The effects of nitroglycerin during cardiopulmonary resuscitation

Stefaniotou, A.; Varvarousi, Giolanda; Varvarousis, Dimitrios; Xanthos, T.

doi:10.1016/j.ejphar.2014.04.002

Cited by 3 publications

(2 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, no large-scale clinical studies demonstrating the efficacy of nitroglycerin, isosorbide dinitrate, and nicardipine in cardiac arrest patients have been reported. However, some case reports were published reporting resuscitation being achieved by the administration of nitroglycerin in refractory cardiac arrest (Ward and Reid, 1984; Osada et al, 2000; Stefaniotou et al, 2014). Moreover, it was reported that acute coronary syndrome (ACS), which occurs after resuscitation from cardiac arrest, and cardiac arrest caused by ACS were improved by the administration of isosorbide dinitrate (Heming et al, 2010; Manzo-Silberman et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database

et al. 2019

View full text Add to dashboard Cite

The survival rate of cardiac arrest patients is less than 10%; therefore, development of a therapeutic strategy that improves their prognosis is necessary. Herein, we searched data collected from medical facilities throughout Japan for drugs that improve the survival rate of cardiac arrest patients. Candidate drugs, which could improve the prognosis of cardiac arrest patients, were extracted using “TargetMine,” a drug discovery tool. We investigated whether the candidate drugs were among the drugs administered within 1 month after cardiac arrest in data of cardiac arrest cases obtained from the Japan Medical Data Center. Logistic regression analysis was performed, with the explanatory variables being the presence or absence of the administration of those candidate drugs that were administered to ≥10 patients and the objective variable being the “survival discharge.” Adjusted odds ratios for survival discharge were calculated using propensity scores for drugs that significantly improved the proportion of survival discharge; the influence of covariates, such as patient background, medical history, and treatment factors, was excluded by the inverse probability-of-treatment weighted method. Using the search strategy, we extracted 165 drugs with vasodilator activity as candidate drugs. Drugs not approved in Japan, oral medicines, and external medicines were excluded. Then, we investigated whether the candidate drugs were administered to the 2,227 cardiac arrest patients included in this study. The results of the logistic regression analysis showed that three (isosorbide dinitrate, nitroglycerin, and nicardipine) of seven drugs that were administered to ≥10 patients showed significant association with improvement in the proportion of survival discharge. Further analyses using propensity scores revealed that the adjusted odds ratios for survival discharge for patients administered isosorbide dinitrate, nitroglycerin, and nicardipine were 3.35, 5.44, and 4.58, respectively. Thus, it can be suggested that isosorbide dinitrate, nitroglycerin, and nicardipine could be novel therapeutic agents for improving the prognosis of cardiac arrest patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Nitroglycerin has a favorable hemodynamic profile which promotes forward blood flow and has been associated with increased rates of resuscitation and improved postresuscitation outcome [19]. It can diffuse through all membranes, including the blood-brain barrier, and it is a potent cerebrovasodilator that increases cerebral blood flow through the release of nitric oxide (NO) from the endothelium [20].…”

Section: Improving Microcirculatory Blood Flowmentioning

confidence: 99%

Personalized physiology-guided resuscitation in highly monitored patients with cardiac arrest—the PERSEUS resuscitation protocol

2019

Self Cite

View full text Add to dashboard Cite

Resuscitation guidelines remain uniform across all cardiac arrest patients, focusing on the delivery of chest compressions to a standardized rate and depth and algorithmic vasopressor dosing. However, individualizing resuscitation to the appropriate hemodynamic and ventilatory goals rather than a standard Bone-size-fits-all^treatment seems a promising new therapeutic strategy. In this article, we present a new physiology-guided treatment strategy to titrate the resuscitation efforts to patient's physiologic response after cardiac arrest. This approach can be applied during resuscitation attempts in highly monitored patients, such as those in the operating room or the intensive care unit, and could serve as a method for improving tissue perfusion and oxygenation while decreasing post-resuscitation adverse effects.

show abstract

Nitric oxide in the cardio-cerebrovascular system: Source, regulation and application

Fu,

Lu,

Gao

et al. 2024

Nitric Oxide

View full text Add to dashboard Cite

The effects of nitroglycerin during cardiopulmonary resuscitation

Cited by 3 publications

References 90 publications

Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database

Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database

Personalized physiology-guided resuscitation in highly monitored patients with cardiac arrest—the PERSEUS resuscitation protocol

Nitric oxide in the cardio-cerebrovascular system: Source, regulation and application

Contact Info

Product

Resources

About