The effects of nutrients on symptoms in women with endometriosis: a systematic review

Huijs, Emma; Nap, A.

doi:10.1016/j.rbmo.2020.04.014

Cited by 36 publications

(44 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inositols and ALA derivatives could positively affect insulin sensitivity, reduce androgens, and improve ovulation rhythm enhancing fertility and reducing pelvic pain in endometriosis [49,50]. ALA supplementation has been traditionally used in pregnant women with peripheral neuropathy [51]; used for six weeks postpartum in women after primary Csection with hysterotomy closure improved the healing process and decreased the C-section scar defects [52].…”

Section: Ala In Pcosmentioning

confidence: 99%

Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid

Pop

Crișan²,

Barca

et al. 2021

Processes

View full text Add to dashboard Cite

Alpha-lipoic acid (ALA, thioctic acid), a naturally-occurring essential dithiol compound, has become a common ingredient in many pharmaceutical and food supplement products (FSP), used in oxidative stress-dependent pathologies; oral bioavailability of ALA is limited by pharmacokinetic particularities that reduce its therapeutic efficacy-reduced solubility, lack of gastric stability and hepatic degradation, doubled by formulation hinders. The objectives were to develop a solid oral 600 mg ALA FSP to obtain an optimal pharmaceutical profile compared to a reference listed drug (RLD) with a similarity factor f2 50. A comparative dissolution study was performed; an HPLC method was used for ALA quantification. After planning combinatory simulations (formulation stage), two prototype formulas (#1 and #2) were manufactured and further optimized by adjusting ALA physical characteristics and the excipients quantities (#3 and #4) in order to achieve the Quality Target Product Profile. A misshapen of ALA’s in vitro release was observed for #3 Formula (f2 = 31.6); the optimal profile was obtained for Formula #4 (f2 = 58.5). A simple quantitative formula is not enough to assure good ALA bioavailability; the formulation needs multiple compounding modulations under physicochemical compatibility algorithms, with multiple dissolution profiles testing back-ups. It is essential to ensure a formulation with an in vitro dissolution comparable with the RLD, allowing the compound to reach its target level to assure the optimum claimed antioxidant activity of ALA at the cellular level, even for food supplement formulations.

show abstract

Section: Ala In Pcosmentioning

confidence: 99%

Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid

Pop

Crișan²,

Barca

et al. 2021

Processes

View full text Add to dashboard Cite

show abstract

“…Women with endometriosis frequently report beneficial effects from dietary modification on their pain experience, however, evidence for a correlation between particular foodstuffs and macro-or micronutrients remains of low quality (Huijs and Nap, 2020). The emergence of strong and convincing evidence of a link between diet, the microbiota, and the development of chronic pain symptoms in a number of disorders, including those associated with neuroinflammation, has opened up a new and exciting avenue for investigation (Guo et al, 2019;Martin et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Saunders

Horne

2021

Cell

380

305

View full text Add to dashboard Cite

“…The high-resolution ultrasound (40mHz) allows to follow the evolution of the size of the uterine horn implants in a precise, non-invasive way and to quickly assess the progression of endometriosis. This procedure was performed at PIV (Small Animal Imaging, Cochin Institute, Paris, A recent review [9] described the benefit of additional intake of fatty acids, antioxidants and a combination of vitamins and minerals on endometriosis-associated symptoms. More studies are necessary to gain evidence on food products or nutrients efficacy to alleviate endometriosis syndromes, with an attention to their relative amounts [9].…”

Section: Ultrasonography Monitoringmentioning

confidence: 99%

“…This procedure was performed at PIV (Small Animal Imaging, Cochin Institute, Paris, A recent review [9] described the benefit of additional intake of fatty acids, antioxidants and a combination of vitamins and minerals on endometriosis-associated symptoms. More studies are necessary to gain evidence on food products or nutrients efficacy to alleviate endometriosis syndromes, with an attention to their relative amounts [9]. The animal gut is a complex ecosystem of host cells, microbiota, and available nutrients, and the microbiota prevents several degenerative diseases in humans and animals via immunomodulation.…”

Section: Ultrasonography Monitoringmentioning

confidence: 99%

A new strategy against endometriosis: Oral probiotic treatments

Chouzenoux¹,

Jeljeli²,

Doridot³

et al. 2021

Clin Obstet Gynecol Reprod Med

View full text Add to dashboard Cite

Purpose: Endometriosis is a chronic, estrogen-dependent, benign disease characterized by the presence of endometrial tissue outside the uterus. The benefit of nutritive complements on endometriosis-associated symptoms has been described. The purpose of this study was to evaluate in vivo the effect of probiotics on the development and pain due to endometriosis. Method:We used a mouse model of endometriosis orally treated with one (P1: Saccharomyces Boulardii) or two probiotics (P2: Saccharomyces Boulardii + Lactobacillus Acidophilus), during 4 or 12 weeks. We followed the lesions growth by ultrasonography, the pain suffered by the mice with behavioral and qRT-PCR tests and their immune status by FACS and ELISA techniques.Results: After 4 and 12 weeks of treatments, we observed that volume and size of the lesions were significantly lower. Clinically, heat sensitivity is decreased only by P1-treated at W4 while tactile sensitivity is higher in P2-treated mice. The levels of AOPP in the sera, reflect of the oxidation of proteins, is significantly reduced by all the treatments at W12. The serum levels of zonulin, a marker of the intestinal barrier permeability, and pro-inflammatory cytokines IL-6 and TNF-α were significantly reduced by the P1 and the P2 treatments. Conclusion:Treatment with one or two probiotics, have different but both favorable effects on clinical, immune and physiologic parameters in endometriosis. Because of its better results on pain and a greater ease of handling, Saccharomyces boulardii seems to be more suited to be used as a new therapeutic strategy for endometriosis.

show abstract

The effects of nutrients on symptoms in women with endometriosis: a systematic review

Cited by 36 publications

References 44 publications

Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid

Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid

Endometriosis: Etiology, pathobiology, and therapeutic prospects

A new strategy against endometriosis: Oral probiotic treatments

Contact Info

Product

Resources

About