The Effects of Newly Developed Linen Dressings on Decubitus Ulcers

Skórkowska-Telichowska, Katarzyna; Kulma, Anna; Żuk, Magdalena; Czuj, Tadeusz; Szopa, Jan

doi:10.1089/jpm.2011.0404

Cited by 6 publications

(5 citation statements)

References 9 publications

(7 reference statements)

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“…After 2.5 years of treatment, which did not bring the desired effect, we conducted a 12-weeks, four-step treatment with linen bandages. Also in this case there was a significant reduction in the size and depth of the wound, exudate and fibrin level, and pain experienced by the patient [ 298 ].…”

Section: The Effect Of Phenolic Compounds On Healing Of Incised Anmentioning

confidence: 99%

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

Działo

Mierziak

Korzun

et al. 2016

IJMS

Self Cite

498

327

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Phenolic compounds constitute a group of secondary metabolites which have important functions in plants. Besides the beneficial effects on the plant host, phenolic metabolites (polyphenols) exhibit a series of biological properties that influence the human in a health-promoting manner. Evidence suggests that people can benefit from plant phenolics obtained either by the diet or through skin application, because they can alleviate symptoms and inhibit the development of various skin disorders. Due to their natural origin and low toxicity, phenolic compounds are a promising tool in eliminating the causes and effects of skin aging, skin diseases, and skin damage, including wounds and burns. Polyphenols also act protectively and help prevent or attenuate the progression of certain skin disorders, both embarrassing minor problems (e.g., wrinkles, acne) or serious, potentially life-threatening diseases such as cancer. This paper reviews the latest reports on the potential therapy of skin disorders through treatment with phenolic compounds, considering mostly a single specific compound or a combination of compounds in a plant extract.

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Section: The Effect Of Phenolic Compounds On Healing Of Incised Anmentioning

confidence: 99%

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

Działo

Mierziak

Korzun

et al. 2016

IJMS

Self Cite

498

327

View full text Add to dashboard Cite

show abstract

“…Indisputably, the regenerative properties of the phenolic compounds are among their strengths and justify the role of this phytochemical group in the therapy of wounds, incised or chronic, burns, infected wounds, etc. (for which, of course, the antimicrobial properties also contribute) [123][124][125][126]. Skin regeneration is a complex process that involves a vascular response (hemostasis and coagulation), cellular response (inflammation), proliferation phase (re-epithelialization), neovascularization (angiogenesis), granulation tissue formation, and remodeling (strengthening by conversion of collagen type III to type I) [127].…”

Section: Effects On Skin Renewal Proliferation Collagen and Elastin Synthesismentioning

confidence: 99%

“…Such activity is also highly desirable in the fight against age-related changes of the skin [131] (wrinkles appearance, loss of elasticity, thinning). Examples of phenolic compounds or herbal preparations that have been demonstrated to exert these mechanisms in vitro and/or in vivo are luteolin [132], epigallocatechin gallate and extracts rich in it, and other tannins [133,134], crude grape pomace and its main constituent gallic acid [135], lignans in seedcake extract [126], other phenolic-rich content extracts from the cacao pod [136], Phyllanthus emblica, Manilkara zapota [137], Clausena excavate [138], Sphaeranthus amaranthoides [139], Meum athamanticum, Centella asiatica, Aegopodium podagraria [140] and many more. Despite the undeniable role of the antioxidant properties of phenolics for skin regeneration, other supplementary mechanisms are found to be involved in the healing/protective processes.…”

Section: Effects On Skin Renewal Proliferation Collagen and Elastin Synthesismentioning

confidence: 99%

Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies

et al. 2021

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Phenolic compounds are a large, heterogeneous group of secondary metabolites found in various plants and herbal substances. From the perspective of dermatology, the most important benefits for human health are their pharmacological effects on oxidation processes, inflammation, vascular pathology, immune response, precancerous and oncological lesions or formations, and microbial growth. Because the nature of phenolic compounds is designed to fit the phytochemical needs of plants and not the biopharmaceutical requirements for a specific route of delivery (dermal or other), their utilization in cutaneous formulations sets challenges to drug development. These are encountered often due to insufficient water solubility, high molecular weight and low permeation and/or high reactivity (inherent for the set of representatives) and subsequent chemical/photochemical instability and ionizability. The inclusion of phenolic phytochemicals in lipid-based nanocarriers (such as nanoemulsions, liposomes and solid lipid nanoparticles) is so far recognized as a strategic physico-chemical approach to improve their in situ stability and introduction to the skin barriers, with a view to enhance bioavailability and therapeutic potency. This current review is focused on recent advances and achievements in this area.

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“…Taking into consideration the complexity of the wound healing process, it is necessary to search for new materials able to imitate various tissues in terms of their function. The most commonly used natural polymers are polysaccharides: starch, cellulose, chitin, alginate and proteins/polypeptides such as wool, gelatin, silk, linen and collagen [7,8,9,10,11,12]. The biopolymers presented below meet the biocompatibility requirements [13,14] and they can influence different biological systems in various ways, for example, tissue processes connected to wound healing, endothelium in contact with endovascular devices, target cells in the genes therapy and stem cells in bioreactors [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Influence of Porous Dressings Based on Butyric-Acetic Chitin Co-Polymer on Biological Processes In Vitro and In Vivo

et al. 2019

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In spite of intensively conducted research allowing for the development of more and more advanced wound dressing materials, there is still a need for dressings that stimulate not only reparative and regenerative processes, but also have a positive effect on infected and/or difficult-to-heal wounds. Porous dressing materials based on butyric-acetic chitin co-polyester containing 90% of butyryl and 10% of acetyl groups (BAC 90/10) can also be included in the group mentioned above. Two types of dressings were obtained by the salt leaching method, i.e. a porous sponge Medisorb R and Medisorb Ag with an antibacterial additive. The aim of the study was to evaluate biological effects of porous Medisorb R and Medisorb Ag dressings under in vitro and in vivo conditions. In an in vitro biodegradation test, no mass loss of Medisorb R dressing was observed within 14 days of incubation in physiological fluids at 37 °C. However, on the basis of the FTIR (Fourier Transform Infrared Spectroscopy) tests, surface degradation of Medisorb R dressing was observed. Additionally, the antibacterial activity of the porous Medisorb Ag dressing containing microsilver as an antibacterial additive was confirmed. The in vivo studies included inflammatory activity, skin irritation and sensitisation tests, as well an assessment of local effect after contact with subcutaneous tissue up to 6 months and skin wounds up to 21 days. In the in vivo tests, the dressings exhibited neither effects of skin irritation nor sensitisation. Under macroscopic examination, in full thickness defects of subcutaneous tissue and skin, the dressings caused wound healing with no inflammation, undergoing the most gradual biodegradation between weeks 4 and 8, and the observed differences were statistically significant. In the histological assessment, a weakened, limited inflammatory process associated with degradation of the material has been observed. The process of skin wound healing under Medisorb R dressing in the early period was accelerated compared to that observed in the control group with a gauze dressing.

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The Effects of Newly Developed Linen Dressings on Decubitus Ulcers

Cited by 6 publications

References 9 publications

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies

Influence of Porous Dressings Based on Butyric-Acetic Chitin Co-Polymer on Biological Processes In Vitro and In Vivo

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