmune diseases and increasing the risk of cardiovascular disease, peripartum cardiomyopathy, and diabetes among others. The range of PRL functions is increasing with the discovery of multiple sites of PRL secretion as well as PRLR expression in various tissues. This review summarizes current knowledge of the biology of PRL and its receptor, as well as the role of PRL in human pathophysiology.

show abstract

Section: Causes Of Hyperprolactinemiamentioning

confidence: 99%

Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Ghoreshi

Akbari

Sharif-zak

et al. 2022

Journal of Investigative Medicine

View full text Add to dashboard Cite

show abstract

“…Recently, the World Health Organization (WHO) reported that among Islamic countries, Iran has the highest rate of opioids abuse [ 19 ]. Animal studies suggest that consumption of narcotics results in thyroid dysfunction [ 20 , 21 ]. Besides, in some trials, diminished T3 uptake has been shown in opium abusers [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017

Pezeshki,

Pourmontaseri,

Homayounfar

et al. 2023

BMC Endocr Disord

View full text Add to dashboard Cite

Background Addiction increases the risk of different lifelong disorders. However, there are limited studies evaluating the effects of opioid use disorder (OUD) on thyroid function. The present study aimed to compare the thyroid function of individuals with and without OUD. Methods This cross-sectional study was conducted on 700 eligible participants of the Persian Cohort of Fasa, Iran. Pregnant women and participants with false or missing data were excluded from the study. Remained participants were divided into case and control groups based on the recorded history of OUD. Frozen plasma samples of the cohort bank were used to determine the levels of T3, T4, and thyroid-stimulating hormone (TSH). The thyroid function was compared between the two groups using the Mann-Whitney test (P < 0.05). Results The mean age of the final studied population (n = 648) was 54.0 ± 9.8 years, including 336 men (49.1%) and 197 participants with OUD (28.8%). The median levels of TSH, T4, and T3 were 2.91 ± 4.61, 9.26 ± 3.65, and 1.22 ± 0.49, respectively. The case group had significantly higher TSH (3.72 ± 6.2 vs. 2.58 ± 3.75, P < 0.001) and lower T4 (8 ± 3.6 vs. 9.8 ± 3.5, P < 0.001). Also, T3 was slightly lower in the case group (1.1 ± 0.5 vs. 1.3 ± 0.5; P = 0.369), although this association was only significant in female opium users (P < 0.001). Conclusions The present findings revealed that OUD caused a reduction in T4 while increasing TSH. Therefore, OUD may lead to the development of primary hypothyroidism, which needs to be investigated in future studies.

show abstract

“…Recently, the World Health Organization (WHO) reported that among Islamic countries, Iran has the highest rate of opium abuse [19]. Studies on rodent models suggest that consumption of narcotics (opium and morphine) results in the dysregulation of THs [20,21]. Besides, in some trials, diminished T3 uptake has been shown in opium abusers [22].…”

Section: Introductionmentioning

confidence: 99%

Thyroid function in opium users: A Cross-Sectional Study on PERSIAN Cohort of Fasa, 2017

Pezeshki

Pourmontaseri

Homayounfar

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Addiction increases the risk of different lifelong disorders. However, there are limited studies evaluating the effects of opium use on thyroid. The present study aimed to compare the thyroid function of opium users and non-users. Methods This cross-sectional study was conducted on 700 participants of the Persian Cohort of Fasa, Iran. Pregnant women and participants with false or missing data were excluded from the study. Frozen plasma samples of the cohort bank were used to determine the levels of T3, T4, and thyroid-stimulating hormone (TSH). The thyroid function was compared between the two groups using Mann-Whitney test (P < 0.05). Results The mean age of the study population (n = 648) was 54.0 ± 9.8 years, including 336 men (49.1%) and 197 opium users (28.8%). The median levels of TSH, T4, and T3 were 2.91 ± 4.61, 9.26 ± 3.65, and 1.22 ± 0.49, respectively. The opium users had significantly higher TSH (3.72 ± 6.2 vs. 2.58 ± 3.75) and lower T4 (8 ± 3.6 vs. 9.8 ± 3.5) levels (P < 0.001). Also, T3 was slightly lower in opium users (1.1 ± 0.5 vs. 1.3 ± 0.5; P = 0.369), although this association was only significant in female opium users (P < 0.001). Conclusions The present findings revealed that opium use causes a reduction in T4, while increasing TSH. Therefore, opium use may lead to the development of primary hypothyroidism, which needs to be investigated in future studies.

show abstract

The effects of Opium Addiction on Thyroid and Sex Hormones in Diabetic and Non-Diabetic Male and Female Rats

Cited by 6 publications

References 32 publications

Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017

Thyroid function in opium users: A Cross-Sectional Study on PERSIAN Cohort of Fasa, 2017

Contact Info

Product

Resources

About