The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol

Czlonkowska, A; Krząścik, Paweł; Sienkiewicz-Jarosz, Halina; Siemiątkowski, Marek; Szyndler, Janusz; Bidziński, Andrzej; Płaźnik, Adam

doi:10.1016/s0091-3057(00)00369-5

Cited by 55 publications

(30 citation statements)

References 19 publications

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“…For instance, ALLO infusion into the nucleus accumbens (NAc) was observed to fully substitute for the discriminative stimulus effects of systemically administered ethanol in rats [19]. Additional studies demonstrated that ALLO administered via the intracerebroventricular (ICV) route accentuated the hypnotic effect of ethanol in mice [7] and dose-dependently increased DA levels within the NAc in rats [32]. Collectively, these findings point to a centrally-mediated involvement of ALLO in ethanol discrimination and hypnosis.…”

Section: Introductionmentioning

confidence: 94%

Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice

Ford

Mark

Nickel

et al. 2007

Behavioural Brain Research

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Although systemic allopregnanolone (ALLO; a positive modulator of GABA A receptors) has been shown to enhance ethanol-reinforced responding and to modulate drinking patterns in rodents, the effects of centrally administered ALLO on ethanol intake are not known. The current work examined the effects of intracranial ALLO on operant ethanol self-administration in food-and water-satiated mice, with a procedure designed to estimate ALLO's influence on appetitive versus consummatory processes. Male C57BL/6J (B6) mice were trained to press an ethanol-appropriate lever by being reinforced with 30-min of continuous access to a 10% ethanol solution. Following surgical implantation of a guide cannula aimed at the lateral ventricle and subsequent habituation to vehicle infusions, ALLO (50-400 ng; ICV) was delivered immediately prior to session start. ALLO doses of 100 and 400 ng were further evaluated for their effects on locomotor behavior within activity chambers. ALLO selectively modulated ethanol intake patterns associated with the onset and maintenance of self-administration, while leaving appetitive (i.e., ethanol seeking) measures unaltered. The effects of ALLO on drinking patterns were dissociable from changes in locomotor behavior, as evidenced by the absence of ALLO's influence on response frequency and horizontal distance traveled. These findings support the premise that manipulations in brain ALLO levels may influence the regulatory processes governing ethanol consumption.

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Section: Introductionmentioning

confidence: 94%

Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice

Ford

Mark

Nickel

et al. 2007

Behavioural Brain Research

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“…There is increasing evidence that sex hormones might have a role in seizure susceptibility (62,63); however, the exact mechanisms are unknown. It has been well documented that sex hormones exert their regulatory effects on neuronal excitability by modulating neurotransmitter receptors including GABA, N-methyl-D-aspartic acid (NMDA), and opioid receptors, as well as by direct and/or indirect regulation of adenosine receptors (64)(65)(66)(67). These mechanisms may be involved in the lower susceptibility of OVX rats to PTZ-induced seizures in the present study.…”

Section: Discussionmentioning

confidence: 59%

Effects of melatonin and theanine administration on pentylenetetrazole-inducedseizures and brain tissue oxidative damage in ovariectomized rats

Choopankareh¹,

Vafaee²,

Shafei³

et al. 2015

Turk J Med Sci

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Background/aim: The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. Materials and methods:The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVX-PTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Mel/Thea-PTZ. Groups 1-4 received saline, while groups 5 and 6 received a combination of Mel/Thea for 6 weeks. All animals except for those in groups 1 and 2 received a single injection of PTZ. Results:The OVX-PTZ group had higher generalized tonic-clonic seizure (GTCS) latency compared to the sham-PTZ group. Administration of Mel/Thea increased minimal clonic seizure and GTCS latencies in both the sham-Mel/Thea-PTZ and OVX-Mel/Thea-PTZ groups compared to the controls. Additionally, PTZ exposure increased malondialdehyde levels and reduced thiol concentrations in brain tissues of both the sham-PTZ and OVX-PTZ groups. Mel/Thea pretreatment resulted in MDA reduction and thiol increase in brain tissues. Conclusion:The results of this study demonstrated the antioxidant and anticonvulsant activities of Mel/Thea despite the presence or absence of ovarian hormones.

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“…Bath application of GABA or GABA A receptor agonist muscimol could induce an early hyperpolarization mediated by Cl -and a late depolarization mediated by the efflux of bicarbonate. These GABA A receptor-mediated responses were blocked by Cl -channel blocker picrotoxin and GABA A receptor blocker bicuculline (Xie et al, 2006), picrotoxin and bicuculline could also induce seizure or convulsion (Cz³onkowska et al, 2000;Yamada et al, 2001). Recent investigation revealed that picrotoxin and bicuculline significantly antagonized the melatonin-induced increase in total sleep time, slow-wave sleep and paradoxical sleep, and the decrease in time to sleep onset and wakefulness (Wang et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Honokiol Potentiates Pentobarbital-Induced Sleeping Behaviors through GABA_AReceptor Cl^-Channel Activation

Ma¹,

Ma²,

Jo³

et al. 2008

Biomolecules and Therapeutics

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− This study was undertaken to investigate whether honokiol could enhance the pentobarbitalinduced sleeping behaviors through γ-aminobutyric acid (GABA) receptor Cl -channel activation. Thirty minutes after the oral administration of honokiol, mice were received sodium pentobarbital (42 mg/kg, i.p.). The time elapsed from pentobarbital injection to the loss of the righting reflex was taken as sleeping latency. The time elapsed between the loss and voluntary recovery of the righting reflex was considered as the total sleeping time. Western blot technique and Cl -sensitive fluorescence probe were used to detect the expression of GABA A receptor subunits and Cl -influx in the primary cultured cerebellar granule cells. Honokiol (0.1 and 0.2 mg/kg) prolonged the sleeping time induced by pentobarbital (42 mg/kg) in a dosage-dependent manner. Honokiol (20 and 50 µM) increased Cl -influx in primary cultured cerebellar granule cells, and selectively increased the GABA A receptor α-subunit expression, but had no effect on the abundance of β or γ-subunits. Chronic treatment with 20 µM honokiol in primary cultured cerebellar neurons did not affect the abundance of GAD65/67. The results suggested that honokiol could potentiate pentobarbital-induced sleeping through GABA A receptor Cl -channel activation.

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The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol

Cited by 55 publications

References 19 publications

Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice

Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice

Effects of melatonin and theanine administration on pentylenetetrazole-inducedseizures and brain tissue oxidative damage in ovariectomized rats

Honokiol Potentiates Pentobarbital-Induced Sleeping Behaviors through GABA_AReceptor Cl^-Channel Activation

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The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol

Cited by 55 publications

References 19 publications

Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice

Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice

Effects of melatonin and theanine administration on pentylenetetrazole-inducedseizures and brain tissue oxidative damage in ovariectomized rats

Honokiol Potentiates Pentobarbital-Induced Sleeping Behaviors through GABAAReceptor Cl-Channel Activation

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Product

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Honokiol Potentiates Pentobarbital-Induced Sleeping Behaviors through GABA_AReceptor Cl^-Channel Activation