The effects of opioid antagonists on ingestive behavior in the domestic fowl

McCormack, James F.; Denbow, D. Michael

doi:10.1016/0091-3057(87)90472-2

Cited by 30 publications

(9 citation statements)

References 43 publications

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“…One possible explanation for the similarity in naloxone sensitivity is a lack of differential sensitivity at the dose examined. This explanation does not seem to be likely because previous experiments examining dose-response relationships have shown that the food and water intake of RC or SCWL is attenuated by naloxone at doses from 2.5 to 10 mg/kg body weight, with the most effective dose generally being either 5 or 10 mg/kg body weight (McCormack and Denbow, 1987). Naloxone may exhibit differential potency in RC and SCWL stocks at doses either slightly lower or higher than 5 mg/ kg body weight, but this would require a differential response to emerge and wane over a The RC chicks were 35 days of age and had a mean body weight of 1,171 g. The SCWL chicks were 35 days of age by guest on August 13, 2015 http://ps.oxfordjournals.org/ nloaded from dramatically narrow dose range.…”

Section: Discussionmentioning

confidence: 77%

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Ingestive Behavior of Meat and Egg-Type Chickens: Equal Sensitivity to Naloxone

McCormack

Denbow

1987

Poultry Science

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The efficacy of the opioid antagonist naloxone in attenuating ingestive behavior in stocks of chickens genetically selected for either meat (Rock-Cornish, RC) or egg production (Single-Comb White Leghorn, SCWL) was investigated. Because the stocks differ markedly in growth rate, two experiments were conducted to compare RC and SCWL cockerels at similar body weights and at the same age. Birds were injected intramuscularly with either isotonic saline or naloxone HCl at a dose of 5 mg/kg body weight. Food and water were offered ad libitum 15 min postinjection. In RC and SCWL stocks of similar body weight, naloxone significantly attenuated cumulative food and water intake through 210 min following the return of food and water. When administered to RC and SCWL stocks of the same age, naloxone significantly attenuated cumulative food intake for 300 min and cumulative water intake at 60 and 120 min. The relatively long-term depressions in cumulative food and water intake were attributable to significant decreases in incremental consumption within early time periods. There was no significant difference in the efficacy of naloxone in attenuating ingestive behavior when the stocks were compared at either similar body weights or at the same age. The results demonstrate that genetic selection for meat or egg production has not significantly altered opioid mechanisms regulating food and water intake in the domestic fowl.

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Section: Discussionmentioning

confidence: 77%

“…Aves (Cooper and Turkish, 1981;Deviche and Schepers, 1984a,b;McCormack and Denbow, 1987). However, the role of opioids in the manifestation of obesity in Aves has not been evaluated.…”

Section: Opioids Also Influence Ingestive Behavior Inmentioning

confidence: 97%

Ingestive Behavior of Meat and Egg-Type Chickens: Equal Sensitivity to Naloxone

McCormack

Denbow

1987

Poultry Science

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“…This result is consistent with the fact that in rats, naloxone has a biological half life of less than one hour (Tepperman et al 1983). Given to juncos, naloxone attenuated food intake when the birds were not food-deprived, as it is the case in pigeons and chicks (Deviche andSchepers 1984a, McCormack andDenbow 1987a). These observations demonstrate that naloxone disrupts the normal control of feeding when access to food is unlimited.…”

Section: Discussionmentioning

confidence: 70%

“…Specifically, administration of opioid antagonists such as naloxone generally decreases feeding (Cooper and Turkish 1981, Deviche and Schepers 1984a, McCormack and Denbow 1987a, whereas treatment with opioid agonists stimulates this behavior (Deviche and Schepers 1984b, McCormack and Denbow 1988, Savory et al 1989. Evidence that the attenuation of feeding by opioid antagonists results from their binding to opioid receptors is provided by the observation that this attenuation is stereoselective (Deviche and Wohland 1984b).…”

Section: Introductionmentioning

confidence: 95%

“…Studies on domesticated birds demonstrate that food intake is controlled by various neurochemicals including opioids (Chick Gallus domesticus: Denbow and McCormack 1990, McCormack and Denbow 1987a, Japanese Quail Coturnix coturnix japonica: McCormack and Denbow 1987b, Domestic Pigeon Columba livia: Cooper and Turkish 1981, Deviche and Schepers 1984a,b, Deviche and Wohland 1984a,b, Deviche et al 1984. Specifically, administration of opioid antagonists such as naloxone generally decreases feeding (Cooper and Turkish 1981, Deviche and Schepers 1984a, McCormack and Denbow 1987a, whereas treatment with opioid agonists stimulates this behavior (Deviche and Schepers 1984b, McCormack and Denbow 1988, Savory et al 1989.…”

Section: Introductionmentioning

confidence: 97%

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