The Effects of One-Anastomosis Gastric Bypass on Fatty Acids in the Serum of Patients with Morbid Obesity

Abstract

Purpose Obesity is associated with alterations in serum fatty acid profiles. One-anastomosis gastric bypass is a type of bariatric surgery used in the treatment of morbid obesity. The aim of this study was to establish if, between 6 and 9 months after this procedure, the fatty acid composition in the serum of patients normalizes to values similar to the healthy, lean population. Materials/Methods The study included 46 patients that underwent surgical treatment for obesity with one-anastomosis gastric bypass. The serum fatty acid composition was determined using gas chromatography-mass spectrometry. Principal component analysis was conducted to detect the differences between fatty acid profiles in patients pre- and post-surgery, and in 29 control nonobese subjects. Results Patients with morbid obesity were characterized by lowered levels of beneficial odd- and branched-chain fatty acids and polyunsaturated fatty acids. While the odd- and branched-chain fatty acid amounts normalized 6–9 months after bariatric treatment, the polyunsaturated fatty acid levels did not. Moreover, the total fatty acid profiles of patients pre- and post-bariatric surgery were still markedly different than those of lean, healthy controls. Conclusion Following one-anastomosis gastric bypass, there are some beneficial changes in serum fatty acids in treated patients, possibly due to weight loss and dietary regimen changes. However, they may be insufficient to restore the proper levels of other fatty acids, which may need to be additionally supplemented. Graphical abstract

Association of branched-chain fatty acids with metabolic syndrome: a systematic review and meta-analysis of observational studies

“…Table 1 depicts the main features of the 9 selected studies in detail. It is noteworthy that all of these studies were carried out in high-income countries (United States, 11,22 Poland, 23–26 Norway, 27 Northern Spain 28 and Netherlands 29 ) between 2015 and 2021. The study designs included 4 cross-sectional studies and 2 longitudinal studies, with 3 studies including both cross-sectional and longitudinal components.…”

Changes in serum oxylipin profile after one anastomosis gastric bypass

“…The pro le of oxylipins were further used in constructing multivariate projection models in order to visualize the in uence of OAGB surgery on their serum concentrations. In contrast to the FA pro les (Pakiet et al, 2021), the quanti ed oxylipins panel allowed for separation of pre-OAGB patients' results from follow-up results. The ability of oxylipins to differentiate between pre and post bariatric patients was similarly reported in sleeve gastrectomy and Roux-En-Y gastric bypass (López, 2021), however different follow-up times between ours and this study prohibits us from de nitely comparing the effects of one bariatric procedure from another.…”

The impact of the interplay of the intestinal microbiome and diet on the metabolomic and health outcomes of bariatric surgery

“…BS causes significant changes in the fatty acid (FA) profile in serum and adipose tissues. [65][66][67][68] Alterations in the FAs composition and metabolism are a well-established feature of obesity. 69 The comparison of FAs profiles by standard statistical analysis revealed significant differences in some FAs between patients with morbid obesity and controls with normal weight, as well as significant FAs changes in patients after OAGB.…”