The effects of non‐invasive mechanic ventilator modes on intraocular pressure in COPD patients with hypercapnic respiratory failure

Abstract

Background Chronic obstructive pulmonary disease (COPD) is not fully reversible disease that is characterized by progressive restricting airflow. Non‐invasive mechanical ventilation (NIMV) treatment can be used in COPD patients who had type 2 respiratory failure. This study aimed to determine the effect of BPAP S/T and AVAPS modes on intraocular pressure (IOP), central corneal thickness (CCT) in 40 type 2 respiratory failure patients with COPD. Methods Forty patients with type 2 respiratory failure who were hospitalized between June and December 2018 with the diagnosis of COPD exacerbations were included to the study. Patients followed up without NIMV for 12 hours after the end of exacerbations treatments end. After IOP, visual acuity and CCT were measured in all patients at the same time (11.00 am), same NIMV treatment was applied to the patients for 4 hours (AVAPS‐BPAP S/T). Then the measurements were repeated. The effects of these NIMV modes on IOP were evaluated. Results After NIMV treatment, it was observed that the mean IOP increased statistically significantly (13.3 vs 12.3 mm Hg; P = 0.001). After treatment with NIMV, there was a decrease for CCT close to statistical significance (P = 0.057) Conclusion As a result; increased IOP and thinning of CCT after NIMV treatment has been shown. The type of NIMV and the level of inspiratory pressure needed in hypercapnic respiratory failure seem to affect IOP and it should be cautiously used to increase IOP.

Intraocular pressure of adults in a coastal province in southern China: the Fujian cross-sectional eye study

“…Another novel point was that IOP was associated with chronic disease history after taking into account the interdependency of the parameters. There were several reports on relationship between IOP and chronic diseases, however, these reports mostly focused on a single disease (30)(31)(32)(33), and there were no relevant reports on population-based data. Our study was a population based cross sectional survey, and it can objectively reflect the correlation between IOP and chronic diseases, provide practical data support for basic research, and attract the attention of policy-making.…”