The effects of okra (Abelmoschus esculentus L.) products on glycemic control and lipid profile: A comprehensive systematic review

Nikpayam, Omid; Safaei, Ehsan; Bahreini, Nazgol; Saghafi-Asl, Maryam

doi:10.1016/j.jff.2021.104795

Cited by 13 publications

(9 citation statements)

References 65 publications

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“…The anti-hyperglycemic effect of okra has been seen in different animal models of T2D, which corroborates our current findings. For example, previous systematic reviews conducted in an adequate number of pre-clinical studies have shown that the extracts of okra or its various fractions have a significant effect on FBG and HbA1c when given as a short or long treatment in animal models of T2D, as demonstrated by its lowering effects ( Nikpayam et al, 2021 ; Sereno et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis of pre-clinical evidence demonstrated improved insulin sensitivity, lipid profile, and body weight without direct analysis of fasting blood glucose (FBG) and glycated haemoglobin (HbA1c) in the animal model of diabetes ( Sereno et al, 2022 ). Interestingly, a comprehensive review by ( Nikpayam et al, 2021 ) has also demonstrated the beneficial effect of okra on lipid profiles and glycemic parameters; however, this study also analysed evidence from animal models of obesity and T2D in addition to T2D patients.…”

Section: Introductionmentioning

confidence: 99%

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Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence

et al. 2023

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Background: Despite the use of available pharmaceutical drugs, high rates of metabolic diseases and cardiovascular disorders are alarming. This calls for alternative therapies that can attenuate these complications. Therefore, we investigated the beneficial effects of okra on glycaemic control in pre-diabetes and type 2 diabetes mellitus (T2D).Methods: MEDLINE and Scopus were searched for relevant studies. Collected data were analysed using RevMan and reported as mean difference and 95% confidence intervals (CI). Eight studies, including 331 patients with pre-diabetes or T2D, were eligible.Results: Our findings showed that okra treatment reduced the levels of fasting blood glucose: mean difference (MD) = −14.63 mg/dL; 95% CI (-25.25, −4.00, p = 0.007); I2 = 33%, p = 0.17 compared to placebo. Glycated haemoglobin, however, did not differ significantly between the groups: MD = 0.01%; 95%CI (-0.51, 0.54, p = 0.96); I2 = 23%, p = 0.28.Conclusion: this systematic review and meta-analysis found that okra treatment improves glycaemic control in patients with pre-diabetes or T2D. The findings suggest that okra may be used as a supplemental dietary nutrient, especially in pre-diabetic and T2D patients due to its potential to regulate hyperglycaemia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence

et al. 2023

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“…Further, an in vivo study demonstrated that supplementation with 2•5 %, 5 % and 10 % okra powder could significantly decrease FBS in rats feeding with high-fat diet (37) . Okra is considered a functional food, as it is a source of mucilage, fibres, bioactive polysaccharides and antioxidant compounds (38) . It seems that the hypoglycaemic effects of this vegetable may be due to the above ingredients.…”

Section: Disscusionmentioning

confidence: 99%

The effect of Abelmoschus esculentus L. (Okra) extract supplementation on glycaemic control, inflammation, kidney function and expression of PPAR-α, PPAR-γ, TGF-β and Nrf-2 genes in patients with diabetic nephropathy: a triple-blind, randomised, placebo-controlled trial

Nikpayam,

Saghafi-Asl,

Safaei

et al. 2023

Br J Nutr

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The present study was carried out to evaluate the effects of okra extract supplementation on kidney function, glycemic control, inflammation, and gene expression in patients with diabetic nephropathy (DN). A total of 64 DN patients based on the inclusion and exclusion criteria were recruited in this triple-blind placebo-controlled randomized clinical trial. Participants were randomly allocated to receive a 125-mg capsule of dried okra extract (DOE) (n=32) or placebo (n=32) for 10 weeks. At the baseline and endpoint of the trial, kidney function, glycemic indices, inflammation, and gene expression were evaluated. Statistical analysis showed that fasting blood glucose (FBG), Hemoglobin A1C (HbA1c) and insulin resistance significantly reduced in the DOE group although between-group analysis did not show any significant difference. Also, no significant difference was observed in urine protein, urine creatinine, and hs-CRP between the two groups. Furthermore, gene expression of PPAR-α, PPAR-γ, TGF-β, and Nrf-2 did not affect the end of the trial in comparison with the baseline. According to the present study, DOE did not have impressive effects on kidney function, inflammation, glycemic management, and gen expression in patients with DN.

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“…Okra (Malvaceae) shows antidiabetic properties that include anti-oxidation, antiinflammatory, and blood glucose and lipid regulation [193,194]. Okra seed extract reduced TNFα-stimulated VCAM-1 and SELE expression and protected HMEC-1 from H 2 O 2 injury, which might be attributed to high concentrations of quercetin 3-O-(malonyl)-glucose, quercetin Cortex-3-O-glucose-xylose and kaempferol-3-O-glucose [195].…”

Section: Other Foodmentioning

confidence: 99%

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food

Tan

Cheong

Cheang

2022

Oxygen

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The rising prevalence of chronic metabolic disorders, such as obesity and type 2 diabetes, most notably associated with cardiovascular diseases, has emerged as a major global health concern. Reactive oxygen species (ROS) play physiological functions by maintaining normal cellular redox signaling. By contrast, a disturbed balance occurring between ROS production and detoxification of reactive intermediates results in excessive oxidative stress. Oxidative stress is a critical mediator of endothelial dysfunction in obesity and diabetes. Under a hyperglycemic condition, the antioxidant enzymes are downregulated, resulting in an increased generation of ROS. Increases in ROS lead to impairment of endothelium-dependent vasodilatations by reducing NO bioavailability. Chronic treatments with antioxidants were reported to prevent the development of endothelial dysfunction in diabetic patients and animals; however, the beneficial effects of antioxidant treatment in combating vascular complications in diabetes remain controversial as antioxidants do not always reverse endothelial dysfunction in clinical settings. In this review, we summarize the latest progress in research focused on the role of ROS in vascular complications of diabetes and the antioxidant properties of bioactive compounds from medicinal plants and food in animal experiments and clinical studies to provide insights for the development of therapeutic strategies.

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The effects of okra (Abelmoschus esculentus L.) products on glycemic control and lipid profile: A comprehensive systematic review

Cited by 13 publications

References 65 publications

Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence

Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence

The effect of Abelmoschus esculentus L. (Okra) extract supplementation on glycaemic control, inflammation, kidney function and expression of PPAR-α, PPAR-γ, TGF-β and Nrf-2 genes in patients with diabetic nephropathy: a triple-blind, randomised, placebo-controlled trial

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food

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