2010
DOI: 10.2478/s11536-010-0031-8
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The effects of one-year simvastatin therapy on women’s bone mineral density

Abstract: Only few studies have reported that bone fracture risk is decreased in hypercholesterolemic postmenopausal women treated with statin therapy. Because of a lack of longitudinal studies on the effect of statins on bones, the aim of our investigation was to estimate the simvastatin therapy effects on bone mineral density in hypercholesterolemic postmenopausal women. Our investigation was carried out on 53 postmenopausal women with hypercholesterolemia. The women included in the study were divided into two groups.… Show more

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Cited by 2 publications
(4 citation statements)
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“…Several recent studies have shown that pleiotropic effects of statins also include an influence on bone metabolism. There are experimental (Chang et al 2011;Gradosova et al 2011) and clinical (Dimic et al 2011;Gotoh et al 2011) studies where positive effects of statins on bone metabolism were observed. In our model, significant negative effects of fluvastatin (Kubatka et al 2013) or neutral effects of pravastatin alone and in combination with melatonin (this study) on femur compact bone thickness in rats were found.…”
Section: Figurementioning
confidence: 99%
“…Several recent studies have shown that pleiotropic effects of statins also include an influence on bone metabolism. There are experimental (Chang et al 2011;Gradosova et al 2011) and clinical (Dimic et al 2011;Gotoh et al 2011) studies where positive effects of statins on bone metabolism were observed. In our model, significant negative effects of fluvastatin (Kubatka et al 2013) or neutral effects of pravastatin alone and in combination with melatonin (this study) on femur compact bone thickness in rats were found.…”
Section: Figurementioning
confidence: 99%
“…The osteoporosis etiology is complex and multifactorial (Weinstein, 2001; Bonucci & Ballanti, 2014). Osteoporosis can be observed throughout the natural aging process and health factors, such as hormonal disorders, a sedentary lifestyle and immobility, inadequate nutrient intake, metabolic and chronic inflammatory diseases, as well as prolonged use of drugs, can aggravate bone loss and accelerate osteoporosis development (Rosenson et al, 2005; Dimic et al, 2010; Weinstein, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…Bisphosphonates, and more recently statins, have been used in therapeutic protocols to treat bone diseases with different etiologies (Dimic et al, 2010; Rogers et al, 2011; Khosla et al, 2012; Oryan et al, 2015). Due to their efficacy, safety, and remarkable selectivity for bone tissue, bisphosphonates have been prescribed as the standard treatment for osteoporosis (Bellido & Plotkin, 2011; Ruan et al, 2012; Briot & Roux, 2015).…”
Section: Introductionmentioning
confidence: 99%
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