The effects of neonatal paternal deprivation on pair bonding, NAcc dopamine receptor mRNA expression and serum corticosterone in mandarin voles

Yu, Peng; An, Shu-Cheng; Tai, Fadao; Zhang, Xia; He, Fengqin; Wang, Jianli; An, Xiaolei; Wu, Ruiyong

doi:10.1016/j.yhbeh.2012.02.028

Cited by 61 publications

(46 citation statements)

References 69 publications

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“…Exposure of mandarin voles to paternal loss as neonates also lowered their sociality, particularly in females. As adults, the subjects were less parental, less likely to investigate novel conspecifics, and the females were less likely to show partner preference (Jia et al, 2011;Yu et al, 2012;Cao et al, 2014). In California mice, removal of the father 3 days postpartum had no effect on the anxiety of the adult offspring tested in an empty open-field arena, but the subjects showed reduced social interactions and increased aggression (Bambico et al, 2015).…”

Section: Discussionmentioning

confidence: 98%

“…As voles are social animals that sometimes live in groups and are raised by both parents (McGuire and Getz, 1995), we predicted that social disruptions would increase the anxiety levels of adult offspring more than ecological disruptions. Based on previous research in prairie and mandarin voles showing that females are more sensitive than males to manipulations of their social environment such as paternal deprivation and social isolation (Ruscio et al, 2009;Yu et al, 2012), we also predicted that our female subjects would be more susceptible to the impact of postpartum disruptions than males. Given the adverse effects of social isolation in voles (Scotti et al, 2015), we expected the early-life disruptions to have a greater negative effect on the stress reactivity and neuronal development of voles that were isolated as subadults than the socially-housed voles that remained with their same-sex sibling.…”

Section: Introductionmentioning

confidence: 99%

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Socio-Ecological Disruptions at Critical Periods During Development Alter Stress Responses and Hippocampal Dendritic Morphology of Prairie Voles: Implications for Social Monogamy

et al. 2018

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Emotions are often associated with the evolution of monogamy. For example, fear of cuckoldry has been recently proposed as the driving force for human monogamy. We used prairie voles (Microtus ochrogaster) as a model of human behavior to study how stress reactivity is shaped by socio-ecological disruptions experienced as neonates and as subadults. We hypothesized that social disruptions would have a greater impact on the vole's stress levels than ecological disruptions, and that females would be more susceptible to the experience than males. At 6 days postpartum, the housing conditions were manipulated to have offspring raised by: (1) both parents under a protective cover (NoDisrupt); (2) Both parents uncovered (EcoDisrupt); (3) Mother alone covered (SocDisrupt); (4) Mother alone uncovered (SocEcoDisrupt). To experience disruptions as subadults, offspring were weaned then housed either alone (Isolate) or with a same-sex sibling (Social). As adults, each offspring was placed in an open-field arena and tested over 3 consecutive days to measure its behavior in response to an empty space (Day1), a same-sex vole in a container (Day2), and an empty container (Day3). The brain of a subgroup of subjects was processed for Golgi staining to assess the impact of disruptions on hippocampal dendritic morphology in adulthood. Males that experienced social disruption in early life displayed lower stress levels on Day2 of testing than males and females in other groups. This effect was only evident in males that did not experience social disruptions as subadults. Socio-ecological disruptions at postpartum had an unanticipated impact on the hippocampus of the voles. The apical dendrites of the CA3 neurons in male and female voles that experienced either social or ecological disruptions in early life and remained socially isolated as subadults were longer than those in undisturbed voles. Our results suggest that social disruptions experienced in early life modulate the male's stress-related behaviors and may thus influence his monogamous tendencies. Exposure to disruptions may also impact the memory circuits of the brain that monogamous animals use to make mating decisions.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Socio-Ecological Disruptions at Critical Periods During Development Alter Stress Responses and Hippocampal Dendritic Morphology of Prairie Voles: Implications for Social Monogamy

et al. 2018

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“…Father absence has been extensively studied in both human and animal models, and paternal deprivation has been a commonly used manipulation to study the effects of male parenting in animal models (11)(12)(13). Female prairie voles that were raised without a father displayed less alloparenting (care of offspring not their own, usually siblings) (14); took longer to form a pair-bond (14,15); and exhibited less parenting towards their own offspring (15).…”

Section: Introductionmentioning

confidence: 99%

“…Female prairie voles that were raised without a father displayed less alloparenting (care of offspring not their own, usually siblings) (14); took longer to form a pair-bond (14,15); and exhibited less parenting towards their own offspring (15). Father absence in mandarin voles has been shown to affect a host of behavioral and neuroendocrine variables in ways that build on the prairie vole findings, including negative effects on pair-bonding (16), social recognition (17), and play behavior (18). Long-term neuroendocrine effects on offspring include changes in oxytocin and vasopressin systems (14,17,18), estrogen receptors (17), stress systems (19-21), and dopaminergic metabolism (16,22).…”

Section: Introductionmentioning

confidence: 99%

“…Father absence in mandarin voles has been shown to affect a host of behavioral and neuroendocrine variables in ways that build on the prairie vole findings, including negative effects on pair-bonding (16), social recognition (17), and play behavior (18). Long-term neuroendocrine effects on offspring include changes in oxytocin and vasopressin systems (14,17,18), estrogen receptors (17), stress systems (19-21), and dopaminergic metabolism (16,22).…”

Section: Introductionmentioning

confidence: 99%

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Fatherhood alters gene expression within the MPOA

Seelke

Bond

Simmons

et al. 2018

Preprint

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Abstract:Female parenting is obligate in mammals, but fathering behavior among mammals is rare.Only 3-5% of mammalian species exhibit biparental care, including humans, and mechanisms of fathering behavior remain sparsely studied. However, in species where it does exist, paternal care is often crucial to the survivorship of offspring. The present study is the first to identify new gene targets involved in the regulation of fathering behavior in a biparental species using RNA sequencing. In order to determine the pattern of gene expression within the medial preoptic area that is specifically associated with fathering behavior, we identified differentially expressed genes in male prairie voles (Microtus ochrogaster) that experienced one of three social conditions: virgin males, pair bonded males, and males with fathering experience. Differentially expressed genes from each comparison (i.e., Virgin vs Paired, Virgin vs Fathers, and Paired vs Fathers) were evaluated using the Gene Ontology enrichment analysis, and Kegg pathways analysis to reveal metabolic pathways associated with specific differentially expressed genes. Using these tools, we identified a group of genes that are differentially expressed in voles with different amounts of social experience. These genes are involved in a variety of processes, with particular enrichment in genes associated with immune function, metabolism, synaptic plasticity, and the remodeling of dendritic spines. The identification of these genes and processes will lead to novel insights into the biological basis of fathering behavior.

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What Does Animal (Nonhuman) Research Tell Us About Social Deprivation and Social Isolation?

Zeytinoglu

2021

The Handbook of Solitude

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The effects of neonatal paternal deprivation on pair bonding, NAcc dopamine receptor mRNA expression and serum corticosterone in mandarin voles

Cited by 61 publications

References 69 publications

Socio-Ecological Disruptions at Critical Periods During Development Alter Stress Responses and Hippocampal Dendritic Morphology of Prairie Voles: Implications for Social Monogamy

Socio-Ecological Disruptions at Critical Periods During Development Alter Stress Responses and Hippocampal Dendritic Morphology of Prairie Voles: Implications for Social Monogamy

Fatherhood alters gene expression within the MPOA

What Does Animal (Nonhuman) Research Tell Us About Social Deprivation and Social Isolation?

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