The Effects of Nesiritide on Renal Function and Diuretic Responsiveness in Acutely Decompensated Heart Failure Patients With Renal Dysfunction

Owan, Theophilus; Chen, Horng H.; Frantz, Robert P.; Karon, Barry L.; Miller, Wayne L.; Rodeheffer, Richard J.; Hodge, David O.; Burnett, John C.; Redfield, Margaret M.

doi:10.1016/j.cardfail.2007.12.002

Cited by 37 publications

(33 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a preliminary study conduced in patients with HF and mild RI, Nesiritide did not improve renal function but rather showed a worsening respect to the baseline values at admission [37]. However, in a second recent report, Owan et al [38] did not reveal any renal function impairment in terms of creatinine levels and blood urea nitrogen in patients with acute HF. Now the ASCEND-HF is on going to better elucidate the hemodynamic efficacy and renal safety effect by its use [39].…”

mentioning

confidence: 87%

Cardio-renal syndrome: an entity cardiologists and nephrologists should be dealing with collegially

Palazzuoli

Ronco

2011

Heart Fail Rev

View full text Add to dashboard Cite

Heart failure may lead to acute kidney injury and vice versa. Chronic kidney disease may affect the clinical outcome in terms of cardiovascular morbidity and mortality while chronic heart failure may cause CKD. All these disorders contribute to the composite definition of cardio-renal syndromes. Renal impairment in HF patients has been increasingly recognized as an independent risk factor for morbidity and mortality; however, the most important clinical trials in HF tend to exclude patients with significant renal dysfunction. The mechanisms whereby renal insufficiency worsens the outcome in HF are not known, and several pathways could contribute to the "vicious heart/kidney circle." Traditionally, renal impairment has been attributed to the renal hypoperfusion due to reduced cardiac output and decreased systemic pressure. The hypovolemia leads to sympathetic activity, increased renin-angiotensin-aldosterone pathways and arginine-vasopressin release. All these mechanisms cause fluid and sodium retention, peripheral vasoconstriction and an increased congestion as well as cardiac workload. Therapy addressed to improve renal dysfunction, reduce neurohormonal activation and ameliorate renal blood flow could lead to a reduction in mortality and hospitalization in patients with cardio-renal syndrome.

show abstract

mentioning

confidence: 87%

Cardio-renal syndrome: an entity cardiologists and nephrologists should be dealing with collegially

Palazzuoli

Ronco

2011

Heart Fail Rev

View full text Add to dashboard Cite

show abstract

“…Meanwhile the in-hospital death seemed to bear a little relation to the implementation of rhBNP. Several studies also indicated that rhBNP had fewer adverse effects and was safe in renal dysfunctional patients (13,17).…”

Section: Discussionmentioning

confidence: 99%

Continuous administration of recombinant human B-type natriuretic peptide can improve heart and renal function in patients after cardiopulmonary bypass surgery

Xiao

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

Background: Any cardiac surgery under cardiopulmonary bypass (CPB) will induce ischemia-reperfusion injury and systematic inflammatory response, which may lead to exacerbation. Conventional therapy strategy is to use inotropes, diuretics and vasodilator drugs, yet, the therapeutic effects of which need to be improved. Recombinant human B-type natriuretic peptide (rhBNP) has been shown to be efficacious in the treatment of acute decompensated heart failure and acute myocardial infarction. However, the effects of rhBNP on patients carried out CPB surgery is unknown. Methods: We retrospect 357 patients carried out CPB surgery between Jan 1st 2014 and Dec 31st 2015 of our department. And according the use of rhBNP, these patients were divided into two groups: rhBNP group and control group. Patients in rhBNP group were received continuous intravenous rhBNP (0.0075-0.01 μg/kg/min) in 6 hours after CPB surgery, for a period of 72 h. Hemodynamic parameters were measured immediately after CPB surgery, and then at 2, 4, 8, 12 and 24 h after surgery. Blood samples were obtained immediately after surgery and thereafter once a day at 6:00 AM within the first 3 days after surgery. The daily urine volume as well as the time of tracheal intubation, ICU stay and chest drainage were also recorded.

show abstract

“…Patients in this study were admitted for treatment of volume overload but did not require intravenous vasodilator or inotropic therapy for the rapid relief of dyspnea. When used as an adjuvant therapy, the recommended dose of nesiritide induced a lesser increase in serum creatinine (p=0.048) and blood urea nitrogen (p=0.02) compared to the group that did not receive nesiritide [16]. In the Vasodilation in the Management of Acute Congestive heart failure (VMAC) trial, in patients with moderate or severe renal insufficiency and acutely decompensated congestive heart failure, nesiritide did not worsen renal function.…”

Section: Impact Of Nesiritide On Renal Functionmentioning

confidence: 98%

Impact of Nesiritide on Renal Function and Mortality in Patients Suffering from Heart Failure

Dontas

Xanthos

Dontas

et al. 2009

Cardiovasc Drugs Ther

View full text Add to dashboard Cite

show abstract

The Effects of Nesiritide on Renal Function and Diuretic Responsiveness in Acutely Decompensated Heart Failure Patients With Renal Dysfunction

Cited by 37 publications

References 35 publications

Cardio-renal syndrome: an entity cardiologists and nephrologists should be dealing with collegially

Cardio-renal syndrome: an entity cardiologists and nephrologists should be dealing with collegially

Continuous administration of recombinant human B-type natriuretic peptide can improve heart and renal function in patients after cardiopulmonary bypass surgery

Impact of Nesiritide on Renal Function and Mortality in Patients Suffering from Heart Failure

Contact Info

Product

Resources

About