The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study

Panidis, Dimitrios; Τζιόμαλος, Κωνσταντίνος; Koiou, Ekaterini; Kandaraki, Eleni; Tsourdi, Elena; Delkos, Dimitrios; Kalaitzakis, Emmanouil; Katsikis, Ilias

doi:10.1186/1477-7827-8-151

Cited by 20 publications

(27 citation statements)

References 46 publications

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“…For instance, while no alteration has been reported in TC, TAG, HDL-C and LDL-C in some studies (DiamantiKandarakis et al 2008, Cakal et al 2011, Gomes et al 2011), a recent report by Sahin et al (2014) shows significant dyslipidemia in patient with PCOS. Inconsistent findings are also available in the literature showing no alteration (Panidis et al 2010, Sahin et al 2014 or increased concentration of insulin in PCOS (Liu et al 2007, Cakal et al 2011, Gomes et al 2011. In contrast to inconsistent reports on blood lipids and insulin, a common surge has been reported in the serum concentration of LH, testosterone and FAI in all conducted studies (Liu et al 2007, Panidis et al 2010, Gomes et al 2011, Sahin et al 2014, but the alteration has not been shown in the serum concentration of FSH or HOMA-IR (Liu et al 2007, Panidis et al 2010, Sahin et al 2014.…”

Section: Discussionmentioning

confidence: 44%

Matrix metalloproteinases 2 and 9 and MMP9/NGAL complex activity in women with PCOS

et al. 2016

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It is believed that matrix metalloproteinases (MMPs) play important roles in follicular development and pathogenesis of polycystic ovary syndrome (PCOS). However, conflicting results are available about the alteration of MMP2 and MMP9 concentrations or activities in PCOS. In fact, there is no study entirely investigating both concentration and activity of these MMPs and serum levels of their tissue inhibitors TIMP2 and TIMP1, as well as lipocalin-bound form of MMP9 (MMP9/NGAL). Therefore, the thoroughness of previous studies is questionable. This study was conducted to determine circulatory concentration of MMP2, MMP9, MMP9/NGAL complex, TIMP1 and TIMP2 as well as gelatinase activities of MMP2, MMP9 and MMP9/NGAL complex in women with PCOS and controls. Mean age and BMI as well as serum levels of total cholesterol, triacylglycerol, HDL-C, LDL-C, fasting blood sugar (FBS), insulin, estradiol and sex hormone-binding globulin did not differ between groups, whereas a marked decrease in FSH and significant increases in LH, LH/FSH ratio, testosterone and free androgen index were observed. Women with PCOS and controls showed closed concentrations of MMP2, MMP9, MMP9/NGAL, TIMP1 and TIMP2. Gelatinase activity of MMP9 was found significantly higher in PCOS than in controls (64.53G15.32 vs 44.61G18.95 respectively) while patients and healthy subjects showed similar activities of MMP2 and MMP9/NGAL complex. Additionally, PCOS patients showed a higher MMP9/TIMP1 ratio compared with control women. Direct correlations were also observed between circulatory MMP9 level and the concentration and activity of MMP9/NGAL complex. In conclusion, based on the results of present study, we believe that MMP9 may be involved in the pathogenesis of PCOS.Reproduction (2016) 151 305-311

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Section: Discussionmentioning

confidence: 44%

Matrix metalloproteinases 2 and 9 and MMP9/NGAL complex activity in women with PCOS

et al. 2016

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“…On the other hand, several studies showed no significant differences in lipocalin-2 levels between women complicated with PCOS and healthy controls [6,11]. However, Cakal et alreported that serum lipocalin-2 concentrations significantly increased in women with PCOS versus age-and BMI-matched controls.…”

Section: Prace Oryginalnementioning

confidence: 94%

“…Lipocalin-2 binds to bacterial iron-laden siderophores to inhibit bacterial growth [9]. Several studies have been published reporting either increased, decreased, or unchanged lipocalin levels in both PCOS and other insulin resistance-related disorders, but the potential mechanism underlying these inconsistent results has not been wholly elucidated [3,[6][7][8][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Hyperinsulinaemia and decreasing insulin sensitivity usually contribute to metabolic disturbances in PCOS [2]. Insulin induces androgen production in the cells and suppresses the sex hormone binding globulin in liver; thus, the concentrations of more potent forms of plasma-free androgens increase [6]. Moreover, excess adipose tissue due to hyperinsulinaemia may be due to a more potent testosterone from androstenedione based on the enhanced activity of 17 β hydroxy steroid dehydrogenase activity in adipose tissue [6].…”

Section: Introductionmentioning

confidence: 99%

“…It has been proposed that insulin resistance may have a pivotal role in the development of PCOS; nonetheless, the pathophysiology of this disease has not been wholly elucidated [4]. This syndrome is associated with a higher incidence of sub-clinical chronic inflammation, obesity, and related disorders including insulin resistance, metabolic syndrome, diabetes mellitus, hyperlipidaemia, and cardiovascular risk [2,[5][6]. Hyperinsulinaemia and decreasing insulin sensitivity usually contribute to metabolic disturbances in PCOS [2].…”

Section: Introductionmentioning

confidence: 99%

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Związek między stężeniami lipokaliny-2 i testosteronu wolnego w zespole policystycznych jajników

Yılmaz¹,

Temür²,

Çalan

et al. 2017

Endokrynologia Polska

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Introduction: Lipocalin-2 is an adipokine that is mainly produced from adipocytes and macrophages. Data related to PCOS and other obesity-associated disorders have shown divergent results. Here, we studied lipocalin-2 concentrations in women with PCOS and in healthy women, and investigated the potential contributors underlying lipocalin association with PCOS. Material and methods: Forty-four women with PCOS and 47 age-and BMI-matched healthy women were enrolled. Fasting serum glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP), and free testosterone levels were measured. The body fat percentage was measured by bioelectrical impedance. Results: Lipocalin-2 concentrations were significantly higher in the PCOS group than in the control group (55.74 ± 17.54 ng/mL vs. 36.46 ± 19.62 ng/mL, p = 0.011). There was a correlation between lipocalin-2 levels and free testosterone. In a multiple regression model, the body fat percentage, HOMA-IR, and hs-CRP were not associated with lipocalin-2. However, only free testosterone was associated with lipocalin-2. A "lipocalin-2 = 11.214 + (1.943 × free-testosterone)" equation was obtained. Conclusions: Serum lipocalin-2 levels were higher in women with PCOS, and only free testosterone was associated with lipocalin-2. Lipocalin-2 levels and their influencing factors have discrepant results in both PCOS and other obesity-or insulin resistance-related metabolic disorders. Thus, the potential role of lipocalin-2 in PCOS should be clarified. (Endokrynol Pol 2017; 68 (1): 7-12)

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Lipocalin‐2 expression and serum levels as early predictors of type 2 diabetes mellitus in obese women

et al. 2017

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Obesity and diabetes are increasing in epidemic proportions globally. Lipocalin-2 (LCN-2) is an inflammatory adipocytokine and obesity-related marker of low-grade inflammation. We aimed to investigate, for first time, the possible role of LCN-2 expression and serum levels in prediction of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) among obese Egyptian women. This study included 188 obese women and 180 controls. Obese women were subdivided into three subgroups according to their fasting blood glucose, normal glucose tolerance (NGT), IGT and T2DM. Circulating LCN-2 expression levels were determined by real time polymerase chain reaction. Serum LCN-2 concentrations were assessed by ELISA. Our findings revealed that LCN-2 expression and serum levels were higher in obese women compared to lean controls. They were higher in IGT and T2DM obese cases than in NGT obese women. Receiver operating characteristic analyses revealed that LCN-2 expression level was a useful biomarker discriminating IGT from NGT and T2DM from IGT obese women (AUC were 0.735 and 0.740, respectively). It was an independent predictor of IGT and T2DM among obese women. Serum LCN-2 level was a useful biomarker discriminating IGT from NGT and T2DM from IGT obese women (AUC were 0.705 and 0.728, respectively). It was independent predictor of T2DM without predicting IGT among obese women. The power of combined LCN-2 serum levels and expression in discriminating between IGT from NGT and T2DM from IGT obese women was high (AUC 5 0.717 and 0.741, respectively). In conclusion, LCN-2 expression and serum levels could discriminate IGT from NGT and T2DM from IGT obese women and early predicting T2DM among obese women. While, LCN-2 expression level was the independent predictor of IGT in obese women. Combination of both LCN-2 expression and serum levels improved their diagnostic value in early detection of IGT and T2DM among obese women. V C 2017 IUBMB Life, 69(2): [88][89][90][91][92][93][94][95][96][97] 2017

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The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study

Cited by 20 publications

References 46 publications

Matrix metalloproteinases 2 and 9 and MMP9/NGAL complex activity in women with PCOS

Matrix metalloproteinases 2 and 9 and MMP9/NGAL complex activity in women with PCOS

Związek między stężeniami lipokaliny-2 i testosteronu wolnego w zespole policystycznych jajników

Lipocalin‐2 expression and serum levels as early predictors of type 2 diabetes mellitus in obese women

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