The Effects of Nonfocused External Ultrasound on Tissue Temperature and Adipocyte Morphology

Garcia, Onelio; Schafer, Mark E.

doi:10.1177/1090820x12469627

Cited by 30 publications

(40 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionsupporting

confidence: 88%

“…7,15 Similar to the present findings, ultrasound treatment was reported to induce the formation of multiple small pores in the adipocytes, allowing dispersion of triglycerides into interstitial space and lymphatic vessels. 7,15 It is conceivable that triglycerides can then be absorbed and metabolized by endogenous lipases to glycerol and free fatty acids and incorporated in the total lipoprotein pool. Of note, serum lipids were unchanged 8,12,15 or slightly elevated, but still within the normal range, 14 in experimental animals and in patients subjected to liporeductive ultrasound treatments, accounting for substantial safety of this procedure from a metabolic viewpoint.…”

Section: Discussionsupporting

confidence: 88%

“…These findings suggest that ultrasound-induced cavitation, at appropriate settings and timing, does not create local adverse conditions that may favor tissue injury and subsequent inflammatory/fibrotic reaction, in keeping with recent observations in swine skin in vivo. 15 On the other hand, the integrity of the vascular components of the adipose tissue can favor the removal of interstitial fat droplets and putative proinflammatory mediators released from adipocytes, conceivably by lymphatic drainage. 16 …”

Section: Discussionmentioning

confidence: 99%

“…8,14 On the other hand, Med 2 Contour (General Project, Montespertoli, Italy) uses a different approach, as it is based on 2 angled nonfocused transducers that create a weakly focused ultrasound field within the subcutaneous fat pad at the point where the beams overlap. 15 …”

mentioning

confidence: 99%

“…It has been shown that adipose cell cavitation can induce focal alterations of the plasma membrane and lipid leakage, 15 but little is known about the possible noxious effects of ultrasound on adipocytes, other cell types of the adipose tissue (blood vessels and mast cells), and the neighboring tissues crossed by the ultrasound beam (epidermis and dermis).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Histological and Ultrastructural Effects of Ultrasound-induced Cavitation on Human Skin Adipose Tissue

Bani

Freschi³

et al. 2013

Plastic and Reconstructive Surgery Global Open

View full text Add to dashboard Cite

Background:In aesthetic medicine, the most promising techniques for noninvasive body sculpturing purposes are based on ultrasound-induced fat cavitation. Liporeductive ultrasound devices afford clinically relevant subcutaneous fat pad reduction without significant adverse reactions. This study aims at evaluating the histological and ultrastructural changes induced by ultrasound cavitation on the different cell components of human skin.Methods:Control and ultrasound-treated ex vivo abdominal full-thickness skin samples and skin biopsies from patients pretreated with or without ultrasound cavitation were studied histologically, morphometrically, and ultrastructurally to evaluate possible changes in adipocyte size and morphology. Adipocyte apoptosis and triglyceride release were also assayed. Clinical evaluation of the effects of 4 weekly ultrasound vs sham treatments was performed by plicometry.Results:Compared with the sham-treated control samples, ultrasound cavitation induced a statistically significant reduction in the size of the adipocytes (P < 0.001), the appearance of micropores and triglyceride leakage and release in the conditioned medium (P < 0.05 at 15 min), or adipose tissue interstitium, without appreciable changes in microvascular, stromal, and epidermal components and in the number of apoptotic adipocytes. Clinically, the ultrasound treatment caused a significant reduction of abdominal fat.Conclusions:This study further strengthens the current notion that noninvasive transcutaneous ultrasound cavitation is a promising and safe technology for localized reduction of fat and provides experimental evidence for its specific mechanism of action on the adipocytes.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Histological and Ultrastructural Effects of Ultrasound-induced Cavitation on Human Skin Adipose Tissue

Bani

Freschi³

et al. 2013

Plastic and Reconstructive Surgery Global Open

View full text Add to dashboard Cite

show abstract

Ultrasound for Aesthetic Applications

Bader

Makin

Abramowicz

2021

J of Ultrasound Medicine

View full text Add to dashboard Cite

show abstract

Comprehensive Evaluation of the BeShape One Device: Assessing Thermal Safety in Noninvasive Body Contouring Using Advanced Techniques

Ramot,

Karakuz,

Willenz

et al. 2024

Lasers Surg Med

View full text Add to dashboard Cite

ObjectivesThis study aims to assess the thermal safety profile of the BeShape One Device, a noninvasive, high‐intensity, non‐focused ultrasound device designed for reducing waist circumference. This device possesses several features that distinguish it from other commercial ultrasound‐based fat reduction devices. The study focuses on evaluating temperature‐related physiological changes through thermal safety analysis and histopathology in a swine model.Materials and MethodsThe study utilized three types of applicators—active, demo, and modified—to comprehensively assess the device's impact on various skin layers. Five female Large White X Landrace swine were involved in the study, and the BeShape One Device was applied to designated treatment sites using a specific treatment protocol. The assessment included clinical observations, skin reaction evaluations, gross pathology, histopathological analyses, and advanced temperature measurement techniques, including needle thermocouples, thermal cameras, COMSOL modeling, and CEM43 analysis.ResultsClinical observations indicated the animals’ overall well‐being throughout the study. Skin reactions, including erythema, edema, bruising, and crust formation, were temporary and resolved over time. Gross pathology revealed no treatment‐related pathologies, except for a discoloration related to a tattoo procedure. Histopathological analyses at 30 and 90 days posttreatment demonstrated an absence of heat‐related lesions in skin layers. Needle thermocouples and thermal camera measurements supported the device's ability to maintain consistent thermal homogeneity. COMSOL modeling and CEM43 analysis predicted no thermal damage to the skin, confirming the safety of the BeShape One Device.ConclusionsUnder the experimental conditions, the BeShape One Device demonstrated a favorable safety profile. Clinically and histopathologically, no adverse effects were observed. The device's ability to achieve thermal homogeneity in skin layers was validated through advanced temperature measurement techniques. COMSOL modeling and CEM43 analysis further supported the conclusion that the device is safe, making it a promising option for noninvasive body contouring procedures.

show abstract

The Effects of Nonfocused External Ultrasound on Tissue Temperature and Adipocyte Morphology

Cited by 30 publications

References 18 publications

Histological and Ultrastructural Effects of Ultrasound-induced Cavitation on Human Skin Adipose Tissue

Histological and Ultrastructural Effects of Ultrasound-induced Cavitation on Human Skin Adipose Tissue

Ultrasound for Aesthetic Applications

Comprehensive Evaluation of the BeShape One Device: Assessing Thermal Safety in Noninvasive Body Contouring Using Advanced Techniques

Contact Info

Product

Resources

About