The effects of neonatal handling on the development of the adrenocortical response to stress: Implications for neuropathology and cognitive deficits in later life

Meaney, Michael J.; Mitchell, John B.; Aitken, David H.; Bhatnagar, Seema; Bodnoff, Shari R.; Iny, Linda J.; Sarrieau, Alain

doi:10.1016/0306-4530(91)90072-2

Cited by 351 publications

(182 citation statements)

References 82 publications

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“…For instance, handling of rats during the first week of life (Levine and Mullins, 1966) results in a permanent increase of GR capacity (Meaney and Aitken, '1985;Meaney et al, 1988Meaney et al, , 1989Meaney et al, , 1991, less hippocampal damage in the aged animal and improved cognitive functions Issa et al, 1990). Long-lasting changes in corticosterone binding have been observed in the offspring of pregnant rats that were either stressed (Szuran et al, 1992) or adrenalectomized (Angelucci et al, 1983).…”

Section: Ontogenymentioning

confidence: 99%

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Joëls

Kloet

1994

Progress in Neurobiology

367

168

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Section: Ontogenymentioning

confidence: 99%

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Joëls

Kloet

1994

Progress in Neurobiology

367

168

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“…With regard to ontogenetic development, it has been shown that individuals that are hand‐reared or handled by experimenters at an early age exhibit lower levels of glucocorticoids as adults during stressful events than parent‐raised ones (Meaney et al. 1985, 1991; Hemetsberger et al. 2010).…”

Section: Introductionmentioning

confidence: 99%

Behavioural and Hormonal Stress Responses to Social Separation in Ravens, Corvus corax

et al. 2016

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Social life is profitable, but it facilitates conflicts over resources and creates interdependence between individuals. Separating highly social animals triggers intense reactions aimed at re‐establishing lost connections. Less is known, however, about behavioural and physiological responses to separation in socially facultative species, where individuals temporarily form groups and may subsequently leave them. Non‐breeding common ravens (Corvus corax) gather in large numbers at feeding and roosting sites, but otherwise spend time seemingly solitary or in small subgroups. We here studied how ravens cope with being socially isolated, and investigated the life characteristics that might explain potential individual differences. For this, we individually separated captive subadult ravens (n = 25) and housed them in physical and visual isolation from their group members across 4 d. During the separation period, we collected behavioural data and measured the amount of immunoreactive corticosterone metabolites from bird droppings to assess the ravens’ physiological stress response. We found behavioural indicators of stress at the start of the separation, when ravens showed higher levels of tension than of comfort – a pattern that reversed at the end of the separation. Furthermore, we found that the upbringing of ravens affected their behaviour during separation. Hand‐raised birds produced more vocalisations in the beginning of the separation, and were less active at the end, while the reverse pattern occurred with parent‐raised ravens. Contrary to our predictions, we did not find differences in hormonal responses between the beginning and end of the separation period or any link between hormonal responses and behaviours. Ravens’ behavioural responses to social separation stress seem to be dependent on their arousal states, although possible links with hormonal reactions remain unclear. Our results show that behavioural reactions are not always linked with hormonal responses to stress, and further emphasise the importance of investigating effects of early‐life experiences.

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“…This is reflected in behavioral, endocrine, physiological, immunological, and neuro-histochemical changes (reviewed in FernandezTeruel et al, 2002;Meaney, Mitchell, Aitken, & Bhatnagar, 1991;Pryce & Feldon, 2003). EH usually involves 15 min separation from the mother, but anxiolytic effects have also been observed after as little as 3 min handling (e.g., Denenberg & Smith, 1963;Denenberg & Whimbey, 1963;von Hoersten, Dimitrijevic, Markovic, & Jankovic, 1993).…”

Section: Introductionmentioning

confidence: 99%

Marked for life? Effects of early cage‐cleaning frequency, delivery batch, and identification tail‐marking on rat anxiety profiles

Burn

Deacon

Mason

2008

Developmental Psychobiology

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Daily handling of preweanling rats reduces their adult anxiety. Even routine cage-cleaning, involving handling, reduces adult anxiety compared with controls. Cage-cleaning regimes differ between animal breeders, potentially affecting rodent anxiety and experimental results. Here, 92 adult male rats given different cage-cleaning rates as pups, were compared on plus-maze, hyponeophagia, corticosterone, and handling tests. They were pair-housed and half were tailmarked for identification. Anxiety/stress profiles were unaffected by cage-cleaning frequency, suggesting that commercial-typical differences in husbandry contribute little variance to adult rat behavior. However, delivery batch affected some elevated plus-maze measures. Also, tail-marked rats spent three times longer on the plusmaze open arms than their unmarked cagemates, suggesting reduced anxiety, yet paradoxically they showed greater chromodacryorrhoea responses to handling, implying increased aversion to human contact. A follow-up study showed that rats avoided the odor released from the marker pen used. Thus, apparently trivial aspects of procedure can greatly affect experimental results.

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The effects of neonatal handling on the development of the adrenocortical response to stress: Implications for neuropathology and cognitive deficits in later life

Cited by 351 publications

References 82 publications

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Behavioural and Hormonal Stress Responses to Social Separation in Ravens, Corvus corax

Marked for life? Effects of early cage‐cleaning frequency, delivery batch, and identification tail‐marking on rat anxiety profiles

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